PDB: 2VX3 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2VX3A
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 2VX3A Q13627 135 481 763.0 D15:600 Type1 Active DFGin 7.177 14.936 BLAminus -117.81, 179.58 65.92, 72.63 -91.66, 22.61 288.71, 80.01 -64.63, -16.68 in-in in 9.357 Saltbr-in 2.613 HRD-in -69.18, -45.26 74.92, -7.88 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.77, 169.88 APE9-dihe-na 74.29, 146.1 APE8-dihe-in -68.67, 142.33 APE8-rot-in 277.43 APE67-dihe-in -61.53, -28.29 -54.62, -46.41 APE12-dist-in 12.499 APE11-dist-in 11.435 APE10-dist-in 6.965 APE9-dist-in 3.064 None PTR321 PTR321 XRAY 2.4 0.186 0.23 A 382 347 0 0 0 0 [[159, 479]] 1.0 2vx3 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2VX3B Q13627 135 480 763.0 D15:600 Type1 Active DFGin 7.264 15.037 BLAminus -122.56, -178.04 63.15, 68.41 -88.18, 26.58 286.19, 82.05 -63.3, -25.27 in-in in 9.323 Saltbr-in 2.487 HRD-in -63.29, -48.28 78.74, -5.5 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.98, 169.63 APE9-dihe-na 73.35, 142.01 APE8-dihe-in -64.13, 145.91 APE8-rot-in 293.73 APE67-dihe-in -61.18, -25.64 -59.75, -45.87 APE12-dist-in 12.788 APE11-dist-in 11.481 APE10-dist-in 7.216 APE9-dist-in 3.173 None PTR321 PTR321 XRAY 2.4 0.186 0.23 B 382 341 5 0 0 0 [[159, 479]] 1.0 2vx3 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2VX3C Q13627 135 480 763.0 D15:600 Type1 Active DFGin 7.171 15.076 BLAminus -121.44, 178.92 62.09, 79.8 -99.68, 23.42 286.42, 75.22 -71.85, -9.09 in-in in 9.284 Saltbr-in 2.559 HRD-in -69.05, -51.28 81.08, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.91, 169.36 APE9-dihe-na 73.6, 142.61 APE8-dihe-in -69.05, 142.27 APE8-rot-in 289.71 APE67-dihe-in -57.92, -27.82 -52.31, -50.36 APE12-dist-in 12.693 APE11-dist-in 11.469 APE10-dist-in 7.054 APE9-dist-in 3.198 None PTR321 PTR321 XRAY 2.4 0.186 0.23 C 382 339 7 0 0 0 [[159, 479]] 1.0 2vx3 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2VX3D Q13627 135 480 763.0 D15:600 Type1 Active DFGin 7.127 15.124 BLAminus -119.03, 173.28 66.12, 79.97 -97.89, 24.65 287.18, 77.93 -62.52, -22.35 in-in in 9.434 Saltbr-in 2.837 HRD-in -59.24, -53.5 80.78, -1.27 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.8, 170.17 APE9-dihe-na 73.1, 153.08 APE8-dihe-in -81.31, 142.62 APE8-rot-in 292.88 APE67-dihe-in -60.26, -27.62 -52.95, -48.14 APE12-dist-in 12.928 APE11-dist-in 11.48 APE10-dist-in 7.18 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.4 0.186 0.23 D 382 343 3 0 0 0 [[159, 479]] 1.0 2vx3 CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 2VX3 — CMGC DYR1A_HUMAN

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2VX3A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 2VX3A Q13627 135 481 763.0 D15:600 Type1 Active DFGin 7.177 14.936 BLAminus -117.81, 179.58 65.92, 72.63 -91.66, 22.61 288.71, 80.01 -64.63, -16.68 in-in in 9.357 Saltbr-in 2.613 HRD-in -69.18, -45.26 74.92, -7.88 in-in-in SNCiii in-in ActLoopNT-in 2.827 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.77, 169.88 APE9-dihe-na 74.29, 146.1 APE8-dihe-in -68.67, 142.33 APE8-rot-in 277.43 APE67-dihe-in -61.53, -28.29 -54.62, -46.41 APE12-dist-in 12.499 APE11-dist-in 11.435 APE10-dist-in 6.965 APE9-dist-in 3.064 None PTR321 PTR321 XRAY 2.4 0.186 0.23 A 382 347 0 0 0 0 [[159, 479]] 1.0 2vx3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2VX3B Q13627 135 480 763.0 D15:600 Type1 Active DFGin 7.264 15.037 BLAminus -122.56, -178.04 63.15, 68.41 -88.18, 26.58 286.19, 82.05 -63.3, -25.27 in-in in 9.323 Saltbr-in 2.487 HRD-in -63.29, -48.28 78.74, -5.5 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.98, 169.63 APE9-dihe-na 73.35, 142.01 APE8-dihe-in -64.13, 145.91 APE8-rot-in 293.73 APE67-dihe-in -61.18, -25.64 -59.75, -45.87 APE12-dist-in 12.788 APE11-dist-in 11.481 APE10-dist-in 7.216 APE9-dist-in 3.173 None PTR321 PTR321 XRAY 2.4 0.186 0.23 B 382 341 5 0 0 0 [[159, 479]] 1.0 2vx3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2VX3C Q13627 135 480 763.0 D15:600 Type1 Active DFGin 7.171 15.076 BLAminus -121.44, 178.92 62.09, 79.8 -99.68, 23.42 286.42, 75.22 -71.85, -9.09 in-in in 9.284 Saltbr-in 2.559 HRD-in -69.05, -51.28 81.08, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.91, 169.36 APE9-dihe-na 73.6, 142.61 APE8-dihe-in -69.05, 142.27 APE8-rot-in 289.71 APE67-dihe-in -57.92, -27.82 -52.31, -50.36 APE12-dist-in 12.693 APE11-dist-in 11.469 APE10-dist-in 7.054 APE9-dist-in 3.198 None PTR321 PTR321 XRAY 2.4 0.186 0.23 C 382 339 7 0 0 0 [[159, 479]] 1.0 2vx3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 2VX3D Q13627 135 480 763.0 D15:600 Type1 Active DFGin 7.127 15.124 BLAminus -119.03, 173.28 66.12, 79.97 -97.89, 24.65 287.18, 77.93 -62.52, -22.35 in-in in 9.434 Saltbr-in 2.837 HRD-in -59.24, -53.5 80.78, -1.27 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.8, 170.17 APE9-dihe-na 73.1, 153.08 APE8-dihe-in -81.31, 142.62 APE8-rot-in 292.88 APE67-dihe-in -60.26, -27.62 -52.95, -48.14 APE12-dist-in 12.928 APE11-dist-in 11.48 APE10-dist-in 7.18 APE9-dist-in 3.148 None PTR321 PTR321 XRAY 2.4 0.186 0.23 D 382 343 3 0 0 0 [[159, 479]] 1.0 2vx3 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB: 2VX3 — CMGC DYR1A_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name