| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | BTK | Q3ZC95_BOVIN | 4Y95A | Q3ZC95 | 395 | 659 | 659.0 | 746:60701 | Type1 | Inactive | DFGin | 6.6175 | 13.8598 | BLBplus | -121.38, 150.87 | 56.6, 35.77 | -63.21, 129.98 | 38.15, 94.63 | 78.92, -1.55 | out-out | out | 14.6244 | Saltbr-out | 16.1857 | HRD-in | -73.49, -58.3 | 84.27, -8.32 | out-out-out | SNCooo | out-out | ActLoopNT-out | 7.9226 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaao | APE10-dihe-out | -110.52, -5.28 | APE9-dihe-in | -66.23, 137.47 | APE8-dihe-in | -79.05, 62.77 | APE8-rot-na | 30.72 | APE67-dihe-in | -77.89, -2.13 | -54.11, -40.82 | APE12-dist-na | 17.5052 | APE11-dist-na | 19.1412 | APE10-dist-na | 14.0853 | APE9-dist-out | 8.6558 | L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P | None | None | XRAY | 1.599 | 0.155 | 0.184 | A | 266.0 | 265.0 | 0 | 29 | 29 | 0 | [[402, 653]] | 1.0 | 4y95 | Bos taurus | TYR_BTK_BOVIN | TYR | 1.4e-93 | 318.9 | 1.0 | 258.0 | 258.0 | 538 | 539 | 540 | 542 | 544 | 430 | 445 | 449 | 518 | 520 | 519 | 521.0 | 579 | 567 | 562 | 561 | 560 | 559 | 558 | 557 | 556 | 475 | Tyrosine-protein kinase |
| TYR | BTK | Q3ZC95_BOVIN | 4Y95D | Q3ZC95 | 395 | 659 | 659.0 | 746:60701 | Type1 | Inactive | DFGin | 6.6489 | 13.8623 | BLBplus | -120.58, 150.23 | 57.17, 35.26 | -62.33, 130.63 | 38.01, 95.62 | 77.89, -2.4 | out-out | out | 14.6289 | Saltbr-out | 16.219 | HRD-in | -73.6, -57.75 | 84.35, -9.39 | out-out-out | SNCooo | out-out | ActLoopNT-out | 7.9005 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaao | APE10-dihe-out | -110.57, -5.62 | APE9-dihe-in | -65.7, 137.52 | APE8-dihe-in | -78.52, 62.83 | APE8-rot-na | 30.81 | APE67-dihe-in | -77.8, -1.14 | -54.26, -41.32 | APE12-dist-na | 17.5167 | APE11-dist-na | 19.15 | APE10-dist-na | 14.0784 | APE9-dist-out | 8.6269 | L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P | None | None | XRAY | 1.599 | 0.155 | 0.184 | D | 266.0 | 265.0 | 0 | 29 | 29 | 0 | [[402, 653]] | 1.0 | 4y95 | Bos taurus | TYR_BTK_BOVIN | TYR | 1.4e-93 | 318.9 | 1.0 | 258.0 | 258.0 | 538 | 539 | 540 | 542 | 544 | 430 | 445 | 449 | 518 | 520 | 519 | 521.0 | 579 | 567 | 562 | 561 | 560 | 559 | 558 | 557 | 556 | 475 | Tyrosine-protein kinase |
| TYR | BTK | Q3ZC95_BOVIN | 4Y95B | Q3ZC95 | 395 | 659 | 659.0 | 746:60701,PE4:60705 | Type1,Allosteric | Inactive | DFGin | 6.2838 | 14.0698 | BLBplus | -118.87, 151.9 | 58.51, 36.48 | -63.81, 131.39 | 36.51, 95.01 | 77.72, -1.04 | out-out | out | 14.5981 | Saltbr-out | 16.1022 | HRD-in | -74.38, -57.15 | 83.98, -6.38 | out-out-out | SNCooo | out-out | ActLoopNT-out | 8.1264 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaao | APE10-dihe-out | -110.28, -7.21 | APE9-dihe-in | -68.34, 135.25 | APE8-dihe-in | -80.18, 64.43 | APE8-rot-na | 29.96 | APE67-dihe-in | -80.41, -0.39 | -53.51, -41.68 | APE12-dist-na | 17.4878 | APE11-dist-na | 18.9412 | APE10-dist-na | 13.9012 | APE9-dist-out | 8.7509 | L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P | None | None | XRAY | 1.599 | 0.155 | 0.184 | B | 266.0 | 265.0 | 0 | 29 | 29 | 0 | [[402, 653]] | 1.0 | 4y95 | Bos taurus | TYR_BTK_BOVIN | TYR | 1.4e-93 | 318.9 | 1.0 | 258.0 | 258.0 | 538 | 539 | 540 | 542 | 544 | 430 | 445 | 449 | 518 | 520 | 519 | 521.0 | 579 | 567 | 562 | 561 | 560 | 559 | 558 | 557 | 556 | 475 | Tyrosine-protein kinase |
