Ligand: IYZ

Total number of chains: 4
Active chains: 3
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 9I17A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK PIM1 PIM1_HUMAN 2C3IB P11309 37 305 313.0 IYZ:1306 Type1 Active DFGin 6.326 14.753 BLAminus -127.31, 169.9 65.35, 81.96 -93.82, 15.98 286.0, 76.19 -64.86, -18.96 in-in in 8.592 Saltbr-in 2.708 HRD-na-A -73.6, -47.48 67.75, 10.67 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.67, 24.77 APE9-dihe-na -79.26, -156.38 APE8-dihe-in -92.5, 121.61 APE8-rot-in 301.77 APE67-dihe-in -67.73, -10.57 -57.93, -41.83 APE12-dist-in 9.52 APE11-dist-in 8.565 APE10-dist-in 5.327 APE9-dist-in 3.777 R250G None None XRAY 1.9 0.187 0.219 B 313 266 3 0 0 0 [[38, 290]] 1.0 2c3i CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC CLK1 CLK1_HUMAN 6YTAA P49759 148 483 484.0 IYZ:60702 Type1 Active DFGin 6.935 13.725 BLAminus -125.39, 175.02 66.16, 92.34 -102.15, 17.18 301.41, 98.15 -60.08, -20.3 in-in in 8.317 Saltbr-in 2.699 HRD-in -68.08, -57.05 83.09, -18.57 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.65, 155.94 APE9-dihe-na 83.67, 157.83 APE8-dihe-in -84.55, 129.06 APE8-rot-in 292.9 APE67-dihe-in -62.02, -24.22 -28.74, -53.35 APE12-dist-in 13.211 APE11-dist-in 11.663 APE10-dist-in 7.375 APE9-dist-in 3.159 None None None XRAY 2.3 0.194 0.275 A 339 336 0 0 0 0 [[161, 477]] 1.0 6yta CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CSNK2A1 CSK21_HUMAN 9I17A P68400 3 330 391.0 A1IYZ:403 Type1 Active DFGin 7.452 16.348 BLAminus -117.72, 179.15 59.1, 67.33 -83.54, 18.0 297.1, 81.44 -70.78, -18.84 in-in in 9.406 Saltbr-in 2.702 HRD-in -76.7, -47.42 68.51, 11.23 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.9, 170.73 APE9-dihe-na 61.8, 158.57 APE8-dihe-in -80.55, 152.4 APE8-rot-in 293.54 APE67-dihe-in -68.86, -13.66 -46.04, -51.2 APE12-dist-in 12.54 APE11-dist-in 10.249 APE10-dist-in 6.086 APE9-dist-in 3.263 None None None XRAY 1.55 0.165 0.192 A 328 328 0 0 0 0 [[39, 324]] 1.0 9i17 CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
TKL ACVR1 ACVR1_HUMAN 4DYMA Q04771 207 499 509.0 IYZ:503 Type1 Inactive DFGin 7.35 12.994 BLAminus -95.12, 171.56 68.54, 94.25 -112.58, 21.32 293.39, 167.99 -72.08, -14.94 in-out in 8.886 Saltbr-out 4.563 HRD-in -84.9, -47.48 69.85, 4.05 out-in-out SNCoio in-out ActLoopNT-in 2.964 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.83, 177.0 APE9-dihe-na -52.44, -173.58 APE8-dihe-in -89.42, 123.68 APE8-rot-in 308.16 APE67-dihe-in -62.72, -31.35 -61.06, -26.38 APE12-dist-in 10.743 APE11-dist-out 6.841 APE10-dist-out 9.124 APE9-dist-in 3.91 R206H None None XRAY 2.42 0.271 0.279 A 301 293 0 0 0 0 [[207, 497]] 1.0 4dym TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

Ligand: IYZ

Total number of chains: 4
Active chains: 3
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 9I17A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK PIM1 PIM1_HUMAN 2C3IB P11309 37 305 313.0 IYZ:1306 Type1 Active DFGin 6.326 14.753 BLAminus -127.31, 169.9 65.35, 81.96 -93.82, 15.98 286.0, 76.19 -64.86, -18.96 in-in in 8.592 Saltbr-in 2.708 HRD-na-A -73.6, -47.48 67.75, 10.67 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.67, 24.77 APE9-dihe-na -79.26, -156.38 APE8-dihe-in -92.5, 121.61 APE8-rot-in 301.77 APE67-dihe-in -67.73, -10.57 -57.93, -41.83 APE12-dist-in 9.52 APE11-dist-in 8.565 APE10-dist-in 5.327 APE9-dist-in 3.777 R250G None None XRAY 1.9 0.187 0.219 B 313 266 3 0 0 0 [[38, 290]] 1.0 2c3i Homo sapiens CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC CLK1 CLK1_HUMAN 6YTAA P49759 148 483 484.0 IYZ:60702 Type1 Active DFGin 6.935 13.725 BLAminus -125.39, 175.02 66.16, 92.34 -102.15, 17.18 301.41, 98.15 -60.08, -20.3 in-in in 8.317 Saltbr-in 2.699 HRD-in -68.08, -57.05 83.09, -18.57 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.65, 155.94 APE9-dihe-na 83.67, 157.83 APE8-dihe-in -84.55, 129.06 APE8-rot-in 292.9 APE67-dihe-in -62.02, -24.22 -28.74, -53.35 APE12-dist-in 13.211 APE11-dist-in 11.663 APE10-dist-in 7.375 APE9-dist-in 3.159 None None None XRAY 2.3 0.194 0.275 A 339 336 0 0 0 0 [[161, 477]] 1.0 6yta Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CSNK2A1 CSK21_HUMAN 9I17A P68400 3 330 391.0 A1IYZ:403 Type1 Active DFGin 7.452 16.348 BLAminus -117.72, 179.15 59.1, 67.33 -83.54, 18.0 297.1, 81.44 -70.78, -18.84 in-in in 9.406 Saltbr-in 2.702 HRD-in -76.7, -47.42 68.51, 11.23 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.9, 170.73 APE9-dihe-na 61.8, 158.57 APE8-dihe-in -80.55, 152.4 APE8-rot-in 293.54 APE67-dihe-in -68.86, -13.66 -46.04, -51.2 APE12-dist-in 12.54 APE11-dist-in 10.249 APE10-dist-in 6.086 APE9-dist-in 3.263 None None None XRAY 1.55 0.165 0.192 A 328 328 0 0 0 0 [[39, 324]] 1.0 9i17 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
TKL ACVR1 ACVR1_HUMAN 4DYMA Q04771 207 499 509.0 IYZ:503 Type1 Inactive DFGin 7.35 12.994 BLAminus -95.12, 171.56 68.54, 94.25 -112.58, 21.32 293.39, 167.99 -72.08, -14.94 in-out in 8.886 Saltbr-out 4.563 HRD-in -84.9, -47.48 69.85, 4.05 out-in-out SNCoio in-out ActLoopNT-in 2.964 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -117.83, 177.0 APE9-dihe-na -52.44, -173.58 APE8-dihe-in -89.42, 123.68 APE8-rot-in 308.16 APE67-dihe-in -62.72, -31.35 -61.06, -26.38 APE12-dist-in 10.743 APE11-dist-out 6.841 APE10-dist-out 9.124 APE9-dist-in 3.91 R206H None None XRAY 2.42 0.271 0.279 A 301 293 0 0 0 0 [[207, 497]] 1.0 4dym Homo sapiens TKL_ACVR1_HUMAN TKL 1.8e-85 292.7 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

Ligand: IYZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name