| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | TYK2-1 | TYK2_HUMAN | 6NSLA | P29597 | 581 | 866 | 1187.0 | KZJ:901 | Type1 | Pseudo | DFGin | 7.4466 | 12.6266 | None | -65.67, 163.1 | -59.9, 147.3 | -72.43, 0.95 | 25.4, 149.24 | 71.0, -150.31 | in-na | in | 9.4495 | Saltbr-na | 999.0 | HRD-in | -79.19, -61.15 | 86.61, -0.76 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.317 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -66.34, -39.28 | APE9-dihe-out | -63.02, -22.39 | APE8-dihe-out | -82.22, -10.35 | APE8-rot-na | 292.93 | APE67-dihe-out | -91.53, -2.04 | -67.32, 133.05 | APE12-dist-na | 9.7215 | APE11-dist-na | 12.197 | APE10-dist-na | 16.4126 | APE9-dist-out | 11.6997 | None | None | None | XRAY | 2.15 | 0.203 | 0.213 | A | 317.0 | 251.0 | 37 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nsl | TYR_TYK2-1_HUMAN | TYR | 5.4e-60 | 208.9 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| TYR | TYK2-1 | TYK2_HUMAN | 6NSLB | P29597 | 581 | 867 | 1187.0 | KZJ:901 | Type1 | Pseudo | DFGin | 7.4662 | 12.5425 | None | -65.53, 162.68 | -58.2, 146.74 | -72.38, 1.37 | 25.74, 148.82 | 71.06, -152.3 | in-na | in | 9.4228 | Saltbr-na | 999.0 | HRD-in | -80.39, -61.97 | 87.32, -2.61 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.2412 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -66.57, -38.38 | APE9-dihe-out | -63.64, -23.52 | APE8-dihe-out | -84.88, -4.11 | APE8-rot-na | 200.51 | APE67-dihe-out | -91.36, -1.36 | -71.83, 133.14 | APE12-dist-na | 9.6668 | APE11-dist-na | 12.1774 | APE10-dist-na | 16.3911 | APE9-dist-out | 11.5683 | None | None | None | XRAY | 2.15 | 0.203 | 0.213 | B | 317.0 | 248.0 | 40 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nsl | TYR_TYK2-1_HUMAN | TYR | 5.4e-60 | 208.9 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | TYK2-1 | TYK2_HUMAN | 6NSLA | P29597 | 581 | 866 | 1187.0 | KZJ:901 | Type1 | Pseudo | DFGin | 7.4466 | 12.6266 | None | -65.67, 163.1 | -59.9, 147.3 | -72.43, 0.95 | 25.4, 149.24 | 71.0, -150.31 | in-na | in | 9.4495 | Saltbr-na | 999.0 | HRD-in | -79.19, -61.15 | 86.61, -0.76 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.317 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -66.34, -39.28 | APE9-dihe-out | -63.02, -22.39 | APE8-dihe-out | -82.22, -10.35 | APE8-rot-na | 292.93 | APE67-dihe-out | -91.53, -2.04 | -67.32, 133.05 | APE12-dist-na | 9.7215 | APE11-dist-na | 12.197 | APE10-dist-na | 16.4126 | APE9-dist-out | 11.6997 | None | None | None | XRAY | 2.15 | 0.203 | 0.213 | A | 317.0 | 251.0 | 37 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nsl | Homo sapiens | TYR_TYK2-1_HUMAN | TYR | 5.4e-60 | 208.9 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| TYR | TYK2-1 | TYK2_HUMAN | 6NSLB | P29597 | 581 | 867 | 1187.0 | KZJ:901 | Type1 | Pseudo | DFGin | 7.4662 | 12.5425 | None | -65.53, 162.68 | -58.2, 146.74 | -72.38, 1.37 | 25.74, 148.82 | 71.06, -152.3 | in-na | in | 9.4228 | Saltbr-na | 999.0 | HRD-in | -80.39, -61.97 | 87.32, -2.61 | na-out-out | SNCaoo | out-out | ActLoopNT-out | 8.2412 | ActLoopCT-out | TYR | APEdihe_oooao | APEdist_aaao | APE10-dihe-out | -66.57, -38.38 | APE9-dihe-out | -63.64, -23.52 | APE8-dihe-out | -84.88, -4.11 | APE8-rot-na | 200.51 | APE67-dihe-out | -91.36, -1.36 | -71.83, 133.14 | APE12-dist-na | 9.6668 | APE11-dist-na | 12.1774 | APE10-dist-na | 16.3911 | APE9-dist-out | 11.5683 | None | None | None | XRAY | 2.15 | 0.203 | 0.213 | B | 317.0 | 248.0 | 40 | 24 | 24 | 0 | [[589, 868], [897, 1171]] | 2.0 | 6nsl | Homo sapiens | TYR_TYK2-1_HUMAN | TYR | 5.4e-60 | 208.9 | 2.0 | 260.0 | 259.0 | 758 | 759 | 760 | 762 | 764 | 642 | 658 | 662 | 731 | 733 | 732 | 734.0 | 796 | 782 | 777 | 776 | 775 | 774 | 773 | 772 | 771 | 688 | Non-receptor tyrosine-protein kinase TYK2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|