PDB: 4ZTN — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4ZTNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 4ZTNA Q9NWZ3 163 459 460.0 4S3:501 Type1 Inactive DFGin 6.9122 13.7481 BLAminus -132.76, 175.45 64.22, 82.16 -105.35, 20.86 308.35, 101.07 -66.05, -41.88 in-out in 8.6944 Saltbr-out 3.9124 HRD-in -63.92, -51.66 76.82, -0.35 out-in-in SNCoii in-in ActLoopNT-in 2.7616 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.06, 158.04 APE9-dihe-na 129.58, -170.0 APE8-dihe-in -113.45, 112.1 APE8-rot-in 310.07 APE67-dihe-in -62.7, -20.05 -38.09, -52.45 APE12-dist-in 9.814 APE11-dist-in 11.7179 APE10-dist-in 6.2346 APE9-dist-in 3.8197 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 A 301.0 289.0 8 30 26 4 [[183, 456]] 1.0 4ztn TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4ZTNB Q9NWZ3 161 459 460.0 4S3:501 Type1 Active DFGin 7.1545 13.7575 BLAminus -131.99, 175.82 63.87, 82.48 -105.73, 21.47 308.39, 101.43 -66.39, -41.59 in-in in 8.5507 Saltbr-in 3.2983 HRD-in -64.32, -51.43 76.6, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.7675 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.02, 158.22 APE9-dihe-na 130.01, -170.09 APE8-dihe-in -112.61, 111.91 APE8-rot-in 309.6 APE67-dihe-in -62.86, -20.33 -37.78, -52.13 APE12-dist-in 9.8586 APE11-dist-in 11.7313 APE10-dist-in 6.2358 APE9-dist-in 3.8196 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 B 301.0 285.0 14 30 26 4 [[183, 456]] 1.0 4ztn TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4ZTNC Q9NWZ3 164 460 460.0 4S3:501 Type1 Inactive DFGin 6.9885 13.9156 BLAminus -131.78, 175.79 64.01, 82.42 -105.46, 21.38 307.95, 100.83 -65.91, -41.86 in-out in 8.7626 Saltbr-out 5.2416 HRD-in -64.24, -51.41 76.71, -0.47 out-in-in SNCoii in-in ActLoopNT-in 2.7669 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.03, 158.37 APE9-dihe-na 130.24, -169.83 APE8-dihe-in -112.97, 111.72 APE8-rot-in 309.39 APE67-dihe-in -62.29, -20.6 -37.85, -52.05 APE12-dist-in 9.8427 APE11-dist-in 11.7416 APE10-dist-in 6.2439 APE9-dist-in 3.8114 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 C 301.0 287.0 10 30 25 5 [[183, 456]] 1.0 4ztn TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4ZTND Q9NWZ3 164 459 460.0 4S3:501 Type1 Inactive DFGin 6.9666 13.8616 BLAminus -131.47, 175.86 63.89, 82.53 -105.44, 21.0 308.32, 101.14 -65.65, -42.51 in-out in 8.5619 Saltbr-out 4.5879 HRD-in -64.48, -51.67 77.17, -0.49 out-in-in SNCoii in-in ActLoopNT-in 2.7672 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.0, 157.79 APE9-dihe-na 130.37, -169.74 APE8-dihe-in -112.98, 111.75 APE8-rot-in 309.39 APE67-dihe-in -62.26, -20.04 -38.34, -52.0 APE12-dist-in 9.8419 APE11-dist-in 11.7142 APE10-dist-in 6.2313 APE9-dist-in 3.8469 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4ztn TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 4ZTN — TKL IRAK4_HUMAN

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 4ZTNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 4ZTNA Q9NWZ3 163 459 460.0 4S3:501 Type1 Inactive DFGin 6.9122 13.7481 BLAminus -132.76, 175.45 64.22, 82.16 -105.35, 20.86 308.35, 101.07 -66.05, -41.88 in-out in 8.6944 Saltbr-out 3.9124 HRD-in -63.92, -51.66 76.82, -0.35 out-in-in SNCoii in-in ActLoopNT-in 2.7616 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.06, 158.04 APE9-dihe-na 129.58, -170.0 APE8-dihe-in -113.45, 112.1 APE8-rot-in 310.07 APE67-dihe-in -62.7, -20.05 -38.09, -52.45 APE12-dist-in 9.814 APE11-dist-in 11.7179 APE10-dist-in 6.2346 APE9-dist-in 3.8197 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 A 301.0 289.0 8 30 26 4 [[183, 456]] 1.0 4ztn Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4ZTNB Q9NWZ3 161 459 460.0 4S3:501 Type1 Active DFGin 7.1545 13.7575 BLAminus -131.99, 175.82 63.87, 82.48 -105.73, 21.47 308.39, 101.43 -66.39, -41.59 in-in in 8.5507 Saltbr-in 3.2983 HRD-in -64.32, -51.43 76.6, -0.44 in-in-in SNCiii in-in ActLoopNT-in 2.7675 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.02, 158.22 APE9-dihe-na 130.01, -170.09 APE8-dihe-in -112.61, 111.91 APE8-rot-in 309.6 APE67-dihe-in -62.86, -20.33 -37.78, -52.13 APE12-dist-in 9.8586 APE11-dist-in 11.7313 APE10-dist-in 6.2358 APE9-dist-in 3.8196 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 B 301.0 285.0 14 30 26 4 [[183, 456]] 1.0 4ztn Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4ZTNC Q9NWZ3 164 460 460.0 4S3:501 Type1 Inactive DFGin 6.9885 13.9156 BLAminus -131.78, 175.79 64.01, 82.42 -105.46, 21.38 307.95, 100.83 -65.91, -41.86 in-out in 8.7626 Saltbr-out 5.2416 HRD-in -64.24, -51.41 76.71, -0.47 out-in-in SNCoii in-in ActLoopNT-in 2.7669 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.03, 158.37 APE9-dihe-na 130.24, -169.83 APE8-dihe-in -112.97, 111.72 APE8-rot-in 309.39 APE67-dihe-in -62.29, -20.6 -37.85, -52.05 APE12-dist-in 9.8427 APE11-dist-in 11.7416 APE10-dist-in 6.2439 APE9-dist-in 3.8114 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 C 301.0 287.0 10 30 25 5 [[183, 456]] 1.0 4ztn Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4ZTND Q9NWZ3 164 459 460.0 4S3:501 Type1 Inactive DFGin 6.9666 13.8616 BLAminus -131.47, 175.86 63.89, 82.53 -105.44, 21.0 308.32, 101.14 -65.65, -42.51 in-out in 8.5619 Saltbr-out 4.5879 HRD-in -64.48, -51.67 77.17, -0.49 out-in-in SNCoii in-in ActLoopNT-in 2.7672 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.0, 157.79 APE9-dihe-na 130.37, -169.74 APE8-dihe-in -112.98, 111.75 APE8-rot-in 309.39 APE67-dihe-in -62.26, -20.04 -38.34, -52.0 APE12-dist-in 9.8419 APE11-dist-in 11.7142 APE10-dist-in 6.2313 APE9-dist-in 3.8469 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.23 0.21 0.224 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4ztn Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

PDB: 4ZTN — TKL IRAK4_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name