Ligand: UUB

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 7NXKA
DFGin BLAminus 1 50.0% 7NXKC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 7NXKA Q9NYV4 715 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.3995 15.4871 ABAminus -95.46, -72.72 -129.88, 136.0 -106.22, 48.24 290.77, 75.67 -65.42, -30.99 in-none in 8.908 Saltbr-none 999.0 HRD-out -77.5, 146.77 -128.84, 17.49 none-in-out SNCnio in-out ActLoopNT-in 2.9696 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.63, -48.96 APE9-dihe-na -98.39, 153.96 APE8-dihe-in -58.36, 147.85 APE8-rot-out 42.54 APE67-dihe-in -71.34, -26.96 -59.32, -29.48 APE12-dist-in 12.8425 APE11-dist-in 11.1162 APE10-dist-in 6.7497 APE9-dist-in 3.4451 None TPO893 TPO893 XRAY 3.0 0.222 0.264 A 351.0 322.0 4 29 29 0 [[727, 1020]] 1.0 7nxk CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 7NXKC Q9NYV4 717 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.2388 15.3617 BLAminus -141.93, -168.1 55.29, 66.48 -89.47, 23.2 285.63, 87.42 -65.95, -22.63 in-none in 9.1644 Saltbr-none 999.0 HRD-in -59.09, -64.11 84.9, -5.29 none-in-out SNCnio in-out ActLoopNT-in 3.0998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.36, -24.98 APE9-dihe-na -111.23, 152.03 APE8-dihe-in -58.18, 144.58 APE8-rot-out 41.59 APE67-dihe-in -69.39, -10.03 -63.92, -28.51 APE12-dist-in 13.0199 APE11-dist-in 11.29 APE10-dist-in 6.4678 APE9-dist-in 3.4673 None TPO893 TPO893 XRAY 3.0 0.222 0.264 C 351.0 314.0 10 29 29 0 [[727, 1020]] 1.0 7nxk CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: UUB

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 7NXKA
DFGin BLAminus 1 50.0% 7NXKC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 7NXKA Q9NYV4 715 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.3995 15.4871 ABAminus -95.46, -72.72 -129.88, 136.0 -106.22, 48.24 290.77, 75.67 -65.42, -30.99 in-none in 8.908 Saltbr-none 999.0 HRD-out -77.5, 146.77 -128.84, 17.49 none-in-out SNCnio in-out ActLoopNT-in 2.9696 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -137.63, -48.96 APE9-dihe-na -98.39, 153.96 APE8-dihe-in -58.36, 147.85 APE8-rot-out 42.54 APE67-dihe-in -71.34, -26.96 -59.32, -29.48 APE12-dist-in 12.8425 APE11-dist-in 11.1162 APE10-dist-in 6.7497 APE9-dist-in 3.4451 None TPO893 TPO893 XRAY 3.0 0.222 0.264 A 351.0 322.0 4 29 29 0 [[727, 1020]] 1.0 7nxk Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 7NXKC Q9NYV4 717 1040 1490.0 UUB:2000 Type1 Inactive DFGin 7.2388 15.3617 BLAminus -141.93, -168.1 55.29, 66.48 -89.47, 23.2 285.63, 87.42 -65.95, -22.63 in-none in 9.1644 Saltbr-none 999.0 HRD-in -59.09, -64.11 84.9, -5.29 none-in-out SNCnio in-out ActLoopNT-in 3.0998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.36, -24.98 APE9-dihe-na -111.23, 152.03 APE8-dihe-in -58.18, 144.58 APE8-rot-out 41.59 APE67-dihe-in -69.39, -10.03 -63.92, -28.51 APE12-dist-in 13.0199 APE11-dist-in 11.29 APE10-dist-in 6.4678 APE9-dist-in 3.4673 None TPO893 TPO893 XRAY 3.0 0.222 0.264 C 351.0 314.0 10 29 29 0 [[727, 1020]] 1.0 7nxk Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: UUB

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name