| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BC | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.6986 | 13.7547 | BLAminus | -145.08, 171.25 | 61.11, 107.16 | -112.51, 31.96 | 284.23, 68.66 | -61.45, -37.77 | in-in | in | 8.9354 | Saltbr-in | 2.7569 | HRD-in | -69.97, -44.39 | 78.89, -25.31 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0637 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -86.67, -20.62 | 999.0, 173.38 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | C | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BD | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.7112 | 13.9064 | BLAminus | -145.79, 167.53 | 68.59, 102.7 | -108.4, 30.91 | 282.62, 68.72 | -66.3, -36.77 | in-in | in | 8.9833 | Saltbr-in | 3.4075 | HRD-in | -69.48, -46.19 | 68.3, 18.38 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.2897 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -107.53, -10.82 | 999.0, -167.45 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | D | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BE | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.837 | 13.7658 | BLAminus | -139.59, 169.54 | 69.21, 97.38 | -104.17, 34.32 | 282.85, 67.94 | -62.67, -38.94 | in-in | in | 8.985 | Saltbr-in | 2.6791 | HRD-in | -71.5, -45.64 | 70.77, 10.18 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0924 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -99.43, -1.37 | 999.0, -172.24 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | E | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BF | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.6213 | 13.6878 | BLAminus | -142.07, 170.01 | 64.83, 98.1 | -101.81, 30.72 | 282.18, 71.32 | -65.73, -35.15 | in-in | in | 8.992 | Saltbr-in | 2.7023 | HRD-in | -80.67, -40.94 | 69.92, -1.27 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0318 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -101.55, -20.21 | 999.0, -176.26 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | F | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BG | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.7144 | 14.0107 | BLAminus | -137.77, 173.07 | 72.09, 96.81 | -108.03, 29.22 | 281.02, 70.25 | -63.92, -39.04 | in-in | in | 9.1 | Saltbr-in | 2.6573 | HRD-in | -83.07, -38.78 | 69.53, -15.76 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.9975 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -92.27, -2.06 | 999.0, -177.05 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | G | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BH | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.7828 | 13.684 | BLAminus | -141.56, 171.1 | 67.42, 98.81 | -106.45, 32.94 | 281.72, 69.09 | -63.41, -39.6 | in-in | in | 8.8096 | Saltbr-in | 2.6383 | HRD-in | -69.99, -38.96 | 66.77, 4.24 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0713 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -98.5, -19.42 | 999.0, -171.21 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | H | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BI | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.8317 | 13.6152 | BLAminus | -144.83, 172.47 | 66.99, 98.69 | -105.77, 31.32 | 281.48, 70.34 | -64.97, -40.42 | in-none | in | 8.9024 | Saltbr-none | 999.0 | HRD-in | -71.72, -44.4 | 66.46, 8.73 | none-in-none | SNCnin | in-none | ActLoopNT-in | 2.9916 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -89.48, -16.84 | 999.0, -178.73 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | I | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BJ | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.5851 | 13.7263 | BLAminus | -139.73, 172.93 | 64.33, 98.73 | -104.15, 24.81 | 279.87, 69.77 | -58.59, -39.13 | in-in | in | 8.8294 | Saltbr-in | 2.7422 | HRD-in | -76.49, -44.95 | 70.08, 8.99 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0057 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -95.9, -9.71 | 999.0, -177.57 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | J | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BK | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.6485 | 13.8862 | BLAminus | -142.88, 173.31 | 64.15, 96.21 | -100.21, 30.51 | 279.28, 69.33 | -63.22, -35.24 | in-in | in | 8.9511 | Saltbr-in | 2.6448 | HRD-in | -75.63, -40.1 | 74.89, -28.49 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0549 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -102.3, -6.38 | 999.0, -170.81 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | K | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BL | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.7541 | 13.8106 | BLAminus | -149.62, 172.88 | 62.04, 95.8 | -100.2, 29.15 | 282.37, 69.48 | -62.27, -33.8 | in-in | in | 8.8089 | Saltbr-in | 2.5402 | HRD-in | -71.4, -42.73 | 71.32, 3.36 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0859 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -93.48, -10.45 | 999.0, 179.38 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | L | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BA | P49137 | 47 | 345 | 400.0 | 05B:1000 | Type1 | None | DFGin | 4.7931 | 14.0393 | BLAminus | -133.6, 172.77 | 62.95, 100.31 | -104.2, 34.41 | 278.04, 66.12 | -71.39, -34.54 | in-in | in | 9.0076 | Saltbr-in | 2.4091 | HRD-in | -83.09, -47.43 | 74.93, -6.02 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.1117 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -85.52, -24.55 | 999.0, -179.19 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | A | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BB | P49137 | 47 | 345 | 400.0 | 05B:1000 | Type1 | None | DFGin | 4.5398 | 13.8451 | BLAminus | -142.13, 174.13 | 65.41, 93.56 | -99.51, 29.64 | 280.69, 67.08 | -63.86, -41.52 | in-in | in | 9.1018 | Saltbr-in | 2.5931 | HRD-in | -69.44, -43.13 | 63.83, 12.28 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.017 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -97.51, -10.75 | 999.0, -173.14 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | B | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BC | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.6986 | 13.7547 | BLAminus | -145.08, 171.25 | 61.11, 107.16 | -112.51, 31.96 | 284.23, 68.66 | -61.45, -37.77 | in-in | in | 8.9354 | Saltbr-in | 2.7569 | HRD-in | -69.97, -44.39 | 78.89, -25.31 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0637 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -86.67, -20.62 | 999.0, 173.38 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | C | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BD | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.7112 | 13.9064 | BLAminus | -145.79, 167.53 | 68.59, 102.7 | -108.4, 30.91 | 282.62, 68.72 | -66.3, -36.77 | in-in | in | 8.9833 | Saltbr-in | 3.4075 | HRD-in | -69.48, -46.19 | 68.3, 18.38 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.2897 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -107.53, -10.82 | 999.0, -167.45 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | D | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BE | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.837 | 13.7658 | BLAminus | -139.59, 169.54 | 69.21, 97.38 | -104.17, 34.32 | 282.85, 67.94 | -62.67, -38.94 | in-in | in | 8.985 | Saltbr-in | 2.6791 | HRD-in | -71.5, -45.64 | 70.77, 10.18 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0924 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -99.43, -1.37 | 999.0, -172.24 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | E | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BF | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.6213 | 13.6878 | BLAminus | -142.07, 170.01 | 64.83, 98.1 | -101.81, 30.72 | 282.18, 71.32 | -65.73, -35.15 | in-in | in | 8.992 | Saltbr-in | 2.7023 | HRD-in | -80.67, -40.94 | 69.92, -1.27 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0318 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -101.55, -20.21 | 999.0, -176.26 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | F | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BG | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.7144 | 14.0107 | BLAminus | -137.77, 173.07 | 72.09, 96.81 | -108.03, 29.22 | 281.02, 70.25 | -63.92, -39.04 | in-in | in | 9.1 | Saltbr-in | 2.6573 | HRD-in | -83.07, -38.78 | 69.53, -15.76 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.9975 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -92.27, -2.06 | 999.0, -177.05 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | G | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BH | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.7828 | 13.684 | BLAminus | -141.56, 171.1 | 67.42, 98.81 | -106.45, 32.94 | 281.72, 69.09 | -63.41, -39.6 | in-in | in | 8.8096 | Saltbr-in | 2.6383 | HRD-in | -69.99, -38.96 | 66.77, 4.24 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0713 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -98.5, -19.42 | 999.0, -171.21 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | H | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BI | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.8317 | 13.6152 | BLAminus | -144.83, 172.47 | 66.99, 98.69 | -105.77, 31.32 | 281.48, 70.34 | -64.97, -40.42 | in-none | in | 8.9024 | Saltbr-none | 999.0 | HRD-in | -71.72, -44.4 | 66.46, 8.73 | none-in-none | SNCnin | in-none | ActLoopNT-in | 2.9916 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -89.48, -16.84 | 999.0, -178.73 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | I | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BJ | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.5851 | 13.7263 | BLAminus | -139.73, 172.93 | 64.33, 98.73 | -104.15, 24.81 | 279.87, 69.77 | -58.59, -39.13 | in-in | in | 8.8294 | Saltbr-in | 2.7422 | HRD-in | -76.49, -44.95 | 70.08, 8.99 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0057 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -95.9, -9.71 | 999.0, -177.57 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | J | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BK | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.6485 | 13.8862 | BLAminus | -142.88, 173.31 | 64.15, 96.21 | -100.21, 30.51 | 279.28, 69.33 | -63.22, -35.24 | in-in | in | 8.9511 | Saltbr-in | 2.6448 | HRD-in | -75.63, -40.1 | 74.89, -28.49 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0549 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -102.3, -6.38 | 999.0, -170.81 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | K | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BL | P49137 | 47 | 345 | 400.0 | No_ligand | No_ligand | None | DFGin | 4.7541 | 13.8106 | BLAminus | -149.62, 172.88 | 62.04, 95.8 | -100.2, 29.15 | 282.37, 69.48 | -62.27, -33.8 | in-in | in | 8.8089 | Saltbr-in | 2.5402 | HRD-in | -71.4, -42.73 | 71.32, 3.36 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.0859 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -93.48, -10.45 | 999.0, 179.38 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | L | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BA | P49137 | 47 | 345 | 400.0 | 05B:1000 | Type1 | None | DFGin | 4.7931 | 14.0393 | BLAminus | -133.6, 172.77 | 62.95, 100.31 | -104.2, 34.41 | 278.04, 66.12 | -71.39, -34.54 | in-in | in | 9.0076 | Saltbr-in | 2.4091 | HRD-in | -83.09, -47.43 | 74.93, -6.02 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.1117 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -85.52, -24.55 | 999.0, -179.19 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | A | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| CAMK | MAPKAPK2 | MAPK2_HUMAN | 3R2BB | P49137 | 47 | 345 | 400.0 | 05B:1000 | Type1 | None | DFGin | 4.5398 | 13.8451 | BLAminus | -142.13, 174.13 | 65.41, 93.56 | -99.51, 29.64 | 280.69, 67.08 | -63.86, -41.52 | in-in | in | 9.1018 | Saltbr-in | 2.5931 | HRD-in | -69.44, -43.13 | 63.83, 12.28 | in-in-none | SNCiin | in-none | ActLoopNT-in | 3.017 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | -97.51, -10.75 | 999.0, -173.14 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.9 | 0.279 | 0.316 | B | 318.0 | 272.0 | 27 | 27 | 16 | 11 | [[63, 325]] | 1.0 | 3r2b | Homo sapiens | CAMK_MAPKAPK2_HUMAN | CAMK | 3.2e-80 | 275.1 | 3.0 | 256.0 | 254.0 | 206 | 207 | 208 | 210 | 212 | 93 | 104 | 108 | 183 | 185 | 184 | 186.0 | 245 | 233 | 228 | 227 | 226 | 225 | 224 | 223 | 222 | 139 | MAP kinase-activated protein kinase 2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|