| TYR | BTK | Q3ZC95_BOVIN | 4Y95C | Q3ZC95 | 395 | 659 | 659.0 | 746:61001,PE4:61004 | Type1,Allosteric | Inactive | DFGin | 6.2611 | 14.0342 | BLBplus | -119.16, 152.8 | 57.59, 36.19 | -63.2, 130.69 | 37.21, 95.75 | 78.07, -1.63 | out-out | out | 14.6057 | Saltbr-out | 16.1522 | HRD-in | -74.98, -51.44 | 82.75, -9.25 | out-out-out | SNCooo | out-out | ActLoopNT-out | 8.1038 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaao | APE10-dihe-out | -111.01, -6.79 | APE9-dihe-in | -68.05, 136.6 | APE8-dihe-in | -80.31, 63.53 | APE8-rot-na | 30.49 | APE67-dihe-in | -79.73, -0.13 | -53.01, -42.36 | APE12-dist-na | 17.506 | APE11-dist-na | 18.9727 | APE10-dist-na | 13.9266 | APE9-dist-out | 8.8005 | L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P | None | None | XRAY | 1.599 | 0.155 | 0.184 | C | 266.0 | 265.0 | 0 | 29 | 29 | 0 | [[402, 653]] | 1.0 | 4y95 | Bos taurus | TYR_BTK_BOVIN | TYR | 1.4e-93 | 318.9 | 1.0 | 258.0 | 258.0 | 538 | 539 | 540 | 542 | 544 | 430 | 445 | 449 | 518 | 520 | 519 | 521.0 | 579 | 567 | 562 | 561 | 560 | 559 | 558 | 557 | 556 | 475 | Tyrosine-protein kinase |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | BTK | Q3ZC95_BOVIN | 4Y95A | Q3ZC95 | 395 | 659 | 659.0 | 746:60701 | Type1 | Inactive | DFGin | 6.6175 | 13.8598 | BLBplus | -121.38, 150.87 | 56.6, 35.77 | -63.21, 129.98 | 38.15, 94.63 | 78.92, -1.55 | out-out | out | 14.6244 | Saltbr-out | 16.1857 | HRD-in | -73.49, -58.3 | 84.27, -8.32 | out-out-out | SNCooo | out-out | ActLoopNT-out | 7.9226 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaao | APE10-dihe-out | -110.52, -5.28 | APE9-dihe-in | -66.23, 137.47 | APE8-dihe-in | -79.05, 62.77 | APE8-rot-na | 30.72 | APE67-dihe-in | -77.89, -2.13 | -54.11, -40.82 | APE12-dist-na | 17.5052 | APE11-dist-na | 19.1412 | APE10-dist-na | 14.0853 | APE9-dist-out | 8.6558 | L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P | None | None | XRAY | 1.599 | 0.155 | 0.184 | A | 266.0 | 265.0 | 0 | 29 | 29 | 0 | [[402, 653]] | 1.0 | 4y95 | Bos taurus | TYR_BTK_BOVIN | TYR | 1.4e-93 | 318.9 | 1.0 | 258.0 | 258.0 | 538 | 539 | 540 | 542 | 544 | 430 | 445 | 449 | 518 | 520 | 519 | 521.0 | 579 | 567 | 562 | 561 | 560 | 559 | 558 | 557 | 556 | 475 | Tyrosine-protein kinase |
