Ligand: ZRU

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 3 100.0% 8S98C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR TYK2-1 TYK2_HUMAN 8S98A P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.3534 12.6977 None -63.41, 150.46 -40.02, 136.95 -69.11, -5.37 28.88, 139.25 79.24, -154.61 in-na in 9.6761 Saltbr-na 999.0 HRD-in -86.71, -58.07 85.92, 3.99 na-out-out SNCaoo out-out ActLoopNT-out 8.1152 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.34, -41.36 APE9-dihe-out -63.27, -26.83 APE8-dihe-out -87.06, 1.76 APE8-rot-na 289.42 APE67-dihe-out -101.27, 10.15 -70.05, 135.5 APE12-dist-na 9.7695 APE11-dist-na 12.3681 APE10-dist-na 16.5009 APE9-dist-out 11.6332 None None CSO808 XRAY 1.87 0.226 0.274 A 295.0 256.0 35 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98B P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.3388 12.942 None -54.77, 156.29 -53.9, 146.74 -74.48, -2.14 30.11, 138.2 66.75, -149.92 in-na in 9.6961 Saltbr-na 999.0 HRD-in -77.0, -58.39 85.56, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.4655 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.92, -37.3 APE9-dihe-out -60.59, -30.35 APE8-dihe-out -84.45, -1.45 APE8-rot-na 293.47 APE67-dihe-out -99.24, 10.29 -63.77, 131.59 APE12-dist-na 9.9673 APE11-dist-na 12.261 APE10-dist-na 16.5394 APE9-dist-out 11.7384 None None CSO808 XRAY 1.87 0.226 0.274 B 295.0 259.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98C P29597 578 868 1187.0 ZRU:901 Type1 Pseudo DFGin 7.5577 12.8193 None -59.14, 154.57 -51.18, 142.9 -77.73, 6.11 31.51, 139.73 67.49, -158.75 in-na in 9.6147 Saltbr-na 999.0 HRD-in -81.52, -60.95 90.44, 9.6 na-out-out SNCaoo out-out ActLoopNT-out 8.5721 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.87, -38.56 APE9-dihe-out -63.68, -27.1 APE8-dihe-out -84.04, -1.3 APE8-rot-na 288.57 APE67-dihe-out -98.82, 11.75 -65.96, 135.63 APE12-dist-na 9.9318 APE11-dist-na 12.2766 APE10-dist-na 16.5124 APE9-dist-out 11.8618 None None CSO808 XRAY 1.87 0.226 0.274 C 295.0 261.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2

Ligand: ZRU

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 3 100.0% 8S98C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR TYK2-1 TYK2_HUMAN 8S98A P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.3534 12.6977 None -63.41, 150.46 -40.02, 136.95 -69.11, -5.37 28.88, 139.25 79.24, -154.61 in-na in 9.6761 Saltbr-na 999.0 HRD-in -86.71, -58.07 85.92, 3.99 na-out-out SNCaoo out-out ActLoopNT-out 8.1152 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -59.34, -41.36 APE9-dihe-out -63.27, -26.83 APE8-dihe-out -87.06, 1.76 APE8-rot-na 289.42 APE67-dihe-out -101.27, 10.15 -70.05, 135.5 APE12-dist-na 9.7695 APE11-dist-na 12.3681 APE10-dist-na 16.5009 APE9-dist-out 11.6332 None None CSO808 XRAY 1.87 0.226 0.274 A 295.0 256.0 35 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98B P29597 578 867 1187.0 ZRU:901 Type1 Pseudo DFGin 7.3388 12.942 None -54.77, 156.29 -53.9, 146.74 -74.48, -2.14 30.11, 138.2 66.75, -149.92 in-na in 9.6961 Saltbr-na 999.0 HRD-in -77.0, -58.39 85.56, 3.19 na-out-out SNCaoo out-out ActLoopNT-out 8.4655 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.92, -37.3 APE9-dihe-out -60.59, -30.35 APE8-dihe-out -84.45, -1.45 APE8-rot-na 293.47 APE67-dihe-out -99.24, 10.29 -63.77, 131.59 APE12-dist-na 9.9673 APE11-dist-na 12.261 APE10-dist-na 16.5394 APE9-dist-out 11.7384 None None CSO808 XRAY 1.87 0.226 0.274 B 295.0 259.0 32 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 8S98C P29597 578 868 1187.0 ZRU:901 Type1 Pseudo DFGin 7.5577 12.8193 None -59.14, 154.57 -51.18, 142.9 -77.73, 6.11 31.51, 139.73 67.49, -158.75 in-na in 9.6147 Saltbr-na 999.0 HRD-in -81.52, -60.95 90.44, 9.6 na-out-out SNCaoo out-out ActLoopNT-out 8.5721 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -61.87, -38.56 APE9-dihe-out -63.68, -27.1 APE8-dihe-out -84.04, -1.3 APE8-rot-na 288.57 APE67-dihe-out -98.82, 11.75 -65.96, 135.63 APE12-dist-na 9.9318 APE11-dist-na 12.2766 APE10-dist-na 16.5124 APE9-dist-out 11.8618 None None CSO808 XRAY 1.87 0.226 0.274 C 295.0 261.0 30 24 24 0 [[589, 868], [897, 1171]] 2.0 8s98 Homo sapiens TYR_TYK2-1_HUMAN TYR 4.1e-60 209.3 2.0 260.0 259.0 758 759 760 762 764 642 658 662 731 733 732 734.0 796 782 777 776 775 774 773 772 771 688 Non-receptor tyrosine-protein kinase TYK2

Ligand: ZRU

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name