PDB: 5HEZ — TYR JAK2_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 5HEZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 5HEZA O60674 842 1132 1132.0 1M3:1203,1M3:1204 Allosteric,Type1 Inactive DFGin 6.1813 13.5762 ABAminus -103.67, 3.96 -149.83, 138.2 -131.72, 28.65 300.8, 91.99 -61.15, -26.6 in-in in 8.2962 Saltbr-in 2.7425 HRD-in -60.6, -48.83 77.58, -20.92 in-in-out SNCiio in-out ActLoopNT-in 2.8258 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -93.22, 48.54 APE9-dihe-in -69.64, 140.78 APE8-dihe-out -72.52, 2.67 APE8-rot-na 25.71 APE67-dihe-out -117.46, -52.02 -67.01, 128.79 APE12-dist-na 14.5795 APE11-dist-na 11.3166 APE10-dist-na 12.2683 APE9-dist-out 8.3722 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 A 302.0 289.0 2 31 31 0 [[545, 807], [849, 1125]] 2.0 5hez TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5HEZB O60674 842 1132 1132.0 1M3:1202,1M3:1203 Allosteric,Type1 Inactive DFGin 6.1909 13.5273 ABAminus -103.41, 2.96 -148.35, 138.17 -130.74, 29.01 299.81, 93.06 -60.8, -25.75 in-in in 8.3238 Saltbr-in 2.7425 HRD-in -61.03, -48.59 78.08, -21.43 in-in-out SNCiio in-out ActLoopNT-in 2.8241 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out 45.93, 11.51 APE9-dihe-in -79.34, 131.16 APE8-dihe-out -79.25, -1.75 APE8-rot-na 28.01 APE67-dihe-out -118.77, -49.59 -69.25, 127.98 APE12-dist-na 12.4531 APE11-dist-na 13.4124 APE10-dist-na 12.3642 APE9-dist-out 8.9399 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 B 302.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 5hez TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5HEZD O60674 842 1132 1132.0 1M3:1202,1M3:1203 Allosteric,Type1 Inactive DFGin 6.1887 13.5379 ABAminus -102.35, 3.11 -149.37, 138.24 -132.2, 28.53 300.15, 93.07 -59.55, -26.76 in-in in 8.3018 Saltbr-in 2.7765 HRD-in -60.7, -48.85 78.34, -23.62 in-in-out SNCiio in-out ActLoopNT-in 2.8175 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -170.07, -9.93 APE9-dihe-in -55.73, 129.12 APE8-dihe-out -79.78, -1.34 APE8-rot-na 27.62 APE67-dihe-out -118.44, -49.74 -68.49, 127.41 APE12-dist-na 10.8937 APE11-dist-na 13.8358 APE10-dist-na 11.8438 APE9-dist-out 8.9217 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 D 302.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 5hez TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5HEZC O60674 842 1132 1132.0 1M3:1201,1M3:1202 Type1,Allosteric Inactive DFGin 6.167 13.5695 ABAminus -103.82, 3.86 -148.69, 138.92 -132.75, 28.94 299.92, 92.74 -60.0, -27.11 in-in in 8.2872 Saltbr-in 2.7473 HRD-in -60.66, -47.83 77.19, -22.6 in-in-out SNCiio in-out ActLoopNT-in 2.8174 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -104.85, 22.51 APE9-dihe-in -86.59, 123.97 APE8-dihe-out -80.09, -0.5 APE8-rot-na 27.2 APE67-dihe-out -118.37, -51.6 -67.71, 128.02 APE12-dist-na 10.9036 APE11-dist-na 13.3744 APE10-dist-na 11.2808 APE9-dist-out 8.8539 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 C 302.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 5hez TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

PDB: 5HEZ — TYR JAK2_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 5HEZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 5HEZA O60674 842 1132 1132.0 1M3:1203,1M3:1204 Allosteric,Type1 Inactive DFGin 6.1813 13.5762 ABAminus -103.67, 3.96 -149.83, 138.2 -131.72, 28.65 300.8, 91.99 -61.15, -26.6 in-in in 8.2962 Saltbr-in 2.7425 HRD-in -60.6, -48.83 77.58, -20.92 in-in-out SNCiio in-out ActLoopNT-in 2.8258 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -93.22, 48.54 APE9-dihe-in -69.64, 140.78 APE8-dihe-out -72.52, 2.67 APE8-rot-na 25.71 APE67-dihe-out -117.46, -52.02 -67.01, 128.79 APE12-dist-na 14.5795 APE11-dist-na 11.3166 APE10-dist-na 12.2683 APE9-dist-out 8.3722 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 A 302.0 289.0 2 31 31 0 [[545, 807], [849, 1125]] 2.0 5hez Homo sapiens TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5HEZB O60674 842 1132 1132.0 1M3:1202,1M3:1203 Allosteric,Type1 Inactive DFGin 6.1909 13.5273 ABAminus -103.41, 2.96 -148.35, 138.17 -130.74, 29.01 299.81, 93.06 -60.8, -25.75 in-in in 8.3238 Saltbr-in 2.7425 HRD-in -61.03, -48.59 78.08, -21.43 in-in-out SNCiio in-out ActLoopNT-in 2.8241 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out 45.93, 11.51 APE9-dihe-in -79.34, 131.16 APE8-dihe-out -79.25, -1.75 APE8-rot-na 28.01 APE67-dihe-out -118.77, -49.59 -69.25, 127.98 APE12-dist-na 12.4531 APE11-dist-na 13.4124 APE10-dist-na 12.3642 APE9-dist-out 8.9399 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 B 302.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 5hez Homo sapiens TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5HEZD O60674 842 1132 1132.0 1M3:1202,1M3:1203 Allosteric,Type1 Inactive DFGin 6.1887 13.5379 ABAminus -102.35, 3.11 -149.37, 138.24 -132.2, 28.53 300.15, 93.07 -59.55, -26.76 in-in in 8.3018 Saltbr-in 2.7765 HRD-in -60.7, -48.85 78.34, -23.62 in-in-out SNCiio in-out ActLoopNT-in 2.8175 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -170.07, -9.93 APE9-dihe-in -55.73, 129.12 APE8-dihe-out -79.78, -1.34 APE8-rot-na 27.62 APE67-dihe-out -118.44, -49.74 -68.49, 127.41 APE12-dist-na 10.8937 APE11-dist-na 13.8358 APE10-dist-na 11.8438 APE9-dist-out 8.9217 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 D 302.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 5hez Homo sapiens TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5HEZC O60674 842 1132 1132.0 1M3:1201,1M3:1202 Type1,Allosteric Inactive DFGin 6.167 13.5695 ABAminus -103.82, 3.86 -148.69, 138.92 -132.75, 28.94 299.92, 92.74 -60.0, -27.11 in-in in 8.2872 Saltbr-in 2.7473 HRD-in -60.66, -47.83 77.19, -22.6 in-in-out SNCiio in-out ActLoopNT-in 2.8174 ActLoopCT-out TYR APEdihe_oioao APEdist_aaao APE10-dihe-out -104.85, 22.51 APE9-dihe-in -86.59, 123.97 APE8-dihe-out -80.09, -0.5 APE8-rot-na 27.2 APE67-dihe-out -118.37, -51.6 -67.71, 128.02 APE12-dist-na 10.9036 APE11-dist-na 13.3744 APE10-dist-na 11.2808 APE9-dist-out 8.8539 P1057A PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.66 0.218 0.238 C 302.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 5hez Homo sapiens TYR_JAK2-2_HUMAN TYR 3.7e-87 297.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

PDB: 5HEZ — TYR JAK2_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name