Ligand: PY1

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 1PY5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL TGFBR1 TGFR1_HUMAN 1PY5A P36897 200 500 503.0 PY1:700 Type1 Inactive DFGin 6.3254 13.0957 BLAminus -139.22, -176.23 51.49, 62.68 -91.32, 17.81 306.9, 168.43 -57.65, -31.73 in-in in 7.8314 Saltbr-in 2.8966 HRD-in -74.07, -48.58 75.5, -7.56 in-in-out SNCiio in-out ActLoopNT-in 2.8618 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.55, -147.04 APE9-dihe-na -97.21, -166.02 APE8-dihe-in -77.65, 124.21 APE8-rot-in 307.07 APE67-dihe-in -64.31, -27.94 -63.63, -30.26 APE12-dist-in 11.444 APE11-dist-in 8.66 APE10-dist-out 8.5722 APE9-dist-in 4.1185 None None None XRAY 2.3 0.26 0.292 A 326.0 301.0 0 32 32 0 [[205, 494]] 1.0 1py5 TKL_TGFBR1_HUMAN TKL 4.1e-85 291.4 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1

Ligand: PY1

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 9NZKA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 YCK2 A0A8H6C375_CANAX 9NZKA A0A8H6C375 37 342 491.0 PY1:401 Type1 Active DFGin 6.6671 14.6317 BLAminus -123.53, -176.7 59.46, 85.99 -101.23, 22.92 290.97, 94.84 -64.24, -26.89 in-in in 7.9821 Saltbr-in 3.0316 HRD-in -91.37, -46.29 68.89, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.7743 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.37, 131.27 APE9-dihe-na 144.44, -170.54 APE8-dihe-in -103.59, 123.01 APE8-rot-in 303.79 APE67-dihe-in -60.54, -33.91 -64.0, -33.14 APE12-dist-in 11.6694 APE11-dist-in 13.3173 APE10-dist-in 7.536 APE9-dist-in 4.5206 None None None XRAY 1.7 0.176 0.211 A 309.0 306.0 0 35 35 0 [[44, 312]] 1.0 9nzk Candida albicans CK1_YCK2_CANAX CK1 4.4e-95 324.0 1.0 260.0 260.0 185 186 187 189 191 73 87 91 160 162 161 163.0 232 220 215 214 213 212 211 210 209 118 non-specific serine/threonine protein kinase
TKL TGFBR1 TGFR1_HUMAN 1PY5A P36897 200 500 503.0 PY1:700 Type1 Inactive DFGin 6.3254 13.0957 BLAminus -139.22, -176.23 51.49, 62.68 -91.32, 17.81 306.9, 168.43 -57.65, -31.73 in-in in 7.8314 Saltbr-in 2.8966 HRD-in -74.07, -48.58 75.5, -7.56 in-in-out SNCiio in-out ActLoopNT-in 2.8618 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.55, -147.04 APE9-dihe-na -97.21, -166.02 APE8-dihe-in -77.65, 124.21 APE8-rot-in 307.07 APE67-dihe-in -64.31, -27.94 -63.63, -30.26 APE12-dist-in 11.444 APE11-dist-in 8.66 APE10-dist-out 8.5722 APE9-dist-in 4.1185 None None None XRAY 2.3 0.26 0.292 A 326.0 301.0 0 32 32 0 [[205, 494]] 1.0 1py5 Homo sapiens TKL_TGFBR1_HUMAN TKL 4.1e-85 291.4 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1

Ligand: PY1

Total number of chains: 1
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 9NZKA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 YCK2 A0A8H6C375_CANAX 9NZKA A0A8H6C375 37 342 491.0 PY1:401 Type1 Active DFGin 6.6671 14.6317 BLAminus -123.53, -176.7 59.46, 85.99 -101.23, 22.92 290.97, 94.84 -64.24, -26.89 in-in in 7.9821 Saltbr-in 3.0316 HRD-in -91.37, -46.29 68.89, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.7743 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -74.37, 131.27 APE9-dihe-na 144.44, -170.54 APE8-dihe-in -103.59, 123.01 APE8-rot-in 303.79 APE67-dihe-in -60.54, -33.91 -64.0, -33.14 APE12-dist-in 11.6694 APE11-dist-in 13.3173 APE10-dist-in 7.536 APE9-dist-in 4.5206 None None None XRAY 1.7 0.176 0.211 A 309.0 306.0 0 35 35 0 [[44, 312]] 1.0 9nzk Candida albicans CK1_YCK2_CANAX CK1 4.4e-95 324.0 1.0 260.0 260.0 185 186 187 189 191 73 87 91 160 162 161 163.0 232 220 215 214 213 212 211 210 209 118 non-specific serine/threonine protein kinase