| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | TYK2-1 | TYK2_HUMAN | 6NZRA | P29597 | 578 | 867 | 1187.0 | LAJ:901 | Type1 | Pseudo | DFGin | 7.7767 | 12.7807 | None | -69.45, 168.07 | -65.99, 154.27 | -73.6, -4.41 | 23.84, 151.16 | 77.17, -140.45 | in-na | in | 9.4351 | Saltbr-na | 999.0 | HRD-in | -82.75, -62.0 | 89.42, -4.52 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.0946 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -58.36, -40.74 | APE9-dihe-out | -63.5, -26.3 | APE8-dihe-out | -83.27, -1.28 | APE8-rot-na | 205.99 | APE67-dihe-out | -86.49, -0.68 | -74.39, 134.15 | APE12-dist-na | 9.7117 | APE11-dist-na | 12.1953 | APE10-dist-na | 16.3588 | APE9-dist-out | 11.5527 | None | None | None | XRAY | 2.56 | 0.19 | 0.229 | A | 317.0 | 260.0 | 31 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nzr | TYR_TYK2-1_HUMAN | TYR | 3e-60 | 209.8 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| TYR | TYK2-1 | TYK2_HUMAN | 6NZRB | P29597 | 580 | 868 | 1187.0 | LAJ:901 | Type1 | Pseudo | DFGin | 7.7942 | 12.7348 | None | -69.51, 167.49 | -66.18, 155.4 | -74.3, -4.56 | 23.99, 151.21 | 77.6, -139.58 | in-na | in | 9.3707 | Saltbr-na | 999.0 | HRD-in | -85.74, -61.72 | 89.77, -6.44 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.1637 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -58.72, -41.32 | APE9-dihe-out | -63.03, -22.95 | APE8-dihe-out | -84.92, -4.81 | APE8-rot-na | 227.24 | APE67-dihe-out | -86.54, 0.37 | -71.84, 134.55 | APE12-dist-na | 9.7055 | APE11-dist-na | 12.2225 | APE10-dist-na | 16.3775 | APE9-dist-out | 11.5502 | None | None | None | XRAY | 2.56 | 0.19 | 0.229 | B | 317.0 | 259.0 | 30 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nzr | TYR_TYK2-1_HUMAN | TYR | 3e-60 | 209.8 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | TYK2-1 | TYK2_HUMAN | 6NZRA | P29597 | 578 | 867 | 1187.0 | LAJ:901 | Type1 | Pseudo | DFGin | 7.7767 | 12.7807 | None | -69.45, 168.07 | -65.99, 154.27 | -73.6, -4.41 | 23.84, 151.16 | 77.17, -140.45 | in-na | in | 9.4351 | Saltbr-na | 999.0 | HRD-in | -82.75, -62.0 | 89.42, -4.52 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.0946 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -58.36, -40.74 | APE9-dihe-out | -63.5, -26.3 | APE8-dihe-out | -83.27, -1.28 | APE8-rot-na | 205.99 | APE67-dihe-out | -86.49, -0.68 | -74.39, 134.15 | APE12-dist-na | 9.7117 | APE11-dist-na | 12.1953 | APE10-dist-na | 16.3588 | APE9-dist-out | 11.5527 | None | None | None | XRAY | 2.56 | 0.19 | 0.229 | A | 317.0 | 260.0 | 31 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nzr | Homo sapiens | TYR_TYK2-1_HUMAN | TYR | 3e-60 | 209.8 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| TYR | TYK2-1 | TYK2_HUMAN | 6NZRB | P29597 | 580 | 868 | 1187.0 | LAJ:901 | Type1 | Pseudo | DFGin | 7.7942 | 12.7348 | None | -69.51, 167.49 | -66.18, 155.4 | -74.3, -4.56 | 23.99, 151.21 | 77.6, -139.58 | in-na | in | 9.3707 | Saltbr-na | 999.0 | HRD-in | -85.74, -61.72 | 89.77, -6.44 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.1637 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -58.72, -41.32 | APE9-dihe-out | -63.03, -22.95 | APE8-dihe-out | -84.92, -4.81 | APE8-rot-na | 227.24 | APE67-dihe-out | -86.54, 0.37 | -71.84, 134.55 | APE12-dist-na | 9.7055 | APE11-dist-na | 12.2225 | APE10-dist-na | 16.3775 | APE9-dist-out | 11.5502 | None | None | None | XRAY | 2.56 | 0.19 | 0.229 | B | 317.0 | 259.0 | 30 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nzr | Homo sapiens | TYR_TYK2-1_HUMAN | TYR | 3e-60 | 209.8 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|