PDB: 8BUM — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 2 66.7% 8BUMB
DFGin BLAminus 1 33.3% 8BUME
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUME Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Active DFGin 7.1739 15.4836 BLAminus -146.26, -169.41 35.67, 76.14 -91.08, 23.16 287.18, 101.24 -64.43, -27.28 in-in in 8.3789 Saltbr-in 3.3933 HRD-in -65.58, -57.98 78.09, 6.9 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.86, -32.86 APE9-dihe-na -90.18, 155.36 APE8-dihe-in -60.4, 149.13 APE8-rot-in 310.02 APE67-dihe-in -62.09, -34.98 -57.41, -41.5 APE12-dist-in 12.684 APE11-dist-in 12.1018 APE10-dist-in 6.7473 APE9-dist-in 3.3803 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMB Q9NYV4 715 1040 1490.0 T6X:1101 Type1 Inactive DFGin 6.8637 15.6654 None -134.73, -83.5 -67.29, 93.27 -90.11, 26.53 284.48, 75.06 -65.26, -28.59 in-in in 7.994 Saltbr-in 3.4847 HRD-in -65.89, -56.24 77.66, 6.87 in-in-in SNCiii in-in ActLoopNT-in 3.1268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, -38.62 APE9-dihe-na -95.11, 154.79 APE8-dihe-in -60.97, 148.11 APE8-rot-in 309.8 APE67-dihe-in -61.69, -36.7 -58.55, -38.83 APE12-dist-in 13.4563 APE11-dist-in 11.5984 APE10-dist-in 6.6698 APE9-dist-in 3.6672 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMH Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Inactive DFGin 7.0235 15.4568 None -135.37, -57.05 -84.79, 89.46 -91.01, 22.09 287.95, 72.46 -66.77, -30.21 in-out in 8.0681 Saltbr-out 4.1308 HRD-in -66.21, -56.87 75.95, 5.67 out-in-in SNCoii in-in ActLoopNT-in 2.9548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.45, -40.59 APE9-dihe-na -95.46, 155.5 APE8-dihe-in -61.11, 150.0 APE8-rot-in 312.75 APE67-dihe-in -61.06, -36.71 -56.48, -41.62 APE12-dist-in 13.6249 APE11-dist-in 11.7363 APE10-dist-in 7.1678 APE9-dist-in 3.5793 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUM — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 2 66.7% 8BUMB
DFGin BLAminus 1 33.3% 8BUME
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUME Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Active DFGin 7.1739 15.4836 BLAminus -146.26, -169.41 35.67, 76.14 -91.08, 23.16 287.18, 101.24 -64.43, -27.28 in-in in 8.3789 Saltbr-in 3.3933 HRD-in -65.58, -57.98 78.09, 6.9 in-in-in SNCiii in-in ActLoopNT-in 3.007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.86, -32.86 APE9-dihe-na -90.18, 155.36 APE8-dihe-in -60.4, 149.13 APE8-rot-in 310.02 APE67-dihe-in -62.09, -34.98 -57.41, -41.5 APE12-dist-in 12.684 APE11-dist-in 12.1018 APE10-dist-in 6.7473 APE9-dist-in 3.3803 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMB Q9NYV4 715 1040 1490.0 T6X:1101 Type1 Inactive DFGin 6.8637 15.6654 None -134.73, -83.5 -67.29, 93.27 -90.11, 26.53 284.48, 75.06 -65.26, -28.59 in-in in 7.994 Saltbr-in 3.4847 HRD-in -65.89, -56.24 77.66, 6.87 in-in-in SNCiii in-in ActLoopNT-in 3.1268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.13, -38.62 APE9-dihe-na -95.11, 154.79 APE8-dihe-in -60.97, 148.11 APE8-rot-in 309.8 APE67-dihe-in -61.69, -36.7 -58.55, -38.83 APE12-dist-in 13.4563 APE11-dist-in 11.5984 APE10-dist-in 6.6698 APE9-dist-in 3.6672 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 B 344.0 326.0 0 29 29 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUMH Q9NYV4 715 1039 1490.0 T6X:1101 Type1 Inactive DFGin 7.0235 15.4568 None -135.37, -57.05 -84.79, 89.46 -91.01, 22.09 287.95, 72.46 -66.77, -30.21 in-out in 8.0681 Saltbr-out 4.1308 HRD-in -66.21, -56.87 75.95, 5.67 out-in-in SNCoii in-in ActLoopNT-in 2.9548 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.45, -40.59 APE9-dihe-na -95.46, 155.5 APE8-dihe-in -61.11, 150.0 APE8-rot-in 312.75 APE67-dihe-in -61.06, -36.71 -56.48, -41.62 APE12-dist-in 13.6249 APE11-dist-in 11.7363 APE10-dist-in 7.1678 APE9-dist-in 3.5793 K965R TPO893 TPO893 XRAY 3.36 0.18 0.212 H 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bum Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUM — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name