Ligand: RFZ

Total number of chains: 5
Active chains: 5
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 3H30B
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 3MY5A P24941 1 298 298.0 RFZ:60300 Type1 Active DFGin 6.667 15.348 BLAminus -135.55, -178.04 53.6, 76.52 -97.01, 15.67 276.61, 75.78 -59.51, -26.48 in-in in 8.74 Saltbr-in 2.765 HRD-in -79.62, -51.44 67.18, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.67, 153.77 APE9-dihe-na 76.12, 127.46 APE8-dihe-in -56.8, 137.09 APE8-rot-in 303.01 APE67-dihe-in -62.09, -25.12 -50.14, -44.68 APE12-dist-in 13.142 APE11-dist-in 10.346 APE10-dist-in 7.108 APE9-dist-in 3.243 None TPO160 TPO160 XRAY 2.1 0.182 0.219 A 300 295 3 0 0 0 [[4, 286]] 1.0 3my5 CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3MY5C P24941 1 296 298.0 RFZ:60301 Type1 Active DFGin 6.72 15.383 BLAminus -140.83, -171.85 49.57, 71.36 -87.98, 20.89 279.16, 71.11 -63.16, -26.32 in-in in 8.599 Saltbr-in 2.699 HRD-in -80.11, -52.55 69.91, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.93, 151.21 APE9-dihe-na 70.99, 122.72 APE8-dihe-in -51.33, 141.26 APE8-rot-in 307.41 APE67-dihe-in -61.95, -24.04 -45.65, -48.3 APE12-dist-in 12.729 APE11-dist-in 9.812 APE10-dist-in 6.813 APE9-dist-in 3.261 None TPO160 TPO160 XRAY 2.1 0.182 0.219 C 300 266 30 0 0 0 [[4, 286]] 1.0 3my5 CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK9 CDK9_HUMAN 3MY1A P50750 6 327 372.0 RFZ:336 Type1 Active DFGin 6.92 14.737 BLAminus -138.6, -178.76 55.85, 82.27 -96.58, 26.19 286.18, 71.12 -65.01, -22.99 in-in in 9.174 Saltbr-in 3.024 HRD-in -74.76, -49.19 65.23, 25.42 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.34, 163.18 APE9-dihe-na 70.44, 131.12 APE8-dihe-in -41.78, 152.21 APE8-rot-in 296.57 APE67-dihe-in -62.52, -36.66 -60.91, -51.23 APE12-dist-in 13.127 APE11-dist-in 11.22 APE10-dist-in 6.853 APE9-dist-in 3.38 None TPO186 TPO186 XRAY 2.8 0.175 0.214 A 331 315 7 0 0 0 [[19, 315]] 1.0 3my1 CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 3H30B P68400 2 334 391.0 RFZ:336 Type1 Active DFGin 7.456 16.006 BLAminus -121.2, -177.83 50.16, 78.47 -91.32, 16.71 294.46, 81.2 -67.28, -17.25 in-in in 9.754 Saltbr-in 2.816 HRD-in -73.44, -46.19 70.73, 6.27 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.81, 161.54 APE9-dihe-na 72.36, 159.32 APE8-dihe-in -83.53, 154.64 APE8-rot-in 275.73 APE67-dihe-in -66.72, -16.57 -46.01, -48.92 APE12-dist-in 12.221 APE11-dist-in 9.556 APE10-dist-in 5.715 APE9-dist-in 3.241 None None None XRAY 1.56 0.157 0.198 B 334 333 0 0 0 0 [[39, 324]] 1.0 3h30 CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3H30A P68400 2 334 391.0 RFZ:336,RFZ:337 Type1,Allosteric Active DFGin 7.305 16.058 BLAminus -122.05, -178.36 67.26, 61.9 -89.53, 18.61 298.78, 84.71 -69.6, -23.95 in-in in 9.842 Saltbr-in 2.963 HRD-in -71.87, -53.95 70.9, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.59, 165.18 APE9-dihe-na 65.63, 145.84 APE8-dihe-in -78.59, 146.66 APE8-rot-in 306.03 APE67-dihe-in -67.49, -16.87 -42.57, -51.44 APE12-dist-in 12.562 APE11-dist-in 9.648 APE10-dist-in 6.243 APE9-dist-in 3.231 None None None XRAY 1.56 0.157 0.198 A 334 333 0 0 0 0 [[39, 324]] 1.0 3h30 CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha

