Ligand: RP9

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 8BUDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUDB Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.8061 15.4238 ABAminus -142.15, -16.91 -106.36, 87.13 -96.45, 32.21 289.44, 76.45 -77.57, -27.46 in-in in 8.0202 Saltbr-in 3.4896 HRD-in -66.52, -51.15 74.89, 1.88 in-in-in SNCiii in-in ActLoopNT-in 2.9309 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.04, -21.52 APE9-dihe-na -109.6, 155.4 APE8-dihe-in -62.09, 142.67 APE8-rot-in 309.35 APE67-dihe-in -60.6, -25.6 -60.57, -39.4 APE12-dist-in 13.1906 APE11-dist-in 11.7357 APE10-dist-in 6.6928 APE9-dist-in 3.6946 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUDH Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.9462 15.3566 ABAminus -136.05, -39.21 -99.68, 89.69 -94.42, 33.08 285.78, 76.86 -80.16, -27.09 in-in in 7.932 Saltbr-in 3.0948 HRD-in -68.45, -57.7 74.71, 4.44 in-in-in SNCiii in-in ActLoopNT-in 2.8947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.74, -26.44 APE9-dihe-na -108.9, 157.16 APE8-dihe-in -60.21, 144.65 APE8-rot-in 297.94 APE67-dihe-in -60.44, -27.56 -58.25, -38.75 APE12-dist-in 13.6485 APE11-dist-in 11.7344 APE10-dist-in 7.1594 APE9-dist-in 3.6555 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RP9

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 8BUDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUDB Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.8061 15.4238 ABAminus -142.15, -16.91 -106.36, 87.13 -96.45, 32.21 289.44, 76.45 -77.57, -27.46 in-in in 8.0202 Saltbr-in 3.4896 HRD-in -66.52, -51.15 74.89, 1.88 in-in-in SNCiii in-in ActLoopNT-in 2.9309 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.04, -21.52 APE9-dihe-na -109.6, 155.4 APE8-dihe-in -62.09, 142.67 APE8-rot-in 309.35 APE67-dihe-in -60.6, -25.6 -60.57, -39.4 APE12-dist-in 13.1906 APE11-dist-in 11.7357 APE10-dist-in 6.6928 APE9-dist-in 3.6946 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 B 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUDH Q9NYV4 715 1043 1490.0 RP9:61101 Type1 Inactive DFGin 6.9462 15.3566 ABAminus -136.05, -39.21 -99.68, 89.69 -94.42, 33.08 285.78, 76.86 -80.16, -27.09 in-in in 7.932 Saltbr-in 3.0948 HRD-in -68.45, -57.7 74.71, 4.44 in-in-in SNCiii in-in ActLoopNT-in 2.8947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.74, -26.44 APE9-dihe-na -108.9, 157.16 APE8-dihe-in -60.21, 144.65 APE8-rot-in 297.94 APE67-dihe-in -60.44, -27.56 -58.25, -38.75 APE12-dist-in 13.6485 APE11-dist-in 11.7344 APE10-dist-in 7.1594 APE9-dist-in 3.6555 K965R TPO893 TPO893 XRAY 3.2 0.191 0.22 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bud Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RP9

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name