| TYR | BTK | Q3ZC95_BOVIN | 4Y95D | Q3ZC95 | 395 | 659 | 659.0 | 746:60701 | Type1 | Inactive | DFGin | 6.6489 | 13.8623 | BLBplus | -120.58, 150.23 | 57.17, 35.26 | -62.33, 130.63 | 38.01, 95.62 | 77.89, -2.4 | out-out | out | 14.6289 | Saltbr-out | 16.219 | HRD-in | -73.6, -57.75 | 84.35, -9.39 | out-out-out | SNCooo | out-out | ActLoopNT-out | 7.9005 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaao | APE10-dihe-out | -110.57, -5.62 | APE9-dihe-in | -65.7, 137.52 | APE8-dihe-in | -78.52, 62.83 | APE8-rot-na | 30.81 | APE67-dihe-in | -77.8, -1.14 | -54.26, -41.32 | APE12-dist-na | 17.5167 | APE11-dist-na | 19.15 | APE10-dist-na | 14.0784 | APE9-dist-out | 8.6269 | L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P | None | None | XRAY | 1.599 | 0.155 | 0.184 | D | 266.0 | 265.0 | 0 | 29 | 29 | 0 | [[402, 653]] | 1.0 | 4y95 | Bos taurus | TYR_BTK_BOVIN | TYR | 1.4e-93 | 318.9 | 1.0 | 258.0 | 258.0 | 538 | 539 | 540 | 542 | 544 | 430 | 445 | 449 | 518 | 520 | 519 | 521.0 | 579 | 567 | 562 | 561 | 560 | 559 | 558 | 557 | 556 | 475 | Tyrosine-protein kinase |
| TYR | BTK | Q3ZC95_BOVIN | 4Y95B | Q3ZC95 | 395 | 659 | 659.0 | 746:60701,PE4:60705 | Type1,Allosteric | Inactive | DFGin | 6.2838 | 14.0698 | BLBplus | -118.87, 151.9 | 58.51, 36.48 | -63.81, 131.39 | 36.51, 95.01 | 77.72, -1.04 | out-out | out | 14.5981 | Saltbr-out | 16.1022 | HRD-in | -74.38, -57.15 | 83.98, -6.38 | out-out-out | SNCooo | out-out | ActLoopNT-out | 8.1264 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaao | APE10-dihe-out | -110.28, -7.21 | APE9-dihe-in | -68.34, 135.25 | APE8-dihe-in | -80.18, 64.43 | APE8-rot-na | 29.96 | APE67-dihe-in | -80.41, -0.39 | -53.51, -41.68 | APE12-dist-na | 17.4878 | APE11-dist-na | 18.9412 | APE10-dist-na | 13.9012 | APE9-dist-out | 8.7509 | L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P | None | None | XRAY | 1.599 | 0.155 | 0.184 | B | 266.0 | 265.0 | 0 | 29 | 29 | 0 | [[402, 653]] | 1.0 | 4y95 | Bos taurus | TYR_BTK_BOVIN | TYR | 1.4e-93 | 318.9 | 1.0 | 258.0 | 258.0 | 538 | 539 | 540 | 542 | 544 | 430 | 445 | 449 | 518 | 520 | 519 | 521.0 | 579 | 567 | 562 | 561 | 560 | 559 | 558 | 557 | 556 | 475 | Tyrosine-protein kinase |
| TYR | BTK | Q3ZC95_BOVIN | 4Y95C | Q3ZC95 | 395 | 659 | 659.0 | 746:61001,PE4:61004 | Type1,Allosteric | Inactive | DFGin | 6.2611 | 14.0342 | BLBplus | -119.16, 152.8 | 57.59, 36.19 | -63.2, 130.69 | 37.21, 95.75 | 78.07, -1.63 | out-out | out | 14.6057 | Saltbr-out | 16.1522 | HRD-in | -74.98, -51.44 | 82.75, -9.25 | out-out-out | SNCooo | out-out | ActLoopNT-out | 8.1038 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaao | APE10-dihe-out | -111.01, -6.79 | APE9-dihe-in | -68.05, 136.6 | APE8-dihe-in | -80.31, 63.53 | APE8-rot-na | 30.49 | APE67-dihe-in | -79.73, -0.13 | -53.01, -42.36 | APE12-dist-na | 17.506 | APE11-dist-na | 18.9727 | APE10-dist-na | 13.9266 | APE9-dist-out | 8.8005 | L542M,S543T,Y545F,V555T,S557T,R562K,S564A,P565S,Y617P | None | None | XRAY | 1.599 | 0.155 | 0.184 | C | 266.0 | 265.0 | 0 | 29 | 29 | 0 | [[402, 653]] | 1.0 | 4y95 | Bos taurus | TYR_BTK_BOVIN | TYR | 1.4e-93 | 318.9 | 1.0 | 258.0 | 258.0 | 538 | 539 | 540 | 542 | 544 | 430 | 445 | 449 | 518 | 520 | 519 | 521.0 | 579 | 567 | 562 | 561 | 560 | 559 | 558 | 557 | 556 | 475 | Tyrosine-protein kinase |