Ligand: LEV (Lenvatinib, Lenvima)

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 100.0% 5ZV2A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FGFR1 FGFR1_HUMAN 5ZV2A P11362 463 762 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.568 14.144 BLBplus -131.08, 166.37 55.4, 22.07 -76.03, 127.13 51.59, 83.66 103.79, -116.47 in-in in 7.858 Saltbr-in 3.143 HRD-in -69.2, -53.37 81.07, -9.59 in-out-out SNCioo out-out ActLoopNT-out 9.185 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -156.95, 137.73 APE9-dihe-in -102.4, 101.23 APE8-dihe-out -65.35, -22.62 APE8-rot-na 30.52 APE67-dihe-in -64.41, -13.08 -61.44, -25.69 APE12-dist-na 18.712 APE11-dist-na 21.068 APE10-dist-na 17.839 APE9-dist-out 12.103 C488A None None XRAY 2.86 0.215 0.269 A 305 284 16 0 0 2 [[478, 756]] 1.0 5zv2 TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5ZV2B P11362 461 764 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.735 13.333 BLBplus -131.99, 168.42 59.16, 17.33 -69.91, 121.62 49.14, 91.18 109.73, -109.09 in-in in 7.949 Saltbr-in 2.867 HRD-in -69.21, -53.97 80.59, -9.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioai APEdist_aaao APE10-dihe-none 999.0, 120.68 APE9-dihe-in -90.2, 111.18 APE8-dihe-out -62.93, -18.78 APE8-rot-na 29.94 APE67-dihe-in -66.68, -14.01 -56.35, -27.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.926 APE9-dist-out 11.61 C488A None None XRAY 2.86 0.215 0.269 B 305 281 23 0 0 10 [[478, 756]] 1.0 5zv2 TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR KDR VGFR2_HUMAN 3WZDA P35968 820 1167 1356.0 LEV:1201 Type1 Inactive DFGin 5.426 13.803 BLBplus -131.31, 171.12 64.88, 24.46 -69.96, 136.97 45.36, 91.24 79.76, 6.08 in-in in 7.309 Saltbr-in 2.943 HRD-in -65.52, -53.13 82.13, -20.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -70.62 APE8-dihe-out -53.22, -31.36 APE8-rot-na 22.8 APE67-dihe-in -66.02, -15.12 -58.21, -29.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.248 T940V None None XRAY 1.57 0.184 0.212 A 309 278 20 0 0 16 [[834, 1162]] 1.0 3wzd TYR_KDR_HUMAN TYR 3.7e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2

Ligand: LEV (Lenvatinib, Lenvima)

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 100.0% 5ZV2A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR FGFR1 FGFR1_HUMAN 5ZV2A P11362 463 762 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.568 14.144 BLBplus -131.08, 166.37 55.4, 22.07 -76.03, 127.13 51.59, 83.66 103.79, -116.47 in-in in 7.858 Saltbr-in 3.143 HRD-in -69.2, -53.37 81.07, -9.59 in-out-out SNCioo out-out ActLoopNT-out 9.185 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -156.95, 137.73 APE9-dihe-in -102.4, 101.23 APE8-dihe-out -65.35, -22.62 APE8-rot-na 30.52 APE67-dihe-in -64.41, -13.08 -61.44, -25.69 APE12-dist-na 18.712 APE11-dist-na 21.068 APE10-dist-na 17.839 APE9-dist-out 12.103 C488A None None XRAY 2.86 0.215 0.269 A 305 284 16 0 0 2 [[478, 756]] 1.0 5zv2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5ZV2B P11362 461 764 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.735 13.333 BLBplus -131.99, 168.42 59.16, 17.33 -69.91, 121.62 49.14, 91.18 109.73, -109.09 in-in in 7.949 Saltbr-in 2.867 HRD-in -69.21, -53.97 80.59, -9.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioai APEdist_aaao APE10-dihe-none 999.0, 120.68 APE9-dihe-in -90.2, 111.18 APE8-dihe-out -62.93, -18.78 APE8-rot-na 29.94 APE67-dihe-in -66.68, -14.01 -56.35, -27.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.926 APE9-dist-out 11.61 C488A None None XRAY 2.86 0.215 0.269 B 305 281 23 0 0 10 [[478, 756]] 1.0 5zv2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR KDR VGFR2_HUMAN 3WZDA P35968 820 1167 1356.0 LEV:1201 Type1 Inactive DFGin 5.426 13.803 BLBplus -131.31, 171.12 64.88, 24.46 -69.96, 136.97 45.36, 91.24 79.76, 6.08 in-in in 7.309 Saltbr-in 2.943 HRD-in -65.52, -53.13 82.13, -20.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -70.62 APE8-dihe-out -53.22, -31.36 APE8-rot-na 22.8 APE67-dihe-in -66.02, -15.12 -58.21, -29.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.248 T940V None None XRAY 1.57 0.184 0.212 A 309 278 20 0 0 16 [[834, 1162]] 1.0 3wzd Homo sapiens TYR_KDR_HUMAN TYR 3.7e-100 340.4 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2

Ligand: LEV (Lenvatinib, Lenvima)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name