PDB: 8BUI — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BUIB
DFGin BLAminus 1 33.3% 8BUIE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUIB Q9NYV4 715 1041 1490.0 RV6:1101 Type1 Inactive DFGin 6.8484 15.3849 ABAminus -131.36, -62.29 -89.48, 101.04 -94.93, 20.15 285.65, 74.39 -62.98, -21.99 in-in in 8.0628 Saltbr-in 3.2441 HRD-out -78.21, 99.43 -82.66, -35.16 in-in-in SNCiii in-in ActLoopNT-in 3.1675 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -19.18 APE9-dihe-na -128.33, 156.07 APE8-dihe-in -65.63, 140.55 APE8-rot-in 297.93 APE67-dihe-in -59.87, -34.95 -53.39, -43.04 APE12-dist-in 13.3654 APE11-dist-in 10.9607 APE10-dist-in 7.2526 APE9-dist-in 4.181 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bui CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUIH Q9NYV4 715 1038 1490.0 RV6:1101 Type1 Inactive DFGin 6.9697 15.2814 ABAminus -131.92, -50.63 -89.53, 95.29 -98.99, 14.99 287.64, 76.53 -67.14, -30.95 in-in in 8.1508 Saltbr-in 3.2771 HRD-out -79.19, 77.36 -62.47, -39.48 in-in-in SNCiii in-in ActLoopNT-in 2.9931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.57, -18.14 APE9-dihe-na -112.45, 157.67 APE8-dihe-in -65.3, 140.25 APE8-rot-in 297.23 APE67-dihe-in -58.21, -35.12 -53.14, -43.81 APE12-dist-in 13.665 APE11-dist-in 11.5249 APE10-dist-in 7.0045 APE9-dist-in 3.8741 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bui CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUIE Q9NYV4 715 1039 1490.0 RV6:1101 Type1 Inactive DFGin 7.5392 15.5582 BLAminus -143.87, -178.18 39.61, 79.76 -92.26, 22.29 284.74, 80.02 -58.61, -17.16 in-out in 8.1098 Saltbr-out 3.7147 HRD-out -75.62, 149.49 -131.37, 158.61 out-in-out SNCoio in-out ActLoopNT-in 3.1665 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.18, -17.3 APE9-dihe-na -88.48, 155.1 APE8-dihe-in -64.43, 139.92 APE8-rot-out 15.61 APE67-dihe-in -61.18, -34.77 -50.17, -41.15 APE12-dist-in 13.0189 APE11-dist-in 12.9143 APE10-dist-in 7.0194 APE9-dist-out 6.0272 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bui CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUI — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 66.7% 8BUIB
DFGin BLAminus 1 33.3% 8BUIE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUIB Q9NYV4 715 1041 1490.0 RV6:1101 Type1 Inactive DFGin 6.8484 15.3849 ABAminus -131.36, -62.29 -89.48, 101.04 -94.93, 20.15 285.65, 74.39 -62.98, -21.99 in-in in 8.0628 Saltbr-in 3.2441 HRD-out -78.21, 99.43 -82.66, -35.16 in-in-in SNCiii in-in ActLoopNT-in 3.1675 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -19.18 APE9-dihe-na -128.33, 156.07 APE8-dihe-in -65.63, 140.55 APE8-rot-in 297.93 APE67-dihe-in -59.87, -34.95 -53.39, -43.04 APE12-dist-in 13.3654 APE11-dist-in 10.9607 APE10-dist-in 7.2526 APE9-dist-in 4.181 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bui Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUIH Q9NYV4 715 1038 1490.0 RV6:1101 Type1 Inactive DFGin 6.9697 15.2814 ABAminus -131.92, -50.63 -89.53, 95.29 -98.99, 14.99 287.64, 76.53 -67.14, -30.95 in-in in 8.1508 Saltbr-in 3.2771 HRD-out -79.19, 77.36 -62.47, -39.48 in-in-in SNCiii in-in ActLoopNT-in 2.9931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.57, -18.14 APE9-dihe-na -112.45, 157.67 APE8-dihe-in -65.3, 140.25 APE8-rot-in 297.23 APE67-dihe-in -58.21, -35.12 -53.14, -43.81 APE12-dist-in 13.665 APE11-dist-in 11.5249 APE10-dist-in 7.0045 APE9-dist-in 3.8741 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 H 344.0 324.0 0 29 29 0 [[727, 1020]] 1.0 8bui Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUIE Q9NYV4 715 1039 1490.0 RV6:1101 Type1 Inactive DFGin 7.5392 15.5582 BLAminus -143.87, -178.18 39.61, 79.76 -92.26, 22.29 284.74, 80.02 -58.61, -17.16 in-out in 8.1098 Saltbr-out 3.7147 HRD-out -75.62, 149.49 -131.37, 158.61 out-in-out SNCoio in-out ActLoopNT-in 3.1665 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiio APE10-dihe-na -99.18, -17.3 APE9-dihe-na -88.48, 155.1 APE8-dihe-in -64.43, 139.92 APE8-rot-out 15.61 APE67-dihe-in -61.18, -34.77 -50.17, -41.15 APE12-dist-in 13.0189 APE11-dist-in 12.9143 APE10-dist-in 7.0194 APE9-dist-out 6.0272 K965R TPO893 TPO893 XRAY 3.5 0.184 0.221 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bui Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BUI — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name