PDB: 4AZE — CMGC DYR1A_HUMAN

Total number of chains: 3
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 4AZEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 4AZEA Q13627 132 481 763.0 3RA:700 Type1 Active DFGin 6.9533 14.6162 BLAminus -137.23, 169.92 67.49, 90.44 -106.39, 23.89 283.3, 71.95 -55.61, -37.62 in-in in 9.0098 Saltbr-in 2.8124 HRD-in -70.04, -49.18 72.92, 15.43 in-in-in SNCiii in-in ActLoopNT-in 2.8739 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.19, 169.65 APE9-dihe-na 74.45, 134.72 APE8-dihe-in -60.37, 136.79 APE8-rot-in 289.06 APE67-dihe-in -57.82, -32.3 -48.27, -49.81 APE12-dist-in 12.2654 APE11-dist-in 10.5618 APE10-dist-in 6.6352 APE9-dist-in 3.2564 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 A 382.0 350.0 0 25 25 0 [[159, 479]] 1.0 4aze CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4AZEB Q13627 135 481 763.0 3RA:700 Type1 Active DFGin 6.9238 14.6128 BLAminus -138.16, 169.5 68.4, 90.42 -106.1, 24.2 283.49, 72.02 -57.21, -35.99 in-in in 9.0221 Saltbr-in 2.9003 HRD-in -69.57, -48.1 73.99, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.8331 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.81, 169.0 APE9-dihe-na 74.6, 134.75 APE8-dihe-in -60.95, 138.61 APE8-rot-in 290.43 APE67-dihe-in -56.44, -36.37 -49.68, -48.78 APE12-dist-in 12.2764 APE11-dist-in 10.5588 APE10-dist-in 6.6312 APE9-dist-in 3.2256 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 B 382.0 347.0 0 25 25 0 [[159, 479]] 1.0 4aze CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4AZEC Q13627 132 481 763.0 3RA:700 Type1 Active DFGin 6.9331 14.6073 BLAminus -136.67, 171.08 67.02, 92.32 -107.7, 25.06 283.25, 71.9 -57.45, -37.58 in-in in 9.0017 Saltbr-in 2.8354 HRD-in -68.51, -50.21 73.5, 15.7 in-in-in SNCiii in-in ActLoopNT-in 2.8424 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.49, 169.71 APE9-dihe-na 73.57, 134.86 APE8-dihe-in -60.52, 139.24 APE8-rot-in 289.26 APE67-dihe-in -57.24, -34.82 -50.4, -48.08 APE12-dist-in 12.3165 APE11-dist-in 10.5695 APE10-dist-in 6.591 APE9-dist-in 3.2797 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 C 382.0 350.0 0 25 25 0 [[159, 479]] 1.0 4aze CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 4AZE — CMGC DYR1A_HUMAN

Total number of chains: 3
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 4AZEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 4AZEA Q13627 132 481 763.0 3RA:700 Type1 Active DFGin 6.9533 14.6162 BLAminus -137.23, 169.92 67.49, 90.44 -106.39, 23.89 283.3, 71.95 -55.61, -37.62 in-in in 9.0098 Saltbr-in 2.8124 HRD-in -70.04, -49.18 72.92, 15.43 in-in-in SNCiii in-in ActLoopNT-in 2.8739 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.19, 169.65 APE9-dihe-na 74.45, 134.72 APE8-dihe-in -60.37, 136.79 APE8-rot-in 289.06 APE67-dihe-in -57.82, -32.3 -48.27, -49.81 APE12-dist-in 12.2654 APE11-dist-in 10.5618 APE10-dist-in 6.6352 APE9-dist-in 3.2564 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 A 382.0 350.0 0 25 25 0 [[159, 479]] 1.0 4aze Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4AZEB Q13627 135 481 763.0 3RA:700 Type1 Active DFGin 6.9238 14.6128 BLAminus -138.16, 169.5 68.4, 90.42 -106.1, 24.2 283.49, 72.02 -57.21, -35.99 in-in in 9.0221 Saltbr-in 2.9003 HRD-in -69.57, -48.1 73.99, 12.32 in-in-in SNCiii in-in ActLoopNT-in 2.8331 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.81, 169.0 APE9-dihe-na 74.6, 134.75 APE8-dihe-in -60.95, 138.61 APE8-rot-in 290.43 APE67-dihe-in -56.44, -36.37 -49.68, -48.78 APE12-dist-in 12.2764 APE11-dist-in 10.5588 APE10-dist-in 6.6312 APE9-dist-in 3.2256 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 B 382.0 347.0 0 25 25 0 [[159, 479]] 1.0 4aze Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 4AZEC Q13627 132 481 763.0 3RA:700 Type1 Active DFGin 6.9331 14.6073 BLAminus -136.67, 171.08 67.02, 92.32 -107.7, 25.06 283.25, 71.9 -57.45, -37.58 in-in in 9.0017 Saltbr-in 2.8354 HRD-in -68.51, -50.21 73.5, 15.7 in-in-in SNCiii in-in ActLoopNT-in 2.8424 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.49, 169.71 APE9-dihe-na 73.57, 134.86 APE8-dihe-in -60.52, 139.24 APE8-rot-in 289.26 APE67-dihe-in -57.24, -34.82 -50.4, -48.08 APE12-dist-in 12.3165 APE11-dist-in 10.5695 APE10-dist-in 6.591 APE9-dist-in 3.2797 None SEP301,PTR321 SEP301,PTR321 XRAY 3.15 0.219 0.248 C 382.0 350.0 0 25 25 0 [[159, 479]] 1.0 4aze Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 4AZE — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name