KinCore

Ligand: IH7

Total number of chains: 3

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAplus	3	100.0%	7YBXA

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	FGFR4	FGFR4_HUMAN	7YBXA	P22455	453	752	802.0	IH7:801	Type1	Inactive	DFGin	5.487	13.153	BLAplus	-117.55, 160.19	54.53, 49.02	-91.8, -26.59	44.5, 84.85	-106.57, 50.06	in-in	in	7.559	Saltbr-in	2.569	HRD-in	-80.18, -45.42	74.32, -9.85	in-out-out	SNCioo	out-out	ActLoopNT-out	8.685	ActLoopCT-out	TYR	APEdihe_iioai	APEdist_aaao	APE10-dihe-in	-80.48, 136.62	APE9-dihe-in	-109.39, 93.32	APE8-dihe-out	-58.06, -17.41	APE8-rot-na	334.8	APE67-dihe-in	-75.5, -1.38	-66.17, -23.12	APE12-dist-na	19.683	APE11-dist-na	21.389	APE10-dist-na	17.29	APE9-dist-out	11.925	V550M,R664E	None	None	XRAY	2.233	0.182	0.22	A	309	300	0	0	0	0	[[467, 745]]	1.0	7ybx	TYR_FGFR4_HUMAN	TYR	7e-101	342.8	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4
TYR	FGFR4	FGFR4_HUMAN	7YBPA	P22455	453	752	802.0	IH7:801	Type1	Inactive	DFGin	5.694	13.112	BLAplus	-118.3, 157.64	52.77, 54.66	-79.94, -64.81	29.11, 91.47	-101.86, 63.71	in-in	in	7.529	Saltbr-in	2.425	HRD-in	-81.24, -48.67	73.48, -6.26	in-out-out	SNCioo	out-out	ActLoopNT-out	8.825	ActLoopCT-out	TYR	APEdihe_iioai	APEdist_aaao	APE10-dihe-in	-81.22, 136.85	APE9-dihe-in	-109.57, 90.67	APE8-dihe-out	-55.15, -19.67	APE8-rot-na	333.84	APE67-dihe-in	-75.88, -4.09	-65.13, -21.92	APE12-dist-na	20.005	APE11-dist-na	21.526	APE10-dist-na	17.387	APE9-dist-out	11.892	V550L,R664E	None	None	XRAY	2.243	0.178	0.214	A	309	300	0	0	0	0	[[467, 745]]	1.0	7ybp	TYR_FGFR4_HUMAN	TYR	1.9e-100	341.4	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4
TYR	FGFR4	FGFR4_HUMAN	7YBOA	P22455	453	752	802.0	IH7:801	Type1	Inactive	DFGin	5.424	13.004	BLAplus	-109.16, 160.64	54.99, 45.18	-87.51, -29.93	42.89, 87.09	-102.4, 91.8	in-in	in	7.638	Saltbr-in	3.524	HRD-in	-80.44, -50.18	72.25, -3.15	in-out-out	SNCioo	out-out	ActLoopNT-out	8.547	ActLoopCT-out	TYR	APEdihe_iioai	APEdist_aaao	APE10-dihe-in	-92.41, 138.05	APE9-dihe-in	-107.71, 88.36	APE8-dihe-out	-54.72, -19.34	APE8-rot-na	336.83	APE67-dihe-in	-77.24, 0.55	-64.65, -24.27	APE12-dist-na	18.682	APE11-dist-na	20.466	APE10-dist-na	16.682	APE9-dist-out	11.546	R664E	None	None	XRAY	2.307	0.209	0.254	A	311	294	6	0	0	0	[[467, 745]]	1.0	7ybo	TYR_FGFR4_HUMAN	TYR	1.9e-100	341.4	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4

