PDB: 6VQL — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6VQLA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 6VQLA Q9NWZ3 162 458 460.0 R7S:501 Type1 Inactive DFGin 6.9484 14.1016 BLAminus -128.89, 178.86 62.54, 89.32 -112.77, 19.41 307.7, 95.35 -67.01, -28.48 in-out in 8.8675 Saltbr-out 5.76 HRD-in -60.86, -51.23 73.74, 13.24 out-in-in SNCoii in-in ActLoopNT-in 2.8492 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.6, 156.29 APE9-dihe-na 133.29, -167.61 APE8-dihe-in -110.06, 117.8 APE8-rot-in 304.32 APE67-dihe-in -57.05, -22.07 -48.75, -46.61 APE12-dist-in 10.1761 APE11-dist-in 11.8072 APE10-dist-in 6.649 APE9-dist-in 4.2808 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 A 305.0 289.0 8 30 24 6 [[183, 456]] 1.0 6vql TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6VQLB Q9NWZ3 163 458 460.0 R7S:501 Type1 Inactive DFGin 6.8966 14.2148 BLAminus -126.69, 171.91 63.96, 89.58 -112.73, 19.19 306.74, 94.98 -66.69, -28.16 in-out in 8.9822 Saltbr-out 5.741 HRD-in -62.48, -51.55 75.13, -0.71 out-in-in SNCoii in-in ActLoopNT-in 2.8406 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.85, 155.05 APE9-dihe-na 137.23, -167.23 APE8-dihe-in -108.71, 118.9 APE8-rot-in 303.04 APE67-dihe-in -58.51, -22.41 -49.11, -44.93 APE12-dist-in 9.9848 APE11-dist-in 11.6612 APE10-dist-in 6.4733 APE9-dist-in 4.1617 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 B 305.0 286.0 10 30 24 6 [[183, 456]] 1.0 6vql TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6VQLC Q9NWZ3 163 458 460.0 R7S:501 Type1 Inactive DFGin 6.8553 14.2188 BLAminus -132.18, 176.88 62.56, 88.49 -111.96, 18.83 307.92, 94.58 -68.15, -27.83 in-out in 8.914 Saltbr-out 5.6384 HRD-in -60.2, -52.63 76.62, 2.47 out-in-in SNCoii in-in ActLoopNT-in 2.8512 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.63, 152.97 APE9-dihe-na 134.77, -170.05 APE8-dihe-in -109.39, 118.28 APE8-rot-in 304.2 APE67-dihe-in -58.39, -21.83 -47.95, -45.47 APE12-dist-in 10.3271 APE11-dist-in 11.87 APE10-dist-in 6.6051 APE9-dist-in 4.1155 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 C 305.0 287.0 9 30 26 4 [[183, 456]] 1.0 6vql TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6VQLD Q9NWZ3 164 458 460.0 R7S:501 Type1 Inactive DFGin 6.8992 14.2157 BLAminus -132.06, 177.07 63.58, 87.81 -112.09, 19.53 307.29, 95.54 -67.51, -28.65 in-out in 8.8824 Saltbr-out 5.7951 HRD-in -61.98, -52.71 76.16, 3.96 out-in-in SNCoii in-in ActLoopNT-in 2.8477 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.0, 154.7 APE9-dihe-na 133.81, -169.11 APE8-dihe-in -109.98, 117.79 APE8-rot-in 303.11 APE67-dihe-in -57.87, -22.08 -46.74, -46.13 APE12-dist-in 10.0605 APE11-dist-in 11.8494 APE10-dist-in 6.607 APE9-dist-in 4.1195 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 D 305.0 287.0 8 30 27 3 [[183, 456]] 1.0 6vql TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 6VQL — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6VQLA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 6VQLA Q9NWZ3 162 458 460.0 R7S:501 Type1 Inactive DFGin 6.9484 14.1016 BLAminus -128.89, 178.86 62.54, 89.32 -112.77, 19.41 307.7, 95.35 -67.01, -28.48 in-out in 8.8675 Saltbr-out 5.76 HRD-in -60.86, -51.23 73.74, 13.24 out-in-in SNCoii in-in ActLoopNT-in 2.8492 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.6, 156.29 APE9-dihe-na 133.29, -167.61 APE8-dihe-in -110.06, 117.8 APE8-rot-in 304.32 APE67-dihe-in -57.05, -22.07 -48.75, -46.61 APE12-dist-in 10.1761 APE11-dist-in 11.8072 APE10-dist-in 6.649 APE9-dist-in 4.2808 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 A 305.0 289.0 8 30 24 6 [[183, 456]] 1.0 6vql Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6VQLB Q9NWZ3 163 458 460.0 R7S:501 Type1 Inactive DFGin 6.8966 14.2148 BLAminus -126.69, 171.91 63.96, 89.58 -112.73, 19.19 306.74, 94.98 -66.69, -28.16 in-out in 8.9822 Saltbr-out 5.741 HRD-in -62.48, -51.55 75.13, -0.71 out-in-in SNCoii in-in ActLoopNT-in 2.8406 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.85, 155.05 APE9-dihe-na 137.23, -167.23 APE8-dihe-in -108.71, 118.9 APE8-rot-in 303.04 APE67-dihe-in -58.51, -22.41 -49.11, -44.93 APE12-dist-in 9.9848 APE11-dist-in 11.6612 APE10-dist-in 6.4733 APE9-dist-in 4.1617 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 B 305.0 286.0 10 30 24 6 [[183, 456]] 1.0 6vql Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6VQLC Q9NWZ3 163 458 460.0 R7S:501 Type1 Inactive DFGin 6.8553 14.2188 BLAminus -132.18, 176.88 62.56, 88.49 -111.96, 18.83 307.92, 94.58 -68.15, -27.83 in-out in 8.914 Saltbr-out 5.6384 HRD-in -60.2, -52.63 76.62, 2.47 out-in-in SNCoii in-in ActLoopNT-in 2.8512 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.63, 152.97 APE9-dihe-na 134.77, -170.05 APE8-dihe-in -109.39, 118.28 APE8-rot-in 304.2 APE67-dihe-in -58.39, -21.83 -47.95, -45.47 APE12-dist-in 10.3271 APE11-dist-in 11.87 APE10-dist-in 6.6051 APE9-dist-in 4.1155 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 C 305.0 287.0 9 30 26 4 [[183, 456]] 1.0 6vql Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6VQLD Q9NWZ3 164 458 460.0 R7S:501 Type1 Inactive DFGin 6.8992 14.2157 BLAminus -132.06, 177.07 63.58, 87.81 -112.09, 19.53 307.29, 95.54 -67.51, -28.65 in-out in 8.8824 Saltbr-out 5.7951 HRD-in -61.98, -52.71 76.16, 3.96 out-in-in SNCoii in-in ActLoopNT-in 2.8477 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.0, 154.7 APE9-dihe-na 133.81, -169.11 APE8-dihe-in -109.98, 117.79 APE8-rot-in 303.11 APE67-dihe-in -57.87, -22.08 -46.74, -46.13 APE12-dist-in 10.0605 APE11-dist-in 11.8494 APE10-dist-in 6.607 APE9-dist-in 4.1195 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.069 0.244 0.279 D 305.0 287.0 8 30 27 3 [[183, 456]] 1.0 6vql Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 6VQL — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name