Ligand: LCI

Total number of chains: 4
Active chains: 3
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6GZMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 CSNK1A1 KC1A_HUMAN 6GZDA P48729 9 305 337.0 LCI:1018 Type1 Active DFGin 6.7019 14.844 BLAminus -131.55, 177.32 70.46, 86.44 -102.55, 22.91 293.61, 98.06 -62.66, -35.34 in-in in 8.0957 Saltbr-in 3.1314 HRD-in -82.14, -48.34 69.83, 12.74 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.35, -32.42 APE9-dihe-na -87.44, -150.21 APE8-dihe-in -91.1, 131.82 APE8-rot-in 300.27 APE67-dihe-in -60.82, -38.86 -68.26, -34.55 APE12-dist-in 11.6581 APE11-dist-in 11.9492 APE10-dist-in 6.2789 APE9-dist-in 3.6388 None None None XRAY 2.28 0.177 0.221 A 374.0 297.0 0 35 35 0 [[17, 283]] 1.0 6gzd CK1_CSNK1A1_HUMAN CK1 6.2e-122 412.0 1.0 261.0 261.0 156 157 158 160 162 46 60 64 133 135 134 136.0 203 191 186 185 184 183 182 181 180 91 Casein kinase I isoform alpha
CK1 CSNK1D KC1D_HUMAN 6GZMA P48730 5 295 415.0 LCI:1004 Type1 Inactive DFGin 6.0917 14.8975 BLAminus -124.32, 164.33 79.67, 96.2 -103.0, 21.73 291.46, 97.37 -70.61, -17.22 in-in in 7.9922 Saltbr-in 3.0668 HRD-in -80.76, -48.3 70.22, 11.09 in-in-out SNCiio in-out ActLoopNT-in 2.8923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.57, -30.36 APE9-dihe-na -78.6, -147.37 APE8-dihe-in -125.32, 169.57 APE8-rot-out 191.56 APE67-dihe-in -53.28, -42.94 -88.52, -29.67 APE12-dist-in 13.5572 APE11-dist-in 12.3198 APE10-dist-in 6.9691 APE9-dist-in 4.5573 R13N None None XRAY 1.59 0.192 0.25 A 295.0 291.0 0 35 35 0 [[9, 275]] 1.0 6gzm CK1_CSNK1D_HUMAN CK1 3.8e-122 412.6 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6GZMB P48730 1 295 415.0 LCI:1003 Type1 Active DFGin 6.0286 14.94 BLAminus -133.71, 166.42 75.71, 96.43 -105.56, 19.57 289.87, 100.18 -66.61, -26.34 in-in in 8.2002 Saltbr-in 2.9776 HRD-in -81.5, -50.17 76.38, 3.88 in-in-in SNCiii in-in ActLoopNT-in 2.8849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.67, 144.06 APE9-dihe-na 111.45, -147.04 APE8-dihe-in -123.08, 119.05 APE8-rot-in 301.33 APE67-dihe-in -54.27, -40.27 -57.58, -37.53 APE12-dist-in 11.5776 APE11-dist-in 12.5318 APE10-dist-in 6.4674 APE9-dist-in 3.9807 R13N None None XRAY 1.59 0.192 0.25 B 295.0 295.0 0 35 35 0 [[9, 275]] 1.0 6gzm CK1_CSNK1D_HUMAN CK1 3.8e-122 412.6 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CDK9 CDK9_HUMAN 6GZHA P50750 8 326 372.0 LCI:2001 Type1 Active DFGin 6.9623 15.2757 BLAminus -143.64, 171.3 50.95, 83.68 -93.37, 33.37 284.73, 74.17 -64.71, -41.34 in-in in 9.6453 Saltbr-in 2.8862 HRD-in -65.68, -54.2 64.63, 22.42 in-in-in SNCiii in-in ActLoopNT-in 2.7717 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.77, 163.06 APE9-dihe-na 70.11, 142.16 APE8-dihe-in -60.75, 137.92 APE8-rot-in 300.9 APE67-dihe-in -63.71, -23.63 -48.56, -44.41 APE12-dist-in 12.8286 APE11-dist-in 10.3059 APE10-dist-in 6.5798 APE9-dist-in 3.427 None TPO186 TPO186 XRAY 3.17 0.175 0.257 A 326.0 310.0 9 32 29 3 [[19, 315]] 1.0 6gzh CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9

