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| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | IGF1R | IGF1R_HUMAN | 3F5PA | P08069 | 981 | 1286 | 1367.0 | 741:60001 | Type1.5_Front | Inactive | DFGin | 6.61 | 16.748 | ABAminus | -138.06, -25.59 | -129.58, 107.73 | -116.06, 43.16 | 310.54, 93.03 | -78.83, -11.08 | out-out | out | 11.275 | Saltbr-out | 6.906 | HRD-in | -67.38, -43.83 | 73.05, -28.09 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.971 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -109.2, 9.43 | APE9-dihe-in | -62.84, 138.01 | APE8-dihe-in | -63.08, 132.26 | APE8-rot-na | 338.19 | APE67-dihe-in | -72.6, -14.18 | -69.93, -24.15 | APE12-dist-na | 13.896 | APE11-dist-na | 10.264 | APE10-dist-na | 9.82 | APE9-dist-in | 6.264 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | A | 308 | 301 | 5 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PB | P08069 | 981 | 1286 | 1367.0 | 741:60002 | Type1.5_Front | Inactive | DFGin | 6.74 | 16.774 | ABAminus | -147.75, -6.76 | -126.37, 106.72 | -113.94, 18.15 | 303.38, 100.96 | -63.88, -6.59 | out-out | out | 11.005 | Saltbr-out | 7.016 | HRD-in | -75.04, -39.09 | 66.41, -28.14 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.98 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -109.44, 30.24 | APE9-dihe-in | -71.55, 137.53 | APE8-dihe-in | -59.54, 131.44 | APE8-rot-na | 338.8 | APE67-dihe-in | -62.32, -22.71 | -80.06, -23.54 | APE12-dist-na | 13.869 | APE11-dist-na | 10.125 | APE10-dist-na | 10.151 | APE9-dist-in | 6.368 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | B | 308 | 300 | 6 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PC | P08069 | 981 | 1286 | 1367.0 | 741:60003 | Type1.5_Front | Inactive | DFGin | 6.476 | 16.508 | ABAminus | -131.28, -29.71 | -123.17, 122.2 | -124.32, 31.59 | 310.58, 97.96 | -71.28, -4.47 | out-out | out | 11.326 | Saltbr-out | 7.151 | HRD-in | -67.89, -44.01 | 69.59, -29.8 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.929 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -113.67, 21.52 | APE9-dihe-in | -66.68, 135.08 | APE8-dihe-in | -55.37, 125.9 | APE8-rot-na | 335.16 | APE67-dihe-in | -63.64, -20.63 | -71.03, -23.62 | APE12-dist-na | 13.947 | APE11-dist-na | 10.314 | APE10-dist-na | 10.017 | APE9-dist-in | 6.347 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | C | 308 | 303 | 3 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PD | P08069 | 981 | 1286 | 1367.0 | 741:60004 | Type1.5_Front | Inactive | DFGin | 6.691 | 16.948 | ABAminus | -123.55, -41.41 | -120.41, 118.96 | -120.72, 27.37 | 304.28, 99.29 | -67.93, -13.37 | out-out | out | 11.466 | Saltbr-out | 7.444 | HRD-in | -72.44, -43.38 | 70.69, -28.87 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.922 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -114.64, 11.87 | APE9-dihe-in | -60.75, 136.9 | APE8-dihe-in | -61.78, 130.42 | APE8-rot-na | 20.36 | APE67-dihe-in | -67.44, -13.84 | -72.23, -24.66 | APE12-dist-na | 13.872 | APE11-dist-na | 10.33 | APE10-dist-na | 10.049 | APE9-dist-in | 6.368 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | D | 308 | 299 | 7 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PE | P08069 | 981 | 1285 | 1367.0 | 741:60005 | Type1.5_Front | Inactive | DFGin | 6.694 | 16.82 | ABAminus | -135.52, -29.09 | -118.77, 122.15 | -123.6, 9.7 | 296.44, 108.3 | -57.57, -18.08 | out-out | out | 11.069 | Saltbr-out | 7.271 | HRD-in | -68.6, -42.13 | 69.21, -24.51 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.855 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -119.4, 