Ligand: IH7

Total number of chains: 3

Active chains: 0

Total number of genes: 1

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAplus	3	100.0%	7YBXA

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name
TYR	FGFR4	FGFR4_HUMAN	7YBXA	P22455	453	752	802.0	IH7:801	Type1	Inactive	DFGin	5.487	13.153	BLAplus	-117.55, 160.19	54.53, 49.02	-91.8, -26.59	44.5, 84.85	-106.57, 50.06	in-in	in	7.559	Saltbr-in	2.569	HRD-in	-80.18, -45.42	74.32, -9.85	in-out-out	SNCioo	out-out	ActLoopNT-out	8.685	ActLoopCT-out	TYR	APEdihe_iioai	APEdist_aaao	APE10-dihe-in	-80.48, 136.62	APE9-dihe-in	-109.39, 93.32	APE8-dihe-out	-58.06, -17.41	APE8-rot-na	334.8	APE67-dihe-in	-75.5, -1.38	-66.17, -23.12	APE12-dist-na	19.683	APE11-dist-na	21.389	APE10-dist-na	17.29	APE9-dist-out	11.925	V550M,R664E	None	None	XRAY	2.233	0.182	0.22	A	309	300	0	0	0	0	[[467, 745]]	1.0	7ybx	Homo sapiens	TYR_FGFR4_HUMAN	TYR	7e-101	342.8	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4
TYR	FGFR4	FGFR4_HUMAN	7YBPA	P22455	453	752	802.0	IH7:801	Type1	Inactive	DFGin	5.694	13.112	BLAplus	-118.3, 157.64	52.77, 54.66	-79.94, -64.81	29.11, 91.47	-101.86, 63.71	in-in	in	7.529	Saltbr-in	2.425	HRD-in	-81.24, -48.67	73.48, -6.26	in-out-out	SNCioo	out-out	ActLoopNT-out	8.825	ActLoopCT-out	TYR	APEdihe_iioai	APEdist_aaao	APE10-dihe-in	-81.22, 136.85	APE9-dihe-in	-109.57, 90.67	APE8-dihe-out	-55.15, -19.67	APE8-rot-na	333.84	APE67-dihe-in	-75.88, -4.09	-65.13, -21.92	APE12-dist-na	20.005	APE11-dist-na	21.526	APE10-dist-na	17.387	APE9-dist-out	11.892	V550L,R664E	None	None	XRAY	2.243	0.178	0.214	A	309	300	0	0	0	0	[[467, 745]]	1.0	7ybp	Homo sapiens	TYR_FGFR4_HUMAN	TYR	1.9e-100	341.4	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4
TYR	FGFR4	FGFR4_HUMAN	7YBOA	P22455	453	752	802.0	IH7:801	Type1	Inactive	DFGin	5.424	13.004	BLAplus	-109.16, 160.64	54.99, 45.18	-87.51, -29.93	42.89, 87.09	-102.4, 91.8	in-in	in	7.638	Saltbr-in	3.524	HRD-in	-80.44, -50.18	72.25, -3.15	in-out-out	SNCioo	out-out	ActLoopNT-out	8.547	ActLoopCT-out	TYR	APEdihe_iioai	APEdist_aaao	APE10-dihe-in	-92.41, 138.05	APE9-dihe-in	-107.71, 88.36	APE8-dihe-out	-54.72, -19.34	APE8-rot-na	336.83	APE67-dihe-in	-77.24, 0.55	-64.65, -24.27	APE12-dist-na	18.682	APE11-dist-na	20.466	APE10-dist-na	16.682	APE9-dist-out	11.546	R664E	None	None	XRAY	2.307	0.209	0.254	A	311	294	6	0	0	0	[[467, 745]]	1.0	7ybo	Homo sapiens	TYR_FGFR4_HUMAN	TYR	1.9e-100	341.4	1	261	261	629	630	631	633	635	503	520	524	609	611	610	612	671	659	654	653	652	651	650	649	648	551	Fibroblast growth factor receptor 4

Ligand: IH7

Total number of chains: 0

Active chains: 0

Total number of genes: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative

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Group	Gene	SwissprotID	PDB	UniprotID	First_obs_res	Last_obs_res	Length_Unp	Ligand	Ligand_type	Activity_label	Spatial_label	Phe_Glu4_dis	Phe_Lys_dis	Dihedral_label	XDFG φ,ψ	DFG-Asp φ,ψ	DFG-Phe φ,ψ	DFG-Phe χ1,χ2	DFG-Gly φ,ψ	ChelixSaltbr_label	Chelix_label	Lys_Glu_dis	Saltbr_label	LysNZ_GluOE_dis	HRD_label	His φ,ψ	Arg φ,ψ	SNC_label	SNCpymol_label	ActLoop_label	ActLoopNT_label	DFG6_XHRD_dis	ActLoopCT_label	APEtype	APEdihe_label	APEdist_label	APE10_dihe_label	APE10 φ,ψ	APE9_dihe_label	APE9 φ,ψ	APE8_dihe_label	APE8 φ,ψ	APE8_rotamer_label	APE8 χ1	APE67_label	APE6 φ,ψ	APE7 φ,ψ	APE12_dist_label	APE12_DFG4_dis	APE11_dist_label	APE11_DFG4_dis	APE10_dist_label	APE10_DFG4_dis	APE9_dist_label	APE9_Arg_dis	Chain_mut	Chain_phos	Modified_aa	Method	Resolution	Rvalue	FreeRvalue	Chain_id	ChainLen	Ordered_residues	DomainBreak	ActLoopLength	ActLoopResolvedResidues	ActLoopDisorderedResidues	Kinase_domains_Unp	N_Kinase_domains_Unp	pdb	Species	Kincore_name	hmm	Evalue	Score	hmmbeg	hmmend	hmmlen	XDFGnum	DFGnum	PHEnum	DFG4num	DFG6num	LYSnum	GLUnum	GLU4num	XHRDnum	ARGnum	HRDnum	HRDaspnum	aFaspnum	APEnum	APE6num	APE7num	APE8num	APE9num	APE10num	APE11num	APE12num	Hinge1num	Protein_name