| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | TYK2-1 | TYK2_HUMAN | 6NZFA | P29597 | 580 | 865 | 1187.0 | L91:901 | Type1 | Pseudo | DFGin | 7.5997 | 12.6706 | None | -71.29, 168.26 | -64.87, 155.03 | -75.86, -3.47 | 25.03, 153.09 | 77.38, -149.91 | in-na | in | 9.4012 | Saltbr-na | 999.0 | HRD-in | -80.34, -62.67 | 82.96, 5.24 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.0939 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -65.48, -39.01 | APE9-dihe-out | -62.83, -25.44 | APE8-dihe-out | -82.23, -7.85 | APE8-rot-na | 215.68 | APE67-dihe-out | -92.43, 5.04 | -68.27, 132.64 | APE12-dist-na | 9.8083 | APE11-dist-na | 12.2624 | APE10-dist-na | 16.5169 | APE9-dist-out | 11.6235 | None | None | None | XRAY | 2.39 | 0.205 | 0.231 | A | 317.0 | 247.0 | 42 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nzf | TYR_TYK2-1_HUMAN | TYR | 5.4e-60 | 208.9 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| TYR | TYK2-1 | TYK2_HUMAN | 6NZFB | P29597 | 580 | 867 | 1187.0 | L91:901 | Type1 | Pseudo | DFGin | 7.6703 | 12.5979 | None | -70.84, 168.4 | -64.97, 153.82 | -75.67, -2.7 | 25.33, 152.34 | 77.04, -149.81 | in-na | in | 9.3721 | Saltbr-na | 999.0 | HRD-in | -81.43, -61.17 | 83.19, 3.8 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.1122 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -65.59, -38.89 | APE9-dihe-out | -62.81, -25.28 | APE8-dihe-out | -84.37, -2.23 | APE8-rot-na | 213.59 | APE67-dihe-out | -91.99, 5.73 | -72.88, 133.85 | APE12-dist-na | 9.7519 | APE11-dist-na | 12.2295 | APE10-dist-na | 16.478 | APE9-dist-out | 11.5547 | None | None | None | XRAY | 2.39 | 0.205 | 0.231 | B | 317.0 | 248.0 | 41 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nzf | TYR_TYK2-1_HUMAN | TYR | 5.4e-60 | 208.9 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | TYK2-1 | TYK2_HUMAN | 6NZFA | P29597 | 580 | 865 | 1187.0 | L91:901 | Type1 | Pseudo | DFGin | 7.5997 | 12.6706 | None | -71.29, 168.26 | -64.87, 155.03 | -75.86, -3.47 | 25.03, 153.09 | 77.38, -149.91 | in-na | in | 9.4012 | Saltbr-na | 999.0 | HRD-in | -80.34, -62.67 | 82.96, 5.24 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.0939 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -65.48, -39.01 | APE9-dihe-out | -62.83, -25.44 | APE8-dihe-out | -82.23, -7.85 | APE8-rot-na | 215.68 | APE67-dihe-out | -92.43, 5.04 | -68.27, 132.64 | APE12-dist-na | 9.8083 | APE11-dist-na | 12.2624 | APE10-dist-na | 16.5169 | APE9-dist-out | 11.6235 | None | None | None | XRAY | 2.39 | 0.205 | 0.231 | A | 317.0 | 247.0 | 42 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nzf | Homo sapiens | TYR_TYK2-1_HUMAN | TYR | 5.4e-60 | 208.9 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| TYR | TYK2-1 | TYK2_HUMAN | 6NZFB | P29597 | 580 | 867 | 1187.0 | L91:901 | Type1 | Pseudo | DFGin | 7.6703 | 12.5979 | None | -70.84, 168.4 | -64.97, 153.82 | -75.67, -2.7 | 25.33, 152.34 | 77.04, -149.81 | in-na | in | 9.3721 | Saltbr-na | 999.0 | HRD-in | -81.43, -61.17 | 83.19, 3.8 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.1122 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -65.59, -38.89 | APE9-dihe-out | -62.81, -25.28 | APE8-dihe-out | -84.37, -2.23 | APE8-rot-na | 213.59 | APE67-dihe-out | -91.99, 5.73 | -72.88, 133.85 | APE12-dist-na | 9.7519 | APE11-dist-na | 12.2295 | APE10-dist-na | 16.478 | APE9-dist-out | 11.5547 | None | None | None | XRAY | 2.39 | 0.205 | 0.231 | B | 317.0 | 248.0 | 41 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nzf | Homo sapiens | TYR_TYK2-1_HUMAN | TYR | 5.4e-60 | 208.9 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|