7.14 | APE9-dihe-in | -54.67, 137.93 | APE8-dihe-in | -65.35, 131.07 | APE8-rot-na | 341.16 | APE67-dihe-in | -64.5, -10.68 | -68.92, -32.58 | APE12-dist-na | 14.021 | APE11-dist-na | 10.452 | APE10-dist-na | 10.148 | APE9-dist-in | 6.28 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | E | 308 | 301 | 4 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PF | P08069 | 981 | 1285 | 1367.0 | 741:60006 | Type1.5_Front | Inactive | DFGin | 6.483 | 16.672 | ABAminus | -133.64, -29.08 | -124.95, 116.76 | -119.73, 22.12 | 307.37, 101.54 | -62.11, -21.12 | out-out | out | 11.456 | Saltbr-out | 7.439 | HRD-in | -66.51, -41.75 | 69.88, -16.79 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.973 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -109.91, 14.58 | APE9-dihe-in | -64.37, 136.64 | APE8-dihe-in | -51.49, 126.07 | APE8-rot-na | 332.53 | APE67-dihe-in | -71.57, -11.29 | -75.66, -21.34 | APE12-dist-na | 14.067 | APE11-dist-na | 10.393 | APE10-dist-na | 10.014 | APE9-dist-in | 6.14 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | F | 308 | 301 | 4 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PG | P08069 | 981 | 1285 | 1367.0 | 741:60007 | Type1.5_Front | Inactive | DFGin | 6.83 | 16.816 | ABAminus | -142.79, -22.58 | -124.37, 117.71 | -119.99, 31.05 | 299.76, 104.87 | -73.83, -11.77 | out-out | out | 11.313 | Saltbr-out | 7.0 | HRD-in | -78.88, -44.79 | 72.24, -24.62 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.969 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -107.94, 24.79 | APE9-dihe-in | -73.02, 139.57 | APE8-dihe-in | -63.97, 132.91 | APE8-rot-na | 337.39 | APE67-dihe-in | -71.97, -5.77 | -75.29, -20.42 | APE12-dist-na | 14.012 | APE11-dist-na | 10.239 | APE10-dist-na | 9.892 | APE9-dist-in | 6.221 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | G | 308 | 301 | 4 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PH | P08069 | 981 | 1286 | 1367.0 | 741:60008 | Type1.5_Front | Inactive | DFGin | 6.629 | 16.429 | ABAminus | -135.18, -37.61 | -123.09, 112.94 | -114.78, 16.78 | 310.03, 93.21 | -57.54, -9.93 | out-out | out | 11.26 | Saltbr-out | 7.542 | HRD-in | -79.51, -41.44 | 75.33, -29.75 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.981 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -108.47, 10.93 | APE9-dihe-in | -59.95, 134.42 | APE8-dihe-in | -57.02, 119.96 | APE8-rot-na | 332.96 | APE67-dihe-in | -72.4, -8.79 | -61.06, -25.16 | APE12-dist-na | 14.198 | APE11-dist-na | 10.466 | APE10-dist-na | 10.185 | APE9-dist-in | 6.401 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | H | 308 | 301 | 5 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PI | P08069 | 981 | 1285 | 1367.0 | 741:60009 | Type1.5_Front | Inactive | DFGin | 6.637 | 16.461 | ABAminus | -144.33, -12.52 | -125.22, 113.79 | -116.99, 15.78 | 300.54, 108.07 | -62.21, -14.24 | out-out | out | 10.889 | Saltbr-out | 6.889 | HRD-in | -60.61, -42.68 | 67.93, -23.46 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.917 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -109.73, 15.28 | APE9-dihe-in | -67.33, 139.53 | APE8-dihe-in | -63.65, 128.86 | APE8-rot-na | 345.01 | APE67-dihe-in | -68.57, -17.49 | -69.06, -21.27 | APE12-dist-na | 13.914 | APE11-dist-na | 10.23 | APE10-dist-na | 9.797 | APE9-dist-in | 6.228 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | I | 308 | 296 | 9 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PJ | P08069 | 981 | 1285 | 1367.0 | 741:60010 | Type1.5_Front | Inactive | DFGin | 6.647 | 16.713 | ABAminus | -137.35, -22.07 | -131.76, 119.09 | -115.56, 22.57 | 300.22, 101.26 | -61.94, -18.78 | out-out | out | 10.94 | Saltbr-out | 6.672 | HRD-in | -74.88, -41.95 | 72.95, -30.32 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.964 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -114.55, 26.2 | APE9-dihe-in | -76.04, 131.14 | APE8-dihe-in | -47.14, 118.18 | APE8-rot-na | 11.41 | APE67-dihe-in | -74.24, -9.54 | -60.76, -20.49 | APE12-dist-na | 14.276 | APE11-dist-na | 10.237 | APE10-dist-na | 10.205 | APE9-dist-in | 6.46 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | J | 308 | 295 | 10 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PK | P08069 | 981 | 1285 | 1367.0 | 741:60011 | Type1.5_Front | Inactive | DFGin | 6.407 | 16.547 | ABAminus | -137.37, -28.84 | -124.99, 120.18 | -119.7, 16.02 | 301.42, 102.62 | -59.26, -20.51 | out-out | out | 11.163 | Saltbr-out | 6.697 | HRD-in | -69.13, -50.03 | 76.13, -25.52 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.956 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -116.66, 8.96 | APE9-dihe-in | -58.52, 142.15 | APE8-dihe-in | -59.15, 129.43 | APE8-rot-na | 338.61 | APE67-dihe-in | -60.69, -25.24 | -69.7, -27.83 | APE12-dist-na | 14.114 | APE11-dist-na | 10.152 | APE10-dist-na | 9.947 | APE9-dist-in | 6.405 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | K | 308 | 295 | 10 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PL | P08069 | 981 | 1285 | 1367.0 | 741:60013 | Type1.5_Front | Inactive | DFGin | 6.56 | 16.394 | ABAminus | -130.09, -30.53 | -132.5, 115.28 | -114.91, 24.81 | 310.05, 96.63 | -62.07, -19.46 | out-out | out | 11.029 | Saltbr-out | 6.97 | HRD-in | -66.51, -50.25 | 76.73, -28.84 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.868 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -112.68, 19.75 | APE9-dihe-in | -67.29, 128.45 | APE8-dihe-in | -49.93, 126.32 | APE8-rot-na | 13.1 | APE67-dihe-in | -68.28, -21.28 | -70.5, -21.67 | APE12-dist-na | 14.19 | APE11-dist-na | 10.315 | APE10-dist-na | 10.171 | APE9-dist-in | 6.356 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | L | 308 | 295 | 10 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PM | P08069 | 981 | 1285 | 1367.0 | 741:60012 | Type1.5_Front | Inactive | DFGin | 6.771 | 16.613 | ABAminus | -128.57, -42.47 | -122.66, 116.51 | -120.09, 38.47 | 314.34, 94.44 | -73.17, -23.07 | out-out | out | 11.214 | Saltbr-out | 7.332 | HRD-in | -78.25, -49.69 | 75.71, -26.22 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.877 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -117.51, 9.39 | APE9-dihe-in | -60.52, 138.49 | APE8-dihe-in | -61.63, 125.4 | APE8-rot-na | 341.15 | APE67-dihe-in | -68.1, -5.47 | -67.37, -25.72 | APE12-dist-na | 13.872 | APE11-dist-na | 10.161 | APE10-dist-na | 9.914 | APE9-dist-in | 6.394 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | M | 308 | 297 | 8 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PR | P08069 | 981 | 1285 | 1367.0 | 741:60014 | Type1.5_Front | Inactive | DFGin | 6.538 | 16.629 | ABAminus | -139.04, -20.87 | -125.55, 103.39 | -109.5, 25.04 | 311.13, 96.42 | -58.59, -20.19 | out-out | out | 11.106 | Saltbr-out | 7.253 | HRD-in | -61.08, -46.93 | 71.37, -30.05 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.994 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -121.06, 13.96 | APE9-dihe-in | -63.18, 134.5 | APE8-dihe-in | -57.6, 125.54 | APE8-rot-na | 338.75 | APE67-dihe-in | -68.47, -18.65 | -66.66, -22.95 | APE12-dist-na | 14.134 | APE11-dist-na | 10.186 | APE10-dist-na | 10.002 | APE9-dist-in | 6.439 