Ligand: KR8

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6S1IA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6S1IA Q13627 135 481 763.0 KR8:503 Type1 Active DFGin 6.898 14.588 BLAminus -126.45, 178.1 62.9, 78.82 -94.61, 26.34 284.66, 74.88 -61.34, -34.33 in-in in 8.697 Saltbr-in 2.792 HRD-in -63.27, -44.28 74.47, -2.25 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.45, 164.14 APE9-dihe-na 77.6, 145.17 APE8-dihe-in -67.72, 141.59 APE8-rot-in 292.76 APE67-dihe-in -56.98, -28.19 -56.25, -45.01 APE12-dist-in 12.54 APE11-dist-in 11.114 APE10-dist-in 6.989 APE9-dist-in 3.126 None PTR321 PTR321 XRAY 2.38 0.202 0.228 A 361 347 0 0 0 0 [[159, 479]] 1.0 6s1i CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6S1IB Q13627 135 481 763.0 KR8:505 Type1 Active DFGin 6.965 14.548 BLAminus -125.09, 179.13 61.73, 80.78 -98.89, 25.32 290.26, 72.62 -61.57, -38.18 in-in in 8.772 Saltbr-in 2.834 HRD-in -65.26, -46.98 75.17, -0.72 in-in-in SNCiii in-in ActLoopNT-in 2.741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.9, 162.85 APE9-dihe-na 78.18, 146.19 APE8-dihe-in -67.03, 141.99 APE8-rot-in 283.82 APE67-dihe-in -57.88, -29.55 -55.88, -45.14 APE12-dist-in 12.921 APE11-dist-in 11.64 APE10-dist-in 7.231 APE9-dist-in 3.076 None PTR321 PTR321 XRAY 2.38 0.202 0.228 B 361 346 1 0 0 0 [[159, 479]] 1.0 6s1i CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6S1IC Q13627 135 481 763.0 KR8:505 Type1 Active DFGin 6.883 14.386 BLAminus -125.8, 178.51 61.15, 80.81 -97.76, 24.92 289.88, 75.99 -62.3, -32.74 in-in in 8.686 Saltbr-in 2.628 HRD-in -64.62, -43.93 75.06, -0.23 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.77, 158.73 APE9-dihe-na 76.8, 143.9 APE8-dihe-in -70.32, 140.69 APE8-rot-in 292.97 APE67-dihe-in -57.82, -29.55 -55.13, -45.7 APE12-dist-in 12.064 APE11-dist-in 10.094 APE10-dist-in 6.727 APE9-dist-in 3.071 None PTR321 PTR321 XRAY 2.38 0.202 0.228 C 361 345 2 0 0 1 [[159, 479]] 1.0 6s1i CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6S1ID Q13627 135 481 763.0 KR8:503 Type1 Active DFGin 6.958 14.617 BLAminus -125.25, 179.89 61.35, 78.92 -97.88, 24.63 284.55, 81.3 -62.38, -32.93 in-in in 8.646 Saltbr-in 2.758 HRD-in -63.56, -43.98 75.67, -1.81 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.5, 163.63 APE9-dihe-na 78.26, 147.78 APE8-dihe-in -66.75, 142.12 APE8-rot-in 283.64 APE67-dihe-in -57.25, -28.8 -57.5, -45.09 APE12-dist-in 13.463 APE11-dist-in 12.008 APE10-dist-in 7.185 APE9-dist-in 3.177 None PTR321 PTR321 XRAY 2.38 0.202 0.228 D 361 346 1 0 0 1 [[159, 479]] 1.0 6s1i CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: KR8

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6S1IA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC DYRK1A DYR1A_HUMAN 6S1IA Q13627 135 481 763.0 KR8:503 Type1 Active DFGin 6.898 14.588 BLAminus -126.45, 178.1 62.9, 78.82 -94.61, 26.34 284.66, 74.88 -61.34, -34.33 in-in in 8.697 Saltbr-in 2.792 HRD-in -63.27, -44.28 74.47, -2.25 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.45, 164.14 APE9-dihe-na 77.6, 145.17 APE8-dihe-in -67.72, 141.59 APE8-rot-in 292.76 APE67-dihe-in -56.98, -28.19 -56.25, -45.01 APE12-dist-in 12.54 APE11-dist-in 11.114 APE10-dist-in 6.989 APE9-dist-in 3.126 None PTR321 PTR321 XRAY 2.38 0.202 0.228 A 361 347 0 0 0 0 [[159, 479]] 1.0 6s1i Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6S1IB Q13627 135 481 763.0 KR8:505 Type1 Active DFGin 6.965 14.548 BLAminus -125.09, 179.13 61.73, 80.78 -98.89, 25.32 290.26, 72.62 -61.57, -38.18 in-in in 8.772 Saltbr-in 2.834 HRD-in -65.26, -46.98 75.17, -0.72 in-in-in SNCiii in-in ActLoopNT-in 2.741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.9, 162.85 APE9-dihe-na 78.18, 146.19 APE8-dihe-in -67.03, 141.99 APE8-rot-in 283.82 APE67-dihe-in -57.88, -29.55 -55.88, -45.14 APE12-dist-in 12.921 APE11-dist-in 11.64 APE10-dist-in 7.231 APE9-dist-in 3.076 None PTR321 PTR321 XRAY 2.38 0.202 0.228 B 361 346 1 0 0 0 [[159, 479]] 1.0 6s1i Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6S1IC Q13627 135 481 763.0 KR8:505 Type1 Active DFGin 6.883 14.386 BLAminus -125.8, 178.51 61.15, 80.81 -97.76, 24.92 289.88, 75.99 -62.3, -32.74 in-in in 8.686 Saltbr-in 2.628 HRD-in -64.62, -43.93 75.06, -0.23 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.77, 158.73 APE9-dihe-na 76.8, 143.9 APE8-dihe-in -70.32, 140.69 APE8-rot-in 292.97 APE67-dihe-in -57.82, -29.55 -55.13, -45.7 APE12-dist-in 12.064 APE11-dist-in 10.094 APE10-dist-in 6.727 APE9-dist-in 3.071 None PTR321 PTR321 XRAY 2.38 0.202 0.228 C 361 345 2 0 0 1 [[159, 479]] 1.0 6s1i Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 6S1ID Q13627 135 481 763.0 KR8:503 Type1 Active DFGin 6.958 14.617 BLAminus -125.25, 179.89 61.35, 78.92 -97.88, 24.63 284.55, 81.3 -62.38, -32.93 in-in in 8.646 Saltbr-in 2.758 HRD-in -63.56, -43.98 75.67, -1.81 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -100.5, 163.63 APE9-dihe-na 78.26, 147.78 APE8-dihe-in -66.75, 142.12 APE8-rot-in 283.64 APE67-dihe-in -57.25, -28.8 -57.5, -45.09 APE12-dist-in 13.463 APE11-dist-in 12.008 APE10-dist-in 7.185 APE9-dist-in 3.177 None PTR321 PTR321 XRAY 2.38 0.202 0.228 D 361 346 1 0 0 1 [[159, 479]] 1.0 6s1i Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.4e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: KR8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name