Ligand: R6V

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 6VS3A
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6VNCA O60674 840 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.175 13.178 ABAminus -125.0, 1.92 -144.44, 138.94 -134.55, 26.62 299.16, 82.3 -63.96, -13.53 in-in in 8.732 Saltbr-in 3.231 HRD-in -71.26, -46.55 70.57, -1.02 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.44, 156.2 APE9-dihe-in -132.4, 123.78 APE8-dihe-in -79.65, 76.35 APE8-rot-na 29.35 APE67-dihe-in -79.45, -6.71 -61.99, -27.52 APE12-dist-na 12.877 APE11-dist-na 8.486 APE10-dist-na 9.116 APE9-dist-in 6.852 None PTR1007 PTR1007 XRAY 2.3 0.227 0.269 A 308 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnc TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNCB O60674 843 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.154 13.17 ABAminus -122.12, 1.77 -145.07, 140.87 -135.43, 27.24 299.55, 83.32 -63.99, -17.1 in-in in 8.871 Saltbr-in 2.922 HRD-in -71.34, -45.2 70.18, -2.12 in-in-in SNCiii in-in ActLoopNT-in 2.751 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.37, 171.08 APE9-dihe-in -127.34, 149.39 APE8-dihe-in -72.05, 74.05 APE8-rot-na 32.11 APE67-dihe-in -79.07, -5.61 -65.16, -22.9 APE12-dist-na 12.808 APE11-dist-na 12.821 APE10-dist-na 13.914 APE9-dist-in 7.934 None PTR1007 PTR1007 XRAY 2.3 0.227 0.269 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnc TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VS3A O60674 843 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.172 13.4 ABAminus -113.69, -9.73 -145.44, 139.92 -129.95, 28.79 298.53, 82.06 -63.1, -23.05 in-in in 8.628 Saltbr-in 2.665 HRD-in -70.46, -47.53 70.83, 1.7 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.96, 143.74 APE9-dihe-in -124.34, 136.67 APE8-dihe-in -71.53, 71.61 APE8-rot-na 30.56 APE67-dihe-in -80.97, -2.5 -64.33, -23.02 APE12-dist-na 13.534 APE11-dist-na 12.192 APE10-dist-na 12.955 APE9-dist-in 7.731 None PTR1007 PTR1007 XRAY 2.0 0.186 0.218 A 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vs3 TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VS3B O60674 840 1132 1132.0 R6V:61201 Type1 Inactive DFGin 6.448 13.651 ABAminus -115.02, -9.81 -144.91, 138.32 -130.18, 30.61 296.48, 83.03 -64.54, -21.19 in-in in 8.591 Saltbr-in 2.758 HRD-in -72.75, -48.7 73.41, 1.11 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.71, 137.37 APE9-dihe-in -128.13, 115.26 APE8-dihe-in -80.11, 76.19 APE8-rot-na 29.15 APE67-dihe-in -81.55, -1.54 -62.24, -25.56 APE12-dist-na 13.482 APE11-dist-na 9.569 APE10-dist-na 8.843 APE9-dist-in 6.816 None PTR1007 PTR1007 XRAY 2.0 0.186 0.218 B 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vs3 TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: R6V

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 4 100.0% 6VS3A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6VNCA O60674 840 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.175 13.178 ABAminus -125.0, 1.92 -144.44, 138.94 -134.55, 26.62 299.16, 82.3 -63.96, -13.53 in-in in 8.732 Saltbr-in 3.231 HRD-in -71.26, -46.55 70.57, -1.02 in-in-in SNCiii in-in ActLoopNT-in 2.753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.44, 156.2 APE9-dihe-in -132.4, 123.78 APE8-dihe-in -79.65, 76.35 APE8-rot-na 29.35 APE67-dihe-in -79.45, -6.71 -61.99, -27.52 APE12-dist-na 12.877 APE11-dist-na 8.486 APE10-dist-na 9.116 APE9-dist-in 6.852 None PTR1007 PTR1007 XRAY 2.3 0.227 0.269 A 308 292 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNCB O60674 843 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.154 13.17 ABAminus -122.12, 1.77 -145.07, 140.87 -135.43, 27.24 299.55, 83.32 -63.99, -17.1 in-in in 8.871 Saltbr-in 2.922 HRD-in -71.34, -45.2 70.18, -2.12 in-in-in SNCiii in-in ActLoopNT-in 2.751 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.37, 171.08 APE9-dihe-in -127.34, 149.39 APE8-dihe-in -72.05, 74.05 APE8-rot-na 32.11 APE67-dihe-in -79.07, -5.61 -65.16, -22.9 APE12-dist-na 12.808 APE11-dist-na 12.821 APE10-dist-na 13.914 APE9-dist-in 7.934 None PTR1007 PTR1007 XRAY 2.3 0.227 0.269 B 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vnc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VS3A O60674 843 1131 1132.0 R6V:61201 Type1 Inactive DFGin 6.172 13.4 ABAminus -113.69, -9.73 -145.44, 139.92 -129.95, 28.79 298.53, 82.06 -63.1, -23.05 in-in in 8.628 Saltbr-in 2.665 HRD-in -70.46, -47.53 70.83, 1.7 in-in-in SNCiii in-in ActLoopNT-in 2.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.96, 143.74 APE9-dihe-in -124.34, 136.67 APE8-dihe-in -71.53, 71.61 APE8-rot-na 30.56 APE67-dihe-in -80.97, -2.5 -64.33, -23.02 APE12-dist-na 13.534 APE11-dist-na 12.192 APE10-dist-na 12.955 APE9-dist-in 7.731 None PTR1007 PTR1007 XRAY 2.0 0.186 0.218 A 308 289 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vs3 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VS3B O60674 840 1132 1132.0 R6V:61201 Type1 Inactive DFGin 6.448 13.651 ABAminus -115.02, -9.81 -144.91, 138.32 -130.18, 30.61 296.48, 83.03 -64.54, -21.19 in-in in 8.591 Saltbr-in 2.758 HRD-in -72.75, -48.7 73.41, 1.11 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.71, 137.37 APE9-dihe-in -128.13, 115.26 APE8-dihe-in -80.11, 76.19 APE8-rot-na 29.15 APE67-dihe-in -81.55, -1.54 -62.24, -25.56 APE12-dist-na 13.482 APE11-dist-na 9.569 APE10-dist-na 8.843 APE9-dist-in 6.816 None PTR1007 PTR1007 XRAY 2.0 0.186 0.218 B 308 293 0 0 0 0 [[545, 807], [849, 1125]] 2.0 6vs3 Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: R6V

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name