Ligand: RNU

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 8BUBB
DFGin None 1 33.3% 8BUBH
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUBB Q9NYV4 715 1041 1490.0 RNU:61101 Type1 Inactive DFGin 7.183 15.8614 BLAminus -140.81, -179.71 59.34, 42.69 -57.7, -43.03 281.93, 72.19 -135.84, 169.59 in-in in 7.8158 Saltbr-in 3.0301 HRD-out -85.59, 106.33 -67.25, -35.7 in-out-out SNCioo out-out ActLoopNT-out 15.0827 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.9, -41.94 APE9-dihe-na -63.9, -43.28 APE8-dihe-out -57.35, -36.53 APE8-rot-in 303.78 APE67-dihe-in -55.9, -22.59 -60.27, -40.25 APE12-dist-in 10.517 APE11-dist-in 13.5215 APE10-dist-out 17.3786 APE9-dist-out 11.733 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUBE Q9NYV4 715 1043 1490.0 RNU:61101 Type1 Inactive DFGin 7.1209 15.7177 BLAminus -151.03, 179.83 54.33, 46.25 -61.28, -40.39 279.04, 68.48 -138.85, 169.0 in-in in 8.2609 Saltbr-in 2.9133 HRD-out -90.61, 99.83 -68.22, -35.13 in-out-out SNCioo out-out ActLoopNT-out 14.6238 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -60.24, -43.43 APE9-dihe-na -66.88, -44.0 APE8-dihe-out -57.36, -41.95 APE8-rot-in 294.1 APE67-dihe-in -53.67, -21.91 -61.1, -39.92 APE12-dist-in 10.606 APE11-dist-out 14.7928 APE10-dist-out 17.9151 APE9-dist-out 11.2983 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUBH Q9NYV4 715 1044 1490.0 RNU:61102 Type1 Inactive DFGin 7.2638 15.677 None -126.03, -25.89 -87.61, 72.88 -91.51, 12.82 280.63, 73.67 -60.75, -39.82 in-in in 8.4819 Saltbr-in 3.5525 HRD-out -79.78, 93.25 -67.97, -38.17 in-out-out SNCioo out-out ActLoopNT-out 3.72 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -109.56, -9.94 APE9-dihe-na -106.55, 22.31 APE8-dihe-out 64.82, 23.4 APE8-rot-out 71.99 APE67-dihe-out -104.68, -30.69 71.46, -1.72 APE12-dist-in 12.7113 APE11-dist-in 12.093 APE10-dist-in 6.8605 APE9-dist-in 4.5978 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bub CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RNU

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 8BUBB
DFGin None 1 33.3% 8BUBH
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK12 CDK12_HUMAN 8BUBB Q9NYV4 715 1041 1490.0 RNU:61101 Type1 Inactive DFGin 7.183 15.8614 BLAminus -140.81, -179.71 59.34, 42.69 -57.7, -43.03 281.93, 72.19 -135.84, 169.59 in-in in 7.8158 Saltbr-in 3.0301 HRD-out -85.59, 106.33 -67.25, -35.7 in-out-out SNCioo out-out ActLoopNT-out 15.0827 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.9, -41.94 APE9-dihe-na -63.9, -43.28 APE8-dihe-out -57.35, -36.53 APE8-rot-in 303.78 APE67-dihe-in -55.9, -22.59 -60.27, -40.25 APE12-dist-in 10.517 APE11-dist-in 13.5215 APE10-dist-out 17.3786 APE9-dist-out 11.733 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUBE Q9NYV4 715 1043 1490.0 RNU:61101 Type1 Inactive DFGin 7.1209 15.7177 BLAminus -151.03, 179.83 54.33, 46.25 -61.28, -40.39 279.04, 68.48 -138.85, 169.0 in-in in 8.2609 Saltbr-in 2.9133 HRD-out -90.61, 99.83 -68.22, -35.13 in-out-out SNCioo out-out ActLoopNT-out 14.6238 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -60.24, -43.43 APE9-dihe-na -66.88, -44.0 APE8-dihe-out -57.36, -41.95 APE8-rot-in 294.1 APE67-dihe-in -53.67, -21.91 -61.1, -39.92 APE12-dist-in 10.606 APE11-dist-out 14.7928 APE10-dist-out 17.9151 APE9-dist-out 11.2983 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 E 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUBH Q9NYV4 715 1044 1490.0 RNU:61102 Type1 Inactive DFGin 7.2638 15.677 None -126.03, -25.89 -87.61, 72.88 -91.51, 12.82 280.63, 73.67 -60.75, -39.82 in-in in 8.4819 Saltbr-in 3.5525 HRD-out -79.78, 93.25 -67.97, -38.17 in-out-out SNCioo out-out ActLoopNT-out 3.72 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -109.56, -9.94 APE9-dihe-na -106.55, 22.31 APE8-dihe-out 64.82, 23.4 APE8-rot-out 71.99 APE67-dihe-out -104.68, -30.69 71.46, -1.72 APE12-dist-in 12.7113 APE11-dist-in 12.093 APE10-dist-in 6.8605 APE9-dist-in 4.5978 K965R TPO893 TPO893 XRAY 3.42 0.213 0.237 H 344.0 330.0 0 29 29 0 [[727, 1020]] 1.0 8bub Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12

Ligand: RNU

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name