Ligand: R5Y

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6VNMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6VNMA O60674 840 1132 1132.0 R5Y:61201 Type1 Inactive DFGin 6.2756 13.8556 ABAminus -161.76, 45.15 -147.28, 91.94 -100.3, 24.04 301.04, 88.04 -66.18, -22.04 in-in in 8.4455 Saltbr-in 2.7946 HRD-in -70.38, -47.67 75.09, -3.21 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.31, 147.1 APE9-dihe-in -133.78, 127.05 APE8-dihe-in -79.36, 82.18 APE8-rot-na 30.27 APE67-dihe-in -79.86, -2.09 -63.93, -27.28 APE12-dist-na 13.1602 APE11-dist-na 9.3366 APE10-dist-na 9.9005 APE9-dist-in 7.0784 None PTR1007 PTR1007 XRAY 2.2 0.2 0.238 A 308.0 293.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnm TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNMB O60674 843 1131 1132.0 R5Y:61201 Type1 Inactive DFGin 6.1813 13.7293 ABAminus -117.34, 7.17 -155.1, 140.98 -137.24, 30.83 296.86, 88.07 -64.53, -27.32 in-in in 8.4978 Saltbr-in 2.6668 HRD-in -72.3, -46.39 69.83, 0.54 in-in-in SNCiii in-in ActLoopNT-in 2.8402 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.62, 127.37 APE9-dihe-in -107.62, 146.18 APE8-dihe-in -72.44, 70.75 APE8-rot-na 28.98 APE67-dihe-in -82.72, -2.53 -66.0, -19.57 APE12-dist-na 13.114 APE11-dist-na 12.5149 APE10-dist-na 13.1953 APE9-dist-in 7.9536 None PTR1007 PTR1007 XRAY 2.2 0.2 0.238 B 308.0 289.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnm TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: R5Y

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6VNMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 6VNMA O60674 840 1132 1132.0 R5Y:61201 Type1 Inactive DFGin 6.2756 13.8556 ABAminus -161.76, 45.15 -147.28, 91.94 -100.3, 24.04 301.04, 88.04 -66.18, -22.04 in-in in 8.4455 Saltbr-in 2.7946 HRD-in -70.38, -47.67 75.09, -3.21 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.31, 147.1 APE9-dihe-in -133.78, 127.05 APE8-dihe-in -79.36, 82.18 APE8-rot-na 30.27 APE67-dihe-in -79.86, -2.09 -63.93, -27.28 APE12-dist-na 13.1602 APE11-dist-na 9.3366 APE10-dist-na 9.9005 APE9-dist-in 7.0784 None PTR1007 PTR1007 XRAY 2.2 0.2 0.238 A 308.0 293.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnm Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 6VNMB O60674 843 1131 1132.0 R5Y:61201 Type1 Inactive DFGin 6.1813 13.7293 ABAminus -117.34, 7.17 -155.1, 140.98 -137.24, 30.83 296.86, 88.07 -64.53, -27.32 in-in in 8.4978 Saltbr-in 2.6668 HRD-in -72.3, -46.39 69.83, 0.54 in-in-in SNCiii in-in ActLoopNT-in 2.8402 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.62, 127.37 APE9-dihe-in -107.62, 146.18 APE8-dihe-in -72.44, 70.75 APE8-rot-na 28.98 APE67-dihe-in -82.72, -2.53 -66.0, -19.57 APE12-dist-na 13.114 APE11-dist-na 12.5149 APE10-dist-na 13.1953 APE9-dist-in 7.9536 None PTR1007 PTR1007 XRAY 2.2 0.2 0.238 B 308.0 289.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 6vnm Homo sapiens TYR_JAK2-2_HUMAN TYR 2.9e-87 298.2 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: R5Y

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name