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | R | 308 | 296 | 9 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PS | P08069 | 981 | 1286 | 1367.0 | 741:60015 | Type1.5_Front | Inactive | DFGin | 6.621 | 16.362 | ABAminus | -137.74, -25.34 | -122.78, 115.95 | -115.05, 8.88 | 304.38, 111.51 | -47.71, -27.84 | out-out | out | 11.103 | Saltbr-out | 6.886 | HRD-in | -69.09, -43.99 | 64.64, -15.6 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.902 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -120.58, 17.02 | APE9-dihe-in | -62.27, 136.85 | APE8-dihe-in | -61.63, 122.69 | APE8-rot-na | 21.86 | APE67-dihe-in | -66.47, -21.61 | -67.46, -19.45 | APE12-dist-na | 13.986 | APE11-dist-na | 10.237 | APE10-dist-na | 10.157 | APE9-dist-in | 6.245 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | S | 308 | 297 | 9 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PT | P08069 | 981 | 1286 | 1367.0 | 741:60016 | Type1.5_Front | Inactive | DFGin | 6.52 | 16.375 | ABAminus | -141.26, -19.49 | -137.77, 101.2 | -103.13, 11.95 | 304.34, 96.76 | -50.98, -21.44 | out-out | out | 10.787 | Saltbr-out | 6.707 | HRD-in | -77.18, -39.29 | 69.12, -25.78 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.859 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -114.42, 13.71 | APE9-dihe-in | -68.71, 130.72 | APE8-dihe-in | -54.94, 124.12 | APE8-rot-na | 340.88 | APE67-dihe-in | -66.19, -17.17 | -61.43, -26.74 | APE12-dist-na | 13.846 | APE11-dist-na | 10.239 | APE10-dist-na | 9.88 | APE9-dist-in | 6.273 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | T | 308 | 297 | 9 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | IGF1R | IGF1R_HUMAN | 3F5PA | P08069 | 981 | 1286 | 1367.0 | 741:60001 | Type1.5_Front | Inactive | DFGin | 6.61 | 16.748 | ABAminus | -138.06, -25.59 | -129.58, 107.73 | -116.06, 43.16 | 310.54, 93.03 | -78.83, -11.08 | out-out | out | 11.275 | Saltbr-out | 6.906 | HRD-in | -67.38, -43.83 | 73.05, -28.09 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.971 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -109.2, 9.43 | APE9-dihe-in | -62.84, 138.01 | APE8-dihe-in | -63.08, 132.26 | APE8-rot-na | 338.19 | APE67-dihe-in | -72.6, -14.18 | -69.93, -24.15 | APE12-dist-na | 13.896 | APE11-dist-na | 10.264 | APE10-dist-na | 9.82 | APE9-dist-in | 6.264 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | A | 308 | 301 | 5 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PB | P08069 | 981 | 1286 | 1367.0 | 741:60002 | Type1.5_Front | Inactive | DFGin | 6.74 | 16.774 | ABAminus | -147.75, -6.76 | -126.37, 106.72 | -113.94, 18.15 | 303.38, 100.96 | -63.88, -6.59 | out-out | out | 11.005 | Saltbr-out | 7.016 | HRD-in | -75.04, -39.09 | 66.41, -28.14 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.98 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -109.44, 30.24 | APE9-dihe-in | -71.55, 137.53 | APE8-dihe-in | -59.54, 131.44 | APE8-rot-na | 338.8 | APE67-dihe-in | -62.32, -22.71 | -80.06, -23.54 | APE12-dist-na | 13.869 | APE11-dist-na | 10.125 | APE10-dist-na | 10.151 | APE9-dist-in | 6.368 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | B | 308 | 300 | 6 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PC | P08069 | 981 | 1286 | 1367.0 | 741:60003 | Type1.5_Front | Inactive | DFGin | 6.476 | 16.508 | ABAminus | -131.28, -29.71 | -123.17, 122.2 | -124.32, 31.59 | 310.58, 97.96 | -71.28, -4.47 | out-out | out | 11.326 | Saltbr-out | 7.151 | HRD-in | -67.89, -44.01 | 69.59, -29.8 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.929 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -113.67, 