PDB: 4CXA — CMGC CDK12_HUMAN

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4CXAC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 4CXAA Q9NYV4 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.4362 15.0223 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.1775 Saltbr-in 2.5134 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.7933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.2123 APE11-dist-in 11.6623 APE10-dist-in 7.3626 APE9-dist-in 3.5055 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340.0 330.0 3 29 28 1 [[727, 1020]] 1.0 4cxa CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4CXAC Q9NYV4 718 1048 1490.0 No_ligand No_ligand Inactive DFGin 7.1995 15.2477 BLAminus -126.07, 177.23 58.72, 82.97 -102.36, 37.62 286.53, 69.22 -80.81, -13.97 in-none in 8.0455 Saltbr-none 999.0 HRD-in -86.15, -47.73 62.33, 17.56 none-in-out SNCnio in-out ActLoopNT-in 3.0475 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.86, 161.73 APE9-dihe-na 68.73, 142.31 APE8-dihe-in -55.95, 146.27 APE8-rot-out 63.52 APE67-dihe-in -66.87, -27.84 -54.72, -39.98 APE12-dist-in 13.1798 APE11-dist-in 11.907 APE10-dist-in 7.4808 APE9-dist-in 3.5773 None TPO893 TPO893 XRAY 3.15 0.224 0.279 C 340.0 331.0 0 29 29 0 [[727, 1020]] 1.0 4cxa CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 4CXA — CMGC CDK12_HUMAN

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4CXAC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 4CXAA Q9NYV4 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.4362 15.0223 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.1775 Saltbr-in 2.5134 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.7933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.2123 APE11-dist-in 11.6623 APE10-dist-in 7.3626 APE9-dist-in 3.5055 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340.0 330.0 3 29 28 1 [[727, 1020]] 1.0 4cxa Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4CXAC Q9NYV4 718 1048 1490.0 No_ligand No_ligand Inactive DFGin 7.1995 15.2477 BLAminus -126.07, 177.23 58.72, 82.97 -102.36, 37.62 286.53, 69.22 -80.81, -13.97 in-none in 8.0455 Saltbr-none 999.0 HRD-in -86.15, -47.73 62.33, 17.56 none-in-out SNCnio in-out ActLoopNT-in 3.0475 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.86, 161.73 APE9-dihe-na 68.73, 142.31 APE8-dihe-in -55.95, 146.27 APE8-rot-out 63.52 APE67-dihe-in -66.87, -27.84 -54.72, -39.98 APE12-dist-in 13.1798 APE11-dist-in 11.907 APE10-dist-in 7.4808 APE9-dist-in 3.5773 None TPO893 TPO893 XRAY 3.15 0.224 0.279 C 340.0 331.0 0 29 29 0 [[727, 1020]] 1.0 4cxa Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

PDB: 4CXA — CMGC CDK12_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name