Ligand: LCI

Total number of chains: 4
Active chains: 3
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6GZMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CK1 CSNK1A1 KC1A_HUMAN 6GZDA P48729 9 305 337.0 LCI:1018 Type1 Active DFGin 6.7019 14.844 BLAminus -131.55, 177.32 70.46, 86.44 -102.55, 22.91 293.61, 98.06 -62.66, -35.34 in-in in 8.0957 Saltbr-in 3.1314 HRD-in -82.14, -48.34 69.83, 12.74 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.35, -32.42 APE9-dihe-na -87.44, -150.21 APE8-dihe-in -91.1, 131.82 APE8-rot-in 300.27 APE67-dihe-in -60.82, -38.86 -68.26, -34.55 APE12-dist-in 11.6581 APE11-dist-in 11.9492 APE10-dist-in 6.2789 APE9-dist-in 3.6388 None None None XRAY 2.28 0.177 0.221 A 374.0 297.0 0 35 35 0 [[17, 283]] 1.0 6gzd Homo sapiens CK1_CSNK1A1_HUMAN CK1 6.2e-122 412.0 1.0 261.0 261.0 156 157 158 160 162 46 60 64 133 135 134 136.0 203 191 186 185 184 183 182 181 180 91 Casein kinase I isoform alpha
CK1 CSNK1D KC1D_HUMAN 6GZMA P48730 5 295 415.0 LCI:1004 Type1 Inactive DFGin 6.0917 14.8975 BLAminus -124.32, 164.33 79.67, 96.2 -103.0, 21.73 291.46, 97.37 -70.61, -17.22 in-in in 7.9922 Saltbr-in 3.0668 HRD-in -80.76, -48.3 70.22, 11.09 in-in-out SNCiio in-out ActLoopNT-in 2.8923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -102.57, -30.36 APE9-dihe-na -78.6, -147.37 APE8-dihe-in -125.32, 169.57 APE8-rot-out 191.56 APE67-dihe-in -53.28, -42.94 -88.52, -29.67 APE12-dist-in 13.5572 APE11-dist-in 12.3198 APE10-dist-in 6.9691 APE9-dist-in 4.5573 R13N None None XRAY 1.59 0.192 0.25 A 295.0 291.0 0 35 35 0 [[9, 275]] 1.0 6gzm Homo sapiens CK1_CSNK1D_HUMAN CK1 3.8e-122 412.6 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6GZMB P48730 1 295 415.0 LCI:1003 Type1 Active DFGin 6.0286 14.94 BLAminus -133.71, 166.42 75.71, 96.43 -105.56, 19.57 289.87, 100.18 -66.61, -26.34 in-in in 8.2002 Saltbr-in 2.9776 HRD-in -81.5, -50.17 76.38, 3.88 in-in-in SNCiii in-in ActLoopNT-in 2.8849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.67, 144.06 APE9-dihe-na 111.45, -147.04 APE8-dihe-in -123.08, 119.05 APE8-rot-in 301.33 APE67-dihe-in -54.27, -40.27 -57.58, -37.53 APE12-dist-in 11.5776 APE11-dist-in 12.5318 APE10-dist-in 6.4674 APE9-dist-in 3.9807 R13N None None XRAY 1.59 0.192 0.25 B 295.0 295.0 0 35 35 0 [[9, 275]] 1.0 6gzm Homo sapiens CK1_CSNK1D_HUMAN CK1 3.8e-122 412.6 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC CDK9 CDK9_HUMAN 6GZHA P50750 8 326 372.0 LCI:2001 Type1 Active DFGin 6.9623 15.2757 BLAminus -143.64, 171.3 50.95, 83.68 -93.37, 33.37 284.73, 74.17 -64.71, -41.34 in-in in 9.6453 Saltbr-in 2.8862 HRD-in -65.68, -54.2 64.63, 22.42 in-in-in SNCiii in-in ActLoopNT-in 2.7717 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.77, 163.06 APE9-dihe-na 70.11, 142.16 APE8-dihe-in -60.75, 137.92 APE8-rot-in 300.9 APE67-dihe-in -63.71, -23.63 -48.56, -44.41 APE12-dist-in 12.8286 APE11-dist-in 10.3059 APE10-dist-in 6.5798 APE9-dist-in 3.427 None TPO186 TPO186 XRAY 3.17 0.175 0.257 A 326.0 310.0 9 32 29 3 [[19, 315]] 1.0 6gzh Homo sapiens CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9

Ligand: LCI

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name