21.52 | APE9-dihe-in | -66.68, 135.08 | APE8-dihe-in | -55.37, 125.9 | APE8-rot-na | 335.16 | APE67-dihe-in | -63.64, -20.63 | -71.03, -23.62 | APE12-dist-na | 13.947 | APE11-dist-na | 10.314 | APE10-dist-na | 10.017 | APE9-dist-in | 6.347 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | C | 308 | 303 | 3 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PD | P08069 | 981 | 1286 | 1367.0 | 741:60004 | Type1.5_Front | Inactive | DFGin | 6.691 | 16.948 | ABAminus | -123.55, -41.41 | -120.41, 118.96 | -120.72, 27.37 | 304.28, 99.29 | -67.93, -13.37 | out-out | out | 11.466 | Saltbr-out | 7.444 | HRD-in | -72.44, -43.38 | 70.69, -28.87 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.922 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -114.64, 11.87 | APE9-dihe-in | -60.75, 136.9 | APE8-dihe-in | -61.78, 130.42 | APE8-rot-na | 20.36 | APE67-dihe-in | -67.44, -13.84 | -72.23, -24.66 | APE12-dist-na | 13.872 | APE11-dist-na | 10.33 | APE10-dist-na | 10.049 | APE9-dist-in | 6.368 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | D | 308 | 299 | 7 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PE | P08069 | 981 | 1285 | 1367.0 | 741:60005 | Type1.5_Front | Inactive | DFGin | 6.694 | 16.82 | ABAminus | -135.52, -29.09 | -118.77, 122.15 | -123.6, 9.7 | 296.44, 108.3 | -57.57, -18.08 | out-out | out | 11.069 | Saltbr-out | 7.271 | HRD-in | -68.6, -42.13 | 69.21, -24.51 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.855 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -119.4, 7.14 | APE9-dihe-in | -54.67, 137.93 | APE8-dihe-in | -65.35, 131.07 | APE8-rot-na | 341.16 | APE67-dihe-in | -64.5, -10.68 | -68.92, -32.58 | APE12-dist-na | 14.021 | APE11-dist-na | 10.452 | APE10-dist-na | 10.148 | APE9-dist-in | 6.28 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | E | 308 | 301 | 4 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PF | P08069 | 981 | 1285 | 1367.0 | 741:60006 | Type1.5_Front | Inactive | DFGin | 6.483 | 16.672 | ABAminus | -133.64, -29.08 | -124.95, 116.76 | -119.73, 22.12 | 307.37, 101.54 | -62.11, -21.12 | out-out | out | 11.456 | Saltbr-out | 7.439 | HRD-in | -66.51, -41.75 | 69.88, -16.79 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.973 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -109.91, 14.58 | APE9-dihe-in | -64.37, 136.64 | APE8-dihe-in | -51.49, 126.07 | APE8-rot-na | 332.53 | APE67-dihe-in | -71.57, -11.29 | -75.66, -21.34 | APE12-dist-na | 14.067 | APE11-dist-na | 10.393 | APE10-dist-na | 10.014 | APE9-dist-in | 6.14 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | F | 308 | 301 | 4 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PG | P08069 | 981 | 1285 | 1367.0 | 741:60007 | Type1.5_Front | Inactive | DFGin | 6.83 | 16.816 | ABAminus | -142.79, -22.58 | -124.37, 117.71 | -119.99, 31.05 | 299.76, 104.87 | -73.83, -11.77 | out-out | out | 11.313 | Saltbr-out | 7.0 | HRD-in | -78.88, -44.79 | 72.24, -24.62 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.969 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -107.94, 24.79 | APE9-dihe-in | -73.02, 139.57 | APE8-dihe-in | -63.97, 132.91 | APE8-rot-na | 337.39 | APE67-dihe-in | -71.97, -5.77 | -75.29, -20.42 | APE12-dist-na | 14.012 | APE11-dist-na | 10.239 | APE10-dist-na | 9.892 | APE9-dist-in | 6.221 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | G | 308 | 301 | 4 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PH | P08069 | 981 | 1286 | 1367.0 | 741:60008 | Type1.5_Front | Inactive | DFGin | 6.629 | 16.429 | ABAminus | -135.18, -37.61 | -123.09, 112.94 | -114.78, 