Ligand: RFZ

Total number of chains: 5
Active chains: 5
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 3H30B
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 3MY5A P24941 1 298 298.0 RFZ:60300 Type1 Active DFGin 6.667 15.348 BLAminus -135.55, -178.04 53.6, 76.52 -97.01, 15.67 276.61, 75.78 -59.51, -26.48 in-in in 8.74 Saltbr-in 2.765 HRD-in -79.62, -51.44 67.18, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.67, 153.77 APE9-dihe-na 76.12, 127.46 APE8-dihe-in -56.8, 137.09 APE8-rot-in 303.01 APE67-dihe-in -62.09, -25.12 -50.14, -44.68 APE12-dist-in 13.142 APE11-dist-in 10.346 APE10-dist-in 7.108 APE9-dist-in 3.243 None TPO160 TPO160 XRAY 2.1 0.182 0.219 A 300 295 3 0 0 0 [[4, 286]] 1.0 3my5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3MY5C P24941 1 296 298.0 RFZ:60301 Type1 Active DFGin 6.72 15.383 BLAminus -140.83, -171.85 49.57, 71.36 -87.98, 20.89 279.16, 71.11 -63.16, -26.32 in-in in 8.599 Saltbr-in 2.699 HRD-in -80.11, -52.55 69.91, 13.09 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.93, 151.21 APE9-dihe-na 70.99, 122.72 APE8-dihe-in -51.33, 141.26 APE8-rot-in 307.41 APE67-dihe-in -61.95, -24.04 -45.65, -48.3 APE12-dist-in 12.729 APE11-dist-in 9.812 APE10-dist-in 6.813 APE9-dist-in 3.261 None TPO160 TPO160 XRAY 2.1 0.182 0.219 C 300 266 30 0 0 0 [[4, 286]] 1.0 3my5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK9 CDK9_HUMAN 3MY1A P50750 6 327 372.0 RFZ:336 Type1 Active DFGin 6.92 14.737 BLAminus -138.6, -178.76 55.85, 82.27 -96.58, 26.19 286.18, 71.12 -65.01, -22.99 in-in in 9.174 Saltbr-in 3.024 HRD-in -74.76, -49.19 65.23, 25.42 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.34, 163.18 APE9-dihe-na 70.44, 131.12 APE8-dihe-in -41.78, 152.21 APE8-rot-in 296.57 APE67-dihe-in -62.52, -36.66 -60.91, -51.23 APE12-dist-in 13.127 APE11-dist-in 11.22 APE10-dist-in 6.853 APE9-dist-in 3.38 None TPO186 TPO186 XRAY 2.8 0.175 0.214 A 331 315 7 0 0 0 [[19, 315]] 1.0 3my1 Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 3H30B P68400 2 334 391.0 RFZ:336 Type1 Active DFGin 7.456 16.006 BLAminus -121.2, -177.83 50.16, 78.47 -91.32, 16.71 294.46, 81.2 -67.28, -17.25 in-in in 9.754 Saltbr-in 2.816 HRD-in -73.44, -46.19 70.73, 6.27 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.81, 161.54 APE9-dihe-na 72.36, 159.32 APE8-dihe-in -83.53, 154.64 APE8-rot-in 275.73 APE67-dihe-in -66.72, -16.57 -46.01, -48.92 APE12-dist-in 12.221 APE11-dist-in 9.556 APE10-dist-in 5.715 APE9-dist-in 3.241 None None None XRAY 1.56 0.157 0.198 B 334 333 0 0 0 0 [[39, 324]] 1.0 3h30 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3H30A P68400 2 334 391.0 RFZ:336,RFZ:337 Type1,Allosteric Active DFGin 7.305 16.058 BLAminus -122.05, -178.36 67.26, 61.9 -89.53, 18.61 298.78, 84.71 -69.6, -23.95 in-in in 9.842 Saltbr-in 2.963 HRD-in -71.87, -53.95 70.9, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.59, 165.18 APE9-dihe-na 65.63, 145.84 APE8-dihe-in -78.59, 146.66 APE8-rot-in 306.03 APE67-dihe-in -67.49, -16.87 -42.57, -51.44 APE12-dist-in 12.562 APE11-dist-in 9.648 APE10-dist-in 6.243 APE9-dist-in 3.231 None None None XRAY 1.56 0.157 0.198 A 334 333 0 0 0 0 [[39, 324]] 1.0 3h30 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha

Ligand: RFZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name