PDB: 5T1S — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5T1SC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 5T1SA Q9NWZ3 163 459 460.0 76Q:9901 Type1 Inactive DFGin 6.9238 14.2156 BLAminus -131.2, 172.67 63.25, 85.32 -103.49, 19.58 304.94, 98.19 -62.83, -37.96 in-out in 8.3968 Saltbr-out 4.3357 HRD-in -67.98, -50.93 78.51, -4.97 out-in-in SNCoii in-in ActLoopNT-in 2.7268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.42, 155.39 APE9-dihe-na 136.97, -168.9 APE8-dihe-in -113.04, 114.06 APE8-rot-in 312.08 APE67-dihe-in -62.34, -17.03 -41.2, -52.01 APE12-dist-in 10.2827 APE11-dist-in 11.6358 APE10-dist-in 6.2313 APE9-dist-in 3.7723 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 A 301.0 283.0 14 30 27 3 [[183, 456]] 1.0 5t1s TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5T1SC Q9NWZ3 164 460 460.0 76Q:9901 Type1 Inactive DFGin 6.925 14.585 BLAminus -131.08, 172.79 63.77, 84.62 -102.6, 19.98 305.07, 98.68 -62.65, -38.92 in-out in 9.0801 Saltbr-out 5.1382 HRD-in -67.96, -50.84 78.65, -4.29 out-in-in SNCoii in-in ActLoopNT-in 2.7708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.17, 155.14 APE9-dihe-na 137.47, -168.59 APE8-dihe-in -112.75, 113.96 APE8-rot-in 311.75 APE67-dihe-in -62.32, -17.93 -40.65, -52.04 APE12-dist-in 9.7709 APE11-dist-in 11.6606 APE10-dist-in 6.2474 APE9-dist-in 3.771 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 C 301.0 287.0 10 30 25 5 [[183, 456]] 1.0 5t1s TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5T1SD Q9NWZ3 164 459 460.0 76Q:9901 Type1 Active DFGin 6.951 14.2485 BLAminus -130.82, 172.71 63.6, 85.49 -103.7, 19.85 304.96, 98.34 -62.88, -38.58 in-in in 8.7924 Saltbr-in 3.1253 HRD-in -67.81, -51.47 79.11, -4.9 in-in-in SNCiii in-in ActLoopNT-in 2.7702 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.3, 155.38 APE9-dihe-na 137.43, -168.44 APE8-dihe-in -112.84, 114.02 APE8-rot-in 311.54 APE67-dihe-in -62.52, -17.13 -40.93, -51.81 APE12-dist-in 9.9302 APE11-dist-in 11.6365 APE10-dist-in 6.235 APE9-dist-in 3.7867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 D 301.0 284.0 12 30 25 5 [[183, 456]] 1.0 5t1s TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5T1SB Q9NWZ3 161 459 460.0 76Q:9901 Type1.5_Back Active DFGin 6.8475 14.1018 BLAminus -131.29, 172.67 63.73, 85.01 -103.62, 20.27 304.8, 98.39 -63.0, -38.49 in-in in 8.7432 Saltbr-in 2.8534 HRD-in -68.0, -50.7 78.25, -4.83 in-in-in SNCiii in-in ActLoopNT-in 2.7693 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.12, 154.96 APE9-dihe-na 137.49, -168.77 APE8-dihe-in -112.44, 114.13 APE8-rot-in 311.51 APE67-dihe-in -62.57, -16.72 -41.02, -52.25 APE12-dist-in 9.8992 APE11-dist-in 11.6424 APE10-dist-in 6.2292 APE9-dist-in 3.7675 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 B 301.0 285.0 14 30 25 5 [[183, 456]] 1.0 5t1s TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 5T1S — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5T1SC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 5T1SA Q9NWZ3 163 459 460.0 76Q:9901 Type1 Inactive DFGin 6.9238 14.2156 BLAminus -131.2, 172.67 63.25, 85.32 -103.49, 19.58 304.94, 98.19 -62.83, -37.96 in-out in 8.3968 Saltbr-out 4.3357 HRD-in -67.98, -50.93 78.51, -4.97 out-in-in SNCoii in-in ActLoopNT-in 2.7268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.42, 155.39 APE9-dihe-na 136.97, -168.9 APE8-dihe-in -113.04, 114.06 APE8-rot-in 312.08 APE67-dihe-in -62.34, -17.03 -41.2, -52.01 APE12-dist-in 10.2827 APE11-dist-in 11.6358 APE10-dist-in 6.2313 APE9-dist-in 3.7723 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 A 301.0 283.0 14 30 27 3 [[183, 456]] 1.0 5t1s Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5T1SC Q9NWZ3 164 460 460.0 76Q:9901 Type1 Inactive DFGin 6.925 14.585 BLAminus -131.08, 172.79 63.77, 84.62 -102.6, 19.98 305.07, 98.68 -62.65, -38.92 in-out in 9.0801 Saltbr-out 5.1382 HRD-in -67.96, -50.84 78.65, -4.29 out-in-in SNCoii in-in ActLoopNT-in 2.7708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.17, 155.14 APE9-dihe-na 137.47, -168.59 APE8-dihe-in -112.75, 113.96 APE8-rot-in 311.75 APE67-dihe-in -62.32, -17.93 -40.65, -52.04 APE12-dist-in 9.7709 APE11-dist-in 11.6606 APE10-dist-in 6.2474 APE9-dist-in 3.771 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 C 301.0 287.0 10 30 25 5 [[183, 456]] 1.0 5t1s Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5T1SD Q9NWZ3 164 459 460.0 76Q:9901 Type1 Active DFGin 6.951 14.2485 BLAminus -130.82, 172.71 63.6, 85.49 -103.7, 19.85 304.96, 98.34 -62.88, -38.58 in-in in 8.7924 Saltbr-in 3.1253 HRD-in -67.81, -51.47 79.11, -4.9 in-in-in SNCiii in-in ActLoopNT-in 2.7702 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.3, 155.38 APE9-dihe-na 137.43, -168.44 APE8-dihe-in -112.84, 114.02 APE8-rot-in 311.54 APE67-dihe-in -62.52, -17.13 -40.93, -51.81 APE12-dist-in 9.9302 APE11-dist-in 11.6365 APE10-dist-in 6.235 APE9-dist-in 3.7867 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 D 301.0 284.0 12 30 25 5 [[183, 456]] 1.0 5t1s Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5T1SB Q9NWZ3 161 459 460.0 76Q:9901 Type1.5_Back Active DFGin 6.8475 14.1018 BLAminus -131.29, 172.67 63.73, 85.01 -103.62, 20.27 304.8, 98.39 -63.0, -38.49 in-in in 8.7432 Saltbr-in 2.8534 HRD-in -68.0, -50.7 78.25, -4.83 in-in-in SNCiii in-in ActLoopNT-in 2.7693 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.12, 154.96 APE9-dihe-na 137.49, -168.77 APE8-dihe-in -112.44, 114.13 APE8-rot-in 311.51 APE67-dihe-in -62.57, -16.72 -41.02, -52.25 APE12-dist-in 9.8992 APE11-dist-in 11.6424 APE10-dist-in 6.2292 APE9-dist-in 3.7675 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.207 0.223 B 301.0 285.0 14 30 25 5 [[183, 456]] 1.0 5t1s Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 5T1S — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name