Ligand: UWP

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 6X8FC
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6X8EA O60674 843 1130 1132.0 UWP:4000 Type1 Inactive DFGin 6.257 13.614 ABAminus -104.07, -6.27 -144.33, 140.78 -129.93, 25.98 299.29, 84.64 -56.68, -27.83 in-in in 8.514 Saltbr-in 2.77 HRD-in -64.77, -46.55 65.18, -3.57 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.41 APE8-dihe-in -80.26, 70.05 APE8-rot-na 29.9 APE67-dihe-in -75.03, -3.98 -52.38, -33.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.218 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.75 0.183 0.225 A 298 274 14 0 0 4 [[545, 807], [849, 1125]] 2.0 6x8e TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6X8EB O60674 843 1132 1132.0 UWP:4001 Type1 Inactive DFGin 6.233 13.721 ABAminus -106.05, -4.78 -145.1, 140.25 -129.47, 26.42 299.09, 84.77 -55.74, -27.96 in-in in 8.485 Saltbr-in 2.791 HRD-in -65.28, -46.37 65.46, -3.84 in-in-none SNCiin in-none ActLoopNT-in 2.89 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.68 APE8-dihe-in -81.95, 68.62 APE8-rot-na 30.25 APE67-dihe-in -74.54, -2.39 -53.13, -32.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.287 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.75 0.183 0.225 B 298 281 9 0 0 5 [[545, 807], [849, 1125]] 2.0 6x8e TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 6X8FA P29597 889 1178 1187.0 UWP:4001 Type1 Inactive DFGin 6.368 13.443 ABAminus -95.56, -18.62 -136.08, 142.25 -132.97, 38.39 300.79, 80.69 -60.74, -30.23 in-in in 8.59 Saltbr-in 2.814 HRD-in -80.09, -50.24 67.91, 4.2 in-in-out SNCiio in-out ActLoopNT-in 2.813 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -85.77, 10.94 APE9-dihe-in -74.28, 130.62 APE8-dihe-in -82.04, 69.42 APE8-rot-na 28.67 APE67-dihe-in -81.13, -2.61 -51.22, -29.34 APE12-dist-na 9.813 APE11-dist-na 12.675 APE10-dist-na 9.193 APE9-dist-in 6.525 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.15 0.208 0.255 A 318 283 7 0 0 0 [[589, 868], [897, 1171]] 2.0 6x8f TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 6X8FC P29597 889 1178 1187.0 UWP:4000 Type1 Inactive DFGin 6.411 13.467 ABAminus -95.34, -17.32 -136.72, 141.32 -133.98, 37.29 300.65, 80.99 -60.17, -32.21 in-in in 8.489 Saltbr-in 2.696 HRD-in -78.97, -50.37 67.86, 4.05 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.16, 9.73 APE9-dihe-in -74.69, 130.77 APE8-dihe-in -82.29, 70.3 APE8-rot-na 28.25 APE67-dihe-in -80.62, -2.35 -52.14, -29.87 APE12-dist-na 10.892 APE11-dist-na 12.859 APE10-dist-na 9.189 APE9-dist-in 6.55 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.15 0.208 0.255 C 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6x8f TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: UWP

Total number of chains: 4
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 6X8FC
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6X8EA O60674 843 1130 1132.0 UWP:4000 Type1 Inactive DFGin 6.257 13.614 ABAminus -104.07, -6.27 -144.33, 140.78 -129.93, 25.98 299.29, 84.64 -56.68, -27.83 in-in in 8.514 Saltbr-in 2.77 HRD-in -64.77, -46.55 65.18, -3.57 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.41 APE8-dihe-in -80.26, 70.05 APE8-rot-na 29.9 APE67-dihe-in -75.03, -3.98 -52.38, -33.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.218 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.75 0.183 0.225 A 298 274 14 0 0 4 [[545, 807], [849, 1125]] 2.0 6x8e Homo sapiens TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6X8EB O60674 843 1132 1132.0 UWP:4001 Type1 Inactive DFGin 6.233 13.721 ABAminus -106.05, -4.78 -145.1, 140.25 -129.47, 26.42 299.09, 84.77 -55.74, -27.96 in-in in 8.485 Saltbr-in 2.791 HRD-in -65.28, -46.37 65.46, -3.84 in-in-none SNCiin in-none ActLoopNT-in 2.89 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.68 APE8-dihe-in -81.95, 68.62 APE8-rot-na 30.25 APE67-dihe-in -74.54, -2.39 -53.13, -32.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.287 M1073S,F1076T PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.75 0.183 0.225 B 298 281 9 0 0 5 [[545, 807], [849, 1125]] 2.0 6x8e Homo sapiens TYR_JAK2-2_HUMAN TYR 6.1e-87 297.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 6X8FA P29597 889 1178 1187.0 UWP:4001 Type1 Inactive DFGin 6.368 13.443 ABAminus -95.56, -18.62 -136.08, 142.25 -132.97, 38.39 300.79, 80.69 -60.74, -30.23 in-in in 8.59 Saltbr-in 2.814 HRD-in -80.09, -50.24 67.91, 4.2 in-in-out SNCiio in-out ActLoopNT-in 2.813 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -85.77, 10.94 APE9-dihe-in -74.28, 130.62 APE8-dihe-in -82.04, 69.42 APE8-rot-na 28.67 APE67-dihe-in -81.13, -2.61 -51.22, -29.34 APE12-dist-na 9.813 APE11-dist-na 12.675 APE10-dist-na 9.193 APE9-dist-in 6.525 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.15 0.208 0.255 A 318 283 7 0 0 0 [[589, 868], [897, 1171]] 2.0 6x8f Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 6X8FC P29597 889 1178 1187.0 UWP:4000 Type1 Inactive DFGin 6.411 13.467 ABAminus -95.34, -17.32 -136.72, 141.32 -133.98, 37.29 300.65, 80.99 -60.17, -32.21 in-in in 8.489 Saltbr-in 2.696 HRD-in -78.97, -50.37 67.86, 4.05 in-in-out SNCiio in-out ActLoopNT-in 2.808 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -92.16, 9.73 APE9-dihe-in -74.69, 130.77 APE8-dihe-in -82.29, 70.3 APE8-rot-na 28.25 APE67-dihe-in -80.62, -2.35 -52.14, -29.87 APE12-dist-na 10.892 APE11-dist-na 12.859 APE10-dist-na 9.189 APE9-dist-in 6.55 C936A,Q969A,E971A,K972A,A1016S,C1142A PTR1054 PTR1054 XRAY 2.15 0.208 0.255 C 318 290 0 0 0 0 [[589, 868], [897, 1171]] 2.0 6x8f Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: UWP

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name