PDB: 4E4L — TYR JAK1_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 4E4LD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK1-2 JAK1_HUMAN 4E4LE P23458 864 1154 1154.0 No_ligand No_ligand Inactive DFGin 6.4627 13.613 ABAminus -114.05, 7.25 -155.92, 142.83 -135.92, 30.26 296.52, 85.61 -59.94, -28.28 in-in in 7.8702 Saltbr-in 2.6251 HRD-in -76.43, -49.33 70.91, 5.03 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.8, 27.83 APE9-dihe-in -58.48, 132.7 APE8-dihe-in -75.95, 78.2 APE8-rot-na 25.62 APE67-dihe-in -75.39, -5.67 -60.62, -30.34 APE12-dist-na 11.4043 APE11-dist-na 12.8654 APE10-dist-na 10.3351 APE9-dist-in 6.7659 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 E 302.0 282.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 4E4LA P23458 865 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.5059 13.5932 ABAminus -113.26, 1.55 -155.7, 141.31 -133.96, 30.85 296.7, 84.55 -61.93, -29.15 in-in in 7.7283 Saltbr-in 2.3665 HRD-in -82.62, -51.73 77.35, 2.42 in-in-out SNCiio in-out ActLoopNT-in 2.8326 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.62, 29.91 APE9-dihe-in -55.83, 134.62 APE8-dihe-in -77.55, 77.11 APE8-rot-na 23.92 APE67-dihe-in -76.85, -4.17 -58.31, -32.93 APE12-dist-na 11.099 APE11-dist-na 12.7606 APE10-dist-na 10.3479 APE9-dist-in 6.603 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 A 302.0 279.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 4E4LB P23458 864 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.4683 13.6897 ABAminus -115.34, 5.94 -154.23, 143.98 -136.31, 29.8 294.89, 85.73 -63.4, -28.12 in-in in 7.872 Saltbr-in 2.6248 HRD-in -80.23, -45.9 70.61, 1.75 in-in-out SNCiio in-out ActLoopNT-in 2.7501 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.56, 32.84 APE9-dihe-in -59.39, 139.65 APE8-dihe-in -81.36, 75.53 APE8-rot-na 28.93 APE67-dihe-in -77.55, -4.05 -62.31, -27.51 APE12-dist-na 10.9946 APE11-dist-na 12.667 APE10-dist-na 10.0695 APE9-dist-in 6.6324 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 B 302.0 281.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 4E4LD P23458 864 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.5361 13.748 ABAminus -114.27, -0.81 -153.61, 143.22 -135.12, 28.03 293.73, 85.38 -57.66, -27.04 in-in in 7.7412 Saltbr-in 2.5547 HRD-in -77.01, -53.08 75.86, 4.71 in-in-out SNCiio in-out ActLoopNT-in 2.8229 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.68, 33.68 APE9-dihe-in -65.48, 130.64 APE8-dihe-in -74.63, 79.76 APE8-rot-na 26.43 APE67-dihe-in -75.57, -2.67 -62.18, -32.34 APE12-dist-na 11.5127 APE11-dist-na 12.875 APE10-dist-na 10.4155 APE9-dist-in 6.7005 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 D 302.0 283.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1

PDB: 4E4L — TYR JAK1_HUMAN

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 4E4LD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK1-2 JAK1_HUMAN 4E4LE P23458 864 1154 1154.0 No_ligand No_ligand Inactive DFGin 6.4627 13.613 ABAminus -114.05, 7.25 -155.92, 142.83 -135.92, 30.26 296.52, 85.61 -59.94, -28.28 in-in in 7.8702 Saltbr-in 2.6251 HRD-in -76.43, -49.33 70.91, 5.03 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.8, 27.83 APE9-dihe-in -58.48, 132.7 APE8-dihe-in -75.95, 78.2 APE8-rot-na 25.62 APE67-dihe-in -75.39, -5.67 -60.62, -30.34 APE12-dist-na 11.4043 APE11-dist-na 12.8654 APE10-dist-na 10.3351 APE9-dist-in 6.7659 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 E 302.0 282.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 4E4LA P23458 865 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.5059 13.5932 ABAminus -113.26, 1.55 -155.7, 141.31 -133.96, 30.85 296.7, 84.55 -61.93, -29.15 in-in in 7.7283 Saltbr-in 2.3665 HRD-in -82.62, -51.73 77.35, 2.42 in-in-out SNCiio in-out ActLoopNT-in 2.8326 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.62, 29.91 APE9-dihe-in -55.83, 134.62 APE8-dihe-in -77.55, 77.11 APE8-rot-na 23.92 APE67-dihe-in -76.85, -4.17 -58.31, -32.93 APE12-dist-na 11.099 APE11-dist-na 12.7606 APE10-dist-na 10.3479 APE9-dist-in 6.603 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 A 302.0 279.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 4E4LB P23458 864 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.4683 13.6897 ABAminus -115.34, 5.94 -154.23, 143.98 -136.31, 29.8 294.89, 85.73 -63.4, -28.12 in-in in 7.872 Saltbr-in 2.6248 HRD-in -80.23, -45.9 70.61, 1.75 in-in-out SNCiio in-out ActLoopNT-in 2.7501 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.56, 32.84 APE9-dihe-in -59.39, 139.65 APE8-dihe-in -81.36, 75.53 APE8-rot-na 28.93 APE67-dihe-in -77.55, -4.05 -62.31, -27.51 APE12-dist-na 10.9946 APE11-dist-na 12.667 APE10-dist-na 10.0695 APE9-dist-in 6.6324 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 B 302.0 281.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 4E4LD P23458 864 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.5361 13.748 ABAminus -114.27, -0.81 -153.61, 143.22 -135.12, 28.03 293.73, 85.38 -57.66, -27.04 in-in in 7.7412 Saltbr-in 2.5547 HRD-in -77.01, -53.08 75.86, 4.71 in-in-out SNCiio in-out ActLoopNT-in 2.8229 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.68, 33.68 APE9-dihe-in -65.48, 130.64 APE8-dihe-in -74.63, 79.76 APE8-rot-na 26.43 APE67-dihe-in -75.57, -2.67 -62.18, -32.34 APE12-dist-na 11.5127 APE11-dist-na 12.875 APE10-dist-na 10.4155 APE9-dist-in 6.7005 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 D 302.0 283.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1

PDB: 4E4L — TYR JAK1_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name