| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | JAK2-1 | JAK2_HUMAN | 7F7WA | O60674 | 536 | 810 | 1132.0 | 36H:1000 | Type1 | Pseudo | DFGin | 6.915 | 13.7962 | None | -91.54, 171.73 | -67.57, 155.24 | -69.34, -22.33 | 351.29, 21.05 | 78.83, -168.1 | out-na | out | 10.1693 | Saltbr-na | 999.0 | HRD-in | -84.02, -62.23 | 90.48, 0.05 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 9.7232 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -68.04, -35.76 | APE9-dihe-out | -66.77, -25.16 | APE8-dihe-out | -85.21, 3.67 | APE8-rot-na | 284.34 | APE67-dihe-out | -100.56, 25.85 | -66.38, 135.35 | APE12-dist-na | 9.6893 | APE11-dist-na | 11.4731 | APE10-dist-na | 16.0322 | APE9-dist-out | 12.6531 | None | None | None | XRAY | 1.83 | 0.208 | 0.238 | A | 275.0 | 275.0 | 0 | 24 | 24 | 0 | [[545, 807], [849, 1125]] | 2.0 | 7f7w | TYR_JAK2-1_HUMAN | TYR | 5.3e-64 | 222.0 | 2.0 | 260.0 | 259.0 | 698 | 699 | 700 | 702 | 704 | 581 | 597 | 601 | 670 | 672 | 671 | 673.0 | 735 | 722 | 717 | 716 | 715 | 714 | 713 | 712 | 711 | 627 | Tyrosine-protein kinase JAK2 |
| TYR | JAK2-1 | JAK2_HUMAN | 7F7WB | O60674 | 536 | 810 | 1132.0 | 36H:1000 | Type1 | Pseudo | DFGin | 6.9033 | 13.6869 | None | -84.95, 175.07 | -74.42, 156.63 | -70.62, -23.21 | 351.87, 21.25 | 77.0, -167.15 | out-na | out | 10.2517 | Saltbr-na | 999.0 | HRD-in | -79.03, -66.0 | 95.6, -1.12 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 9.4951 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -68.33, -37.68 | APE9-dihe-out | -69.53, -21.97 | APE8-dihe-out | -87.12, 4.19 | APE8-rot-na | 285.11 | APE67-dihe-out | -99.09, 24.95 | -67.63, 136.04 | APE12-dist-na | 9.7044 | APE11-dist-na | 11.4907 | APE10-dist-na | 16.0173 | APE9-dist-out | 12.671 | None | None | None | XRAY | 1.83 | 0.208 | 0.238 | B | 275.0 | 275.0 | 0 | 24 | 24 | 0 | [[545, 807], [849, 1125]] | 2.0 | 7f7w | TYR_JAK2-1_HUMAN | TYR | 5.3e-64 | 222.0 | 2.0 | 260.0 | 259.0 | 698 | 699 | 700 | 702 | 704 | 581 | 597 | 601 | 670 | 672 | 671 | 673.0 | 735 | 722 | 717 | 716 | 715 | 714 | 713 | 712 | 711 | 627 | Tyrosine-protein kinase JAK2 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | JAK2-1 | JAK2_HUMAN | 7F7WA | O60674 | 536 | 810 | 1132.0 | 36H:1000 | Type1 | Pseudo | DFGin | 6.915 | 13.7962 | None | -91.54, 171.73 | -67.57, 155.24 | -69.34, -22.33 | 351.29, 21.05 | 78.83, -168.1 | out-na | out | 10.1693 | Saltbr-na | 999.0 | HRD-in | -84.02, -62.23 | 90.48, 0.05 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 9.7232 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -68.04, -35.76 | APE9-dihe-out | -66.77, -25.16 | APE8-dihe-out | -85.21, 3.67 | APE8-rot-na | 284.34 | APE67-dihe-out | -100.56, 25.85 | -66.38, 135.35 | APE12-dist-na | 9.6893 | APE11-dist-na | 11.4731 | APE10-dist-na | 16.0322 | APE9-dist-out | 12.6531 | None | None | None | XRAY | 1.83 | 0.208 | 0.238 | A | 275.0 | 275.0 | 0 | 24 | 24 | 0 | [[545, 807], [849, 1125]] | 2.0 | 7f7w | Homo sapiens | TYR_JAK2-1_HUMAN | TYR | 5.3e-64 | 222.0 | 2.0 | 260.0 | 259.0 | 698 | 699 | 700 | 702 | 704 | 581 | 597 | 601 | 670 | 672 | 671 | 673.0 | 735 | 722 | 717 | 716 | 715 | 714 | 713 | 712 | 711 | 627 | Tyrosine-protein kinase JAK2 |
| TYR | JAK2-1 | JAK2_HUMAN | 7F7WB | O60674 | 536 | 810 | 1132.0 | 36H:1000 | Type1 | Pseudo | DFGin | 6.9033 | 13.6869 | None | -84.95, 175.07 | -74.42, 156.63 | -70.62, -23.21 | 351.87, 21.25 | 77.0, -167.15 | out-na | out | 10.2517 | Saltbr-na | 999.0 | HRD-in | -79.03, -66.0 | 95.6, -1.12 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 9.4951 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -68.33, -37.68 | APE9-dihe-out | -69.53, -21.97 | APE8-dihe-out | -87.12, 4.19 | APE8-rot-na | 285.11 | APE67-dihe-out | -99.09, 24.95 | -67.63, 136.04 | APE12-dist-na | 9.7044 | APE11-dist-na | 11.4907 | APE10-dist-na | 16.0173 | APE9-dist-out | 12.671 | None | None | None | XRAY | 1.83 | 0.208 | 0.238 | B | 275.0 | 275.0 | 0 | 24 | 24 | 0 | [[545, 807], [849, 1125]] | 2.0 | 7f7w | Homo sapiens | TYR_JAK2-1_HUMAN | TYR | 5.3e-64 | 222.0 | 2.0 | 260.0 | 259.0 | 698 | 699 | 700 | 702 | 704 | 581 | 597 | 601 | 670 | 672 | 671 | 673.0 | 735 | 722 | 717 | 716 | 715 | 714 | 713 | 712 | 711 | 627 | Tyrosine-protein kinase JAK2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|