PDB: 8BU7 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 8BU7B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU7B Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 7.0774 15.5436 BLAminus -153.2, -179.33 57.0, 56.86 -76.66, 35.76 288.9, 72.8 -62.53, -36.58 in-in in 7.9444 Saltbr-in 2.9696 HRD-in -65.11, -49.8 70.58, 2.94 in-in-in SNCiii in-in ActLoopNT-in 2.9018 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -42.09 APE9-dihe-na -92.76, 146.08 APE8-dihe-in -61.7, 141.25 APE8-rot-in 286.85 APE67-dihe-in -64.16, -31.94 -48.15, -39.73 APE12-dist-in 12.7959 APE11-dist-in 11.3036 APE10-dist-in 6.4396 APE9-dist-in 3.7225 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU7H Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 6.9253 15.2163 BLAminus -150.49, -178.12 60.69, 55.85 -80.72, 28.91 286.49, 71.19 -68.37, -37.18 in-in in 7.9973 Saltbr-in 3.1269 HRD-in -67.99, -49.39 67.61, 1.86 in-in-in SNCiii in-in ActLoopNT-in 2.9304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.1, -50.99 APE9-dihe-na -89.61, 147.06 APE8-dihe-in -59.45, 144.95 APE8-rot-in 311.35 APE67-dihe-in -64.87, -31.1 -48.4, -40.63 APE12-dist-in 13.8207 APE11-dist-in 11.6376 APE10-dist-in 7.151 APE9-dist-in 3.5678 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU7E Q9NYV4 715 1043 1490.0 RS5:1101 Type1 Inactive DFGin 6.9129 15.3311 BLAminus -151.87, 179.81 58.39, 58.15 -75.44, 35.18 288.34, 71.23 -65.18, -38.03 in-in in 7.7566 Saltbr-in 2.771 HRD-in -65.82, -48.21 71.8, 2.22 in-in-out SNCiio in-out ActLoopNT-in 2.8804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.27, -35.49 APE9-dihe-na -79.69, 146.79 APE8-dihe-in -61.33, 142.24 APE8-rot-out 178.46 APE67-dihe-in -63.9, -29.29 -50.85, -42.32 APE12-dist-in 12.5269 APE11-dist-in 12.3359 APE10-dist-in 6.449 APE9-dist-in 3.4892 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU7 — CMGC CDK12_HUMAN

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 8BU7B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BU7B Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 7.0774 15.5436 BLAminus -153.2, -179.33 57.0, 56.86 -76.66, 35.76 288.9, 72.8 -62.53, -36.58 in-in in 7.9444 Saltbr-in 2.9696 HRD-in -65.11, -49.8 70.58, 2.94 in-in-in SNCiii in-in ActLoopNT-in 2.9018 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -42.09 APE9-dihe-na -92.76, 146.08 APE8-dihe-in -61.7, 141.25 APE8-rot-in 286.85 APE67-dihe-in -64.16, -31.94 -48.15, -39.73 APE12-dist-in 12.7959 APE11-dist-in 11.3036 APE10-dist-in 6.4396 APE9-dist-in 3.7225 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU7H Q9NYV4 715 1043 1490.0 No_ligand No_ligand Active DFGin 6.9253 15.2163 BLAminus -150.49, -178.12 60.69, 55.85 -80.72, 28.91 286.49, 71.19 -68.37, -37.18 in-in in 7.9973 Saltbr-in 3.1269 HRD-in -67.99, -49.39 67.61, 1.86 in-in-in SNCiii in-in ActLoopNT-in 2.9304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.1, -50.99 APE9-dihe-na -89.61, 147.06 APE8-dihe-in -59.45, 144.95 APE8-rot-in 311.35 APE67-dihe-in -64.87, -31.1 -48.4, -40.63 APE12-dist-in 13.8207 APE11-dist-in 11.6376 APE10-dist-in 7.151 APE9-dist-in 3.5678 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU7E Q9NYV4 715 1043 1490.0 RS5:1101 Type1 Inactive DFGin 6.9129 15.3311 BLAminus -151.87, 179.81 58.39, 58.15 -75.44, 35.18 288.34, 71.23 -65.18, -38.03 in-in in 7.7566 Saltbr-in 2.771 HRD-in -65.82, -48.21 71.8, 2.22 in-in-out SNCiio in-out ActLoopNT-in 2.8804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -76.27, -35.49 APE9-dihe-na -79.69, 146.79 APE8-dihe-in -61.33, 142.24 APE8-rot-out 178.46 APE67-dihe-in -63.9, -29.29 -50.85, -42.32 APE12-dist-in 12.5269 APE11-dist-in 12.3359 APE10-dist-in 6.449 APE9-dist-in 3.4892 K965R TPO893 TPO893 XRAY 3.245 0.193 0.219 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bu7 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 8BU7 — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name