Ligand: JX4

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6MOMD
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 6MOMA Q9NWZ3 164 460 460.0 JX4:500 Type1 Active DFGin 7.129 13.342 BLAminus -133.95, 172.65 70.74, 82.36 -107.03, 19.92 305.8, 92.98 -64.41, -27.6 in-in in 8.255 Saltbr-in 3.009 HRD-in -79.36, -51.43 75.47, 2.41 in-in-in SNCiii in-in ActLoopNT-in 2.713 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.06, 152.26 APE9-dihe-na 137.43, -179.57 APE8-dihe-in -101.68, 120.01 APE8-rot-in 303.6 APE67-dihe-in -63.77, -14.43 -53.86, -42.85 APE12-dist-in 10.343 APE11-dist-in 12.139 APE10-dist-in 7.302 APE9-dist-in 4.791 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 A 303 289 8 0 0 3 [[183, 456]] 1.0 6mom TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6MOMB Q9NWZ3 164 459 460.0 JX4:500 Type1 Inactive DFGin 7.165 13.515 BLAminus -127.54, 170.46 71.09, 82.13 -106.22, 20.82 305.71, 89.03 -65.5, -27.27 in-out in 8.549 Saltbr-out 5.088 HRD-in -79.93, -51.42 76.22, 2.24 out-in-in SNCoii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 152.75 APE9-dihe-na 140.22, 179.97 APE8-dihe-in -102.97, 112.18 APE8-rot-in 307.34 APE67-dihe-in -63.75, -15.14 -58.52, -34.89 APE12-dist-in 10.13 APE11-dist-in 12.031 APE10-dist-in 7.01 APE9-dist-in 4.562 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 B 303 289 7 0 0 4 [[183, 456]] 1.0 6mom TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6MOMC Q9NWZ3 163 460 460.0 JX4:500 Type1 Active DFGin 7.132 13.33 BLAminus -133.27, 172.2 69.98, 81.72 -106.08, 16.49 303.99, 96.21 -63.79, -25.79 in-in in 8.237 Saltbr-in 2.78 HRD-in -77.9, -50.77 76.54, 1.38 in-in-in SNCiii in-in ActLoopNT-in 2.717 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 151.25 APE9-dihe-na 135.21, -179.82 APE8-dihe-in -101.82, 118.78 APE8-rot-in 306.47 APE67-dihe-in -63.2, -15.41 -53.95, -41.15 APE12-dist-in 10.357 APE11-dist-in 12.07 APE10-dist-in 7.067 APE9-dist-in 4.647 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 C 303 292 6 0 0 3 [[183, 456]] 1.0 6mom TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6MOMD Q9NWZ3 164 459 460.0 JX4:500 Type1 Inactive DFGin 6.996 13.418 BLAminus -130.88, 172.79 70.38, 81.05 -105.81, 20.52 305.57, 94.51 -64.31, -26.67 in-out in 8.488 Saltbr-out 4.681 HRD-in -80.85, -51.58 75.47, 1.68 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.31, 153.05 APE9-dihe-na 140.98, -178.81 APE8-dihe-in -101.12, 113.96 APE8-rot-in 309.17 APE67-dihe-in -64.74, -14.89 -58.96, -36.24 APE12-dist-in 10.151 APE11-dist-in 11.959 APE10-dist-in 7.042 APE9-dist-in 4.546 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 D 303 296 0 0 0 0 [[183, 456]] 1.0 6mom TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: JX4

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 6MOMD
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 6MOMA Q9NWZ3 164 460 460.0 JX4:500 Type1 Active DFGin 7.129 13.342 BLAminus -133.95, 172.65 70.74, 82.36 -107.03, 19.92 305.8, 92.98 -64.41, -27.6 in-in in 8.255 Saltbr-in 3.009 HRD-in -79.36, -51.43 75.47, 2.41 in-in-in SNCiii in-in ActLoopNT-in 2.713 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.06, 152.26 APE9-dihe-na 137.43, -179.57 APE8-dihe-in -101.68, 120.01 APE8-rot-in 303.6 APE67-dihe-in -63.77, -14.43 -53.86, -42.85 APE12-dist-in 10.343 APE11-dist-in 12.139 APE10-dist-in 7.302 APE9-dist-in 4.791 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 A 303 289 8 0 0 3 [[183, 456]] 1.0 6mom Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6MOMB Q9NWZ3 164 459 460.0 JX4:500 Type1 Inactive DFGin 7.165 13.515 BLAminus -127.54, 170.46 71.09, 82.13 -106.22, 20.82 305.71, 89.03 -65.5, -27.27 in-out in 8.549 Saltbr-out 5.088 HRD-in -79.93, -51.42 76.22, 2.24 out-in-in SNCoii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.82, 152.75 APE9-dihe-na 140.22, 179.97 APE8-dihe-in -102.97, 112.18 APE8-rot-in 307.34 APE67-dihe-in -63.75, -15.14 -58.52, -34.89 APE12-dist-in 10.13 APE11-dist-in 12.031 APE10-dist-in 7.01 APE9-dist-in 4.562 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 B 303 289 7 0 0 4 [[183, 456]] 1.0 6mom Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6MOMC Q9NWZ3 163 460 460.0 JX4:500 Type1 Active DFGin 7.132 13.33 BLAminus -133.27, 172.2 69.98, 81.72 -106.08, 16.49 303.99, 96.21 -63.79, -25.79 in-in in 8.237 Saltbr-in 2.78 HRD-in -77.9, -50.77 76.54, 1.38 in-in-in SNCiii in-in ActLoopNT-in 2.717 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.08, 151.25 APE9-dihe-na 135.21, -179.82 APE8-dihe-in -101.82, 118.78 APE8-rot-in 306.47 APE67-dihe-in -63.2, -15.41 -53.95, -41.15 APE12-dist-in 10.357 APE11-dist-in 12.07 APE10-dist-in 7.067 APE9-dist-in 4.647 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 C 303 292 6 0 0 3 [[183, 456]] 1.0 6mom Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6MOMD Q9NWZ3 164 459 460.0 JX4:500 Type1 Inactive DFGin 6.996 13.418 BLAminus -130.88, 172.79 70.38, 81.05 -105.81, 20.52 305.57, 94.51 -64.31, -26.67 in-out in 8.488 Saltbr-out 4.681 HRD-in -80.85, -51.58 75.47, 1.68 out-in-in SNCoii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.31, 153.05 APE9-dihe-na 140.98, -178.81 APE8-dihe-in -101.12, 113.96 APE8-rot-in 309.17 APE67-dihe-in -64.74, -14.89 -58.96, -36.24 APE12-dist-in 10.151 APE11-dist-in 11.959 APE10-dist-in 7.042 APE9-dist-in 4.546 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.1 0.168 0.207 D 303 296 0 0 0 0 [[183, 456]] 1.0 6mom Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: JX4

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name