16.78 | 310.03, 93.21 | -57.54, -9.93 | out-out | out | 11.26 | Saltbr-out | 7.542 | HRD-in | -79.51, -41.44 | 75.33, -29.75 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.981 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -108.47, 10.93 | APE9-dihe-in | -59.95, 134.42 | APE8-dihe-in | -57.02, 119.96 | APE8-rot-na | 332.96 | APE67-dihe-in | -72.4, -8.79 | -61.06, -25.16 | APE12-dist-na | 14.198 | APE11-dist-na | 10.466 | APE10-dist-na | 10.185 | APE9-dist-in | 6.401 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | H | 308 | 301 | 5 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PI | P08069 | 981 | 1285 | 1367.0 | 741:60009 | Type1.5_Front | Inactive | DFGin | 6.637 | 16.461 | ABAminus | -144.33, -12.52 | -125.22, 113.79 | -116.99, 15.78 | 300.54, 108.07 | -62.21, -14.24 | out-out | out | 10.889 | Saltbr-out | 6.889 | HRD-in | -60.61, -42.68 | 67.93, -23.46 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.917 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -109.73, 15.28 | APE9-dihe-in | -67.33, 139.53 | APE8-dihe-in | -63.65, 128.86 | APE8-rot-na | 345.01 | APE67-dihe-in | -68.57, -17.49 | -69.06, -21.27 | APE12-dist-na | 13.914 | APE11-dist-na | 10.23 | APE10-dist-na | 9.797 | APE9-dist-in | 6.228 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | I | 308 | 296 | 9 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PJ | P08069 | 981 | 1285 | 1367.0 | 741:60010 | Type1.5_Front | Inactive | DFGin | 6.647 | 16.713 | ABAminus | -137.35, -22.07 | -131.76, 119.09 | -115.56, 22.57 | 300.22, 101.26 | -61.94, -18.78 | out-out | out | 10.94 | Saltbr-out | 6.672 | HRD-in | -74.88, -41.95 | 72.95, -30.32 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.964 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -114.55, 26.2 | APE9-dihe-in | -76.04, 131.14 | APE8-dihe-in | -47.14, 118.18 | APE8-rot-na | 11.41 | APE67-dihe-in | -74.24, -9.54 | -60.76, -20.49 | APE12-dist-na | 14.276 | APE11-dist-na | 10.237 | APE10-dist-na | 10.205 | APE9-dist-in | 6.46 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | J | 308 | 295 | 10 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PK | P08069 | 981 | 1285 | 1367.0 | 741:60011 | Type1.5_Front | Inactive | DFGin | 6.407 | 16.547 | ABAminus | -137.37, -28.84 | -124.99, 120.18 | -119.7, 16.02 | 301.42, 102.62 | -59.26, -20.51 | out-out | out | 11.163 | Saltbr-out | 6.697 | HRD-in | -69.13, -50.03 | 76.13, -25.52 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.956 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -116.66, 8.96 | APE9-dihe-in | -58.52, 142.15 | APE8-dihe-in | -59.15, 129.43 | APE8-rot-na | 338.61 | APE67-dihe-in | -60.69, -25.24 | -69.7, -27.83 | APE12-dist-na | 14.114 | APE11-dist-na | 10.152 | APE10-dist-na | 9.947 | APE9-dist-in | 6.405 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | K | 308 | 295 | 10 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PL | P08069 | 981 | 1285 | 1367.0 | 741:60013 | Type1.5_Front | Inactive | DFGin | 6.56 | 16.394 | ABAminus | -130.09, -30.53 | -132.5, 115.28 | -114.91, 24.81 | 310.05, 96.63 | -62.07, -19.46 | out-out | out | 11.029 | Saltbr-out | 6.97 | HRD-in | -66.51, -50.25 | 76.73, -28.84 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.868 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -112.68, 19.75 | APE9-dihe-in | -67.29, 128.45 | APE8-dihe-in | -49.93, 126.32 | APE8-rot-na | 13.1 | APE67-dihe-in | -68.28, -21.28 | -70.5, -21.67 | APE12-dist-na | 14.19 | APE11-dist-na | 10.315 | APE10-dist-na | 10.171 | APE9-dist-in | 6.356 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | L | 308 | 295 | 10 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PM | P08069 | 981 | 1285 | 1367.0 | 741:60012 | Type1.5_Front | Inactive | DFGin | 6.771 | 16.613 | ABAminus | -128.57, -42.47 | -122.66, 116.51 | -120.09, 38.47 | 314.34, 94.44 | -73.17, -23.07 | out-out | out | 11.214 | Saltbr-out | 7.332 | HRD-in | -78.25, -49.69 | 75.71, -26.22 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.877 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -117.51, 9.39 | APE9-dihe-in | -60.52, 138.49 | APE8-dihe-in | -61.63, 125.4 | APE8-rot-na | 341.15 | APE67-dihe-in | -68.1, -5.47 | -67.37, -25.72 | APE12-dist-na | 13.872 | APE11-dist-na | 10.161 | APE10-dist-na | 9.914 | APE9-dist-in | 6.394 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | M | 308 | 297 | 8 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PR | P08069 | 981 | 1285 | 1367.0 | 741:60014 | Type1.5_Front | Inactive | DFGin | 6.538 | 16.629 | ABAminus | -139.04, -20.87 | -125.55, 103.39 | -109.5, 25.04 | 311.13, 96.42 | -58.59, -20.19 | out-out | out | 11.106 | Saltbr-out | 7.253 | HRD-in | -61.08, -46.93 | 71.37, -30.05 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.994 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -121.06, 13.96 | APE9-dihe-in | -63.18, 134.5 | APE8-dihe-in | -57.6, 125.54 | APE8-rot-na | 338.75 | APE67-dihe-in | -68.47, -18.65 | -66.66, -22.95 | APE12-dist-na | 14.134 | APE11-dist-na | 10.186 | APE10-dist-na | 10.002 | APE9-dist-in | 6.439 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | R | 308 | 296 | 9 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PS | P08069 | 981 | 1286 | 1367.0 | 741:60015 | Type1.5_Front | Inactive | DFGin | 6.621 | 16.362 | ABAminus | -137.74, -25.34 | -122.78, 115.95 | -115.05, 8.88 | 304.38, 111.51 | -47.71, -27.84 | out-out | out | 11.103 | Saltbr-out | 6.886 | HRD-in | -69.09, -43.99 | 64.64, -15.6 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.902 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -120.58, 17.02 | APE9-dihe-in | -62.27, 136.85 | APE8-dihe-in | -61.63, 122.69 | APE8-rot-na | 21.86 | APE67-dihe-in | -66.47, -21.61 | -67.46, -19.45 | APE12-dist-na | 13.986 | APE11-dist-na | 10.237 | APE10-dist-na | 10.157 | APE9-dist-in | 6.245 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | S | 308 | 297 | 9 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| TYR | IGF1R | IGF1R_HUMAN | 3F5PT | P08069 | 981 | 1286 | 1367.0 | 741:60016 | Type1.5_Front | Inactive | DFGin | 6.52 | 16.375 | ABAminus | -141.26, -19.49 | -137.77, 101.2 | -103.13, 11.95 | 304.34, 96.76 | -50.98, -21.44 | out-out | out | 10.787 | Saltbr-out | 6.707 | HRD-in | -77.18, -39.29 | 69.12, -25.78 | out-in-out | SNCoio | in-out | ActLoopNT-in | 2.859 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -114.42, 13.71 | APE9-dihe-in | -68.71, 130.72 | APE8-dihe-in | -54.94, 124.12 | APE8-rot-na | 340.88 | APE67-dihe-in | -66.19, -17.17 | -61.43, -26.74 | APE12-dist-na | 13.846 | APE11-dist-na | 10.239 | APE10-dist-na | 9.88 | APE9-dist-in | 6.273 | None | PTR1161,PTR1165,PTR1166 | PTR1161,PTR1165,PTR1166 | XRAY | 2.9 | 0.212 | 0.258 | T | 308 | 297 | 9 | 0 | 0 | 0 | [[999, 1268]] | 1.0 | 3f5p | Homo sapiens | TYR_IGF1R_HUMAN | TYR | 1.9e-95 | 325.0 | 1 | 260 | 260 | 1152 | 1153 | 1154 | 1156 | 1158 | 1033 | 1050 | 1054 | 1132 | 1134 | 1133 | 1135 | 1194 | 1182 | 1177 | 1176 | 1175 | 1174 | 1173 | 1172 | 1171 | 1080 | Insulin-like growth factor 1 receptor |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
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