Ligand: R6P

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6VNBA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6VNBA O60674 840 1132 1132.0 R6P:61201 Type1 Inactive DFGin 6.35 13.558 ABAminus -118.62, -19.62 -134.83, 143.12 -133.38, 24.47 298.28, 91.33 -62.05, -22.2 in-in in 8.7036 Saltbr-in 3.0375 HRD-in -74.06, -49.4 74.99, -5.13 in-in-in SNCiii in-in ActLoopNT-in 2.7773 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.81, 144.4 APE9-dihe-in -128.3, 128.29 APE8-dihe-in -78.46, 78.55 APE8-rot-na 29.64 APE67-dihe-in -84.54, -4.75 -64.16, -21.71 APE12-dist-na 13.1548 APE11-dist-na 9.3779 APE10-dist-na 9.993 APE9-dist-in 6.9248 None PTR1007 PTR1007 XRAY 2.19 0.217 0.261 A 308.0 293.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnb TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNBB O60674 843 1131 1132.0 R6P:61201 Type1 Inactive DFGin 6.1508 13.5167 ABAminus -116.85, -18.84 -135.3, 144.45 -134.76, 23.18 296.23, 88.9 -62.89, -23.75 in-in in 8.742 Saltbr-in 2.8347 HRD-in -73.15, -47.55 74.78, -6.06 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.7, 141.71 APE9-dihe-in -125.69, 135.6 APE8-dihe-in -71.63, 74.77 APE8-rot-na 30.51 APE67-dihe-in -85.73, -5.2 -67.19, -19.79 APE12-dist-na 13.1479 APE11-dist-na 12.0446 APE10-dist-na 12.9484 APE9-dist-in 7.8693 None PTR1007 PTR1007 XRAY 2.19 0.217 0.261 B 308.0 289.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnb TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: R6P

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6VNBA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6VNBA O60674 840 1132 1132.0 R6P:61201 Type1 Inactive DFGin 6.35 13.558 ABAminus -118.62, -19.62 -134.83, 143.12 -133.38, 24.47 298.28, 91.33 -62.05, -22.2 in-in in 8.7036 Saltbr-in 3.0375 HRD-in -74.06, -49.4 74.99, -5.13 in-in-in SNCiii in-in ActLoopNT-in 2.7773 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.81, 144.4 APE9-dihe-in -128.3, 128.29 APE8-dihe-in -78.46, 78.55 APE8-rot-na 29.64 APE67-dihe-in -84.54, -4.75 -64.16, -21.71 APE12-dist-na 13.1548 APE11-dist-na 9.3779 APE10-dist-na 9.993 APE9-dist-in 6.9248 None PTR1007 PTR1007 XRAY 2.19 0.217 0.261 A 308.0 293.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnb Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNBB O60674 843 1131 1132.0 R6P:61201 Type1 Inactive DFGin 6.1508 13.5167 ABAminus -116.85, -18.84 -135.3, 144.45 -134.76, 23.18 296.23, 88.9 -62.89, -23.75 in-in in 8.742 Saltbr-in 2.8347 HRD-in -73.15, -47.55 74.78, -6.06 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.7, 141.71 APE9-dihe-in -125.69, 135.6 APE8-dihe-in -71.63, 74.77 APE8-rot-na 30.51 APE67-dihe-in -85.73, -5.2 -67.19, -19.79 APE12-dist-na 13.1479 APE11-dist-na 12.0446 APE10-dist-na 12.9484 APE9-dist-in 7.8693 None PTR1007 PTR1007 XRAY 2.19 0.217 0.261 B 308.0 289.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnb Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: R6P

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name