Ligand: KEV

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6N7AB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK1-2 JAK1_HUMAN 6N7AA P23458 865 1154 1154.0 KEV:61203 Type1 Inactive DFGin 6.4526 13.3666 ABAminus -116.98, 9.47 -160.4, 147.32 -135.39, 27.13 297.85, 83.25 -58.95, -23.42 in-in in 7.7452 Saltbr-in 2.7564 HRD-in -75.17, -44.67 72.8, -4.01 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.07, 124.84 APE9-dihe-in -104.44, 150.91 APE8-dihe-in -83.53, 72.06 APE8-rot-na 34.1 APE67-dihe-in -76.43, -2.54 -56.05, -29.88 APE12-dist-na 14.6585 APE11-dist-na 9.2784 APE10-dist-na 12.111 APE9-dist-in 7.138 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.33 0.192 0.207 A 304.0 278.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7a TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 6N7AB P23458 854 1154 1154.0 KEV:61202 Type1 Inactive DFGin 6.4703 13.4982 ABAminus -116.23, 10.2 -162.11, 148.53 -137.01, 27.49 296.62, 85.6 -60.22, -22.88 in-in in 7.7761 Saltbr-in 2.7552 HRD-in -73.34, -48.05 70.64, 1.99 in-in-in SNCiii in-in ActLoopNT-in 2.8043 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.78, 65.84 APE9-dihe-in -92.65, 132.46 APE8-dihe-in -84.19, 73.36 APE8-rot-na 33.1 APE67-dihe-in -76.82, -1.21 -55.1, -31.23 APE12-dist-na 10.789 APE11-dist-na 11.6888 APE10-dist-na 9.266 APE9-dist-in 6.8188 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.33 0.192 0.207 B 304.0 291.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7a TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1

Ligand: KEV

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6N7AB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK1-2 JAK1_HUMAN 6N7AA P23458 865 1154 1154.0 KEV:61203 Type1 Inactive DFGin 6.4526 13.3666 ABAminus -116.98, 9.47 -160.4, 147.32 -135.39, 27.13 297.85, 83.25 -58.95, -23.42 in-in in 7.7452 Saltbr-in 2.7564 HRD-in -75.17, -44.67 72.8, -4.01 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.07, 124.84 APE9-dihe-in -104.44, 150.91 APE8-dihe-in -83.53, 72.06 APE8-rot-na 34.1 APE67-dihe-in -76.43, -2.54 -56.05, -29.88 APE12-dist-na 14.6585 APE11-dist-na 9.2784 APE10-dist-na 12.111 APE9-dist-in 7.138 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.33 0.192 0.207 A 304.0 278.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7a Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 6N7AB P23458 854 1154 1154.0 KEV:61202 Type1 Inactive DFGin 6.4703 13.4982 ABAminus -116.23, 10.2 -162.11, 148.53 -137.01, 27.49 296.62, 85.6 -60.22, -22.88 in-in in 7.7761 Saltbr-in 2.7552 HRD-in -73.34, -48.05 70.64, 1.99 in-in-in SNCiii in-in ActLoopNT-in 2.8043 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.78, 65.84 APE9-dihe-in -92.65, 132.46 APE8-dihe-in -84.19, 73.36 APE8-rot-na 33.1 APE67-dihe-in -76.82, -1.21 -55.1, -31.23 APE12-dist-na 10.789 APE11-dist-na 11.6888 APE10-dist-na 9.266 APE9-dist-in 6.8188 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.33 0.192 0.207 B 304.0 291.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7a Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1

Ligand: KEV

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name