Ligand: HEW

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 9ET9A
None None 1 33.3% 6Q3FA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ET9A P24941 1 297 298.0 HEW:60801,HEW:60802,HEW:60803,HEW:60804,HEW:60805 Allosteric,Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.5721 15.4086 BLAminus -133.96, -177.38 53.45, 84.64 -98.13, 25.94 274.26, 70.21 -74.85, -27.45 in-in in 8.7348 Saltbr-in 3.0588 HRD-in -78.44, -57.38 73.64, 19.34 in-in-in SNCiii in-in ActLoopNT-in 3.0402 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.56, 159.19 APE9-dihe-na 80.63, 125.87 APE8-dihe-in -49.88, 140.65 APE8-rot-in 303.1 APE67-dihe-in -56.41, -19.57 -59.45, -45.78 APE12-dist-in 12.8944 APE11-dist-in 11.8889 APE10-dist-in 7.2502 APE9-dist-in 3.3505 None TPO160 TPO160 XRAY 2.494 0.225 0.246 A 302.0 293.0 4 28 28 0 [[4, 286]] 1.0 9et9 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ET9C P24941 1 296 298.0 HEW:60701,HEW:60702 Type1,Allosteric Active DFGin 6.7768 15.3416 BLAminus -145.5, -178.18 52.74, 79.01 -102.36, 32.74 279.23, 71.65 -77.89, -27.55 in-in in 8.5303 Saltbr-in 3.1949 HRD-in -81.68, -55.92 73.5, 13.51 in-in-in SNCiii in-in ActLoopNT-in 2.8332 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.61, 143.17 APE9-dihe-na 75.3, 125.76 APE8-dihe-in -51.4, 141.63 APE8-rot-in 308.72 APE67-dihe-in -57.1, -22.45 -43.98, -53.09 APE12-dist-in 12.7008 APE11-dist-in 9.9902 APE10-dist-in 7.1499 APE9-dist-in 3.2787 None TPO160 TPO160 XRAY 2.494 0.225 0.246 C 302.0 286.0 10 28 28 0 [[4, 286]] 1.0 9et9 CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6Q3FA P24941 1 298 298.0 HEW:60301 Allosteric Inactive None 11.3609 18.4849 None -100.23, 146.03 76.96, 22.05 -56.57, 140.57 248.16, 89.95 83.91, -13.62 out-out out 15.3636 Saltbr-out 17.7399 HRD-in -87.95, -62.63 79.68, -15.73 out-out-out SNCooo out-out ActLoopNT-out 5.7342 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.97, 126.52 APE9-dihe-na -73.61, 124.69 APE8-dihe-in -63.01, 140.77 APE8-rot-out 188.63 APE67-dihe-in -61.19, -27.7 -97.02, -5.86 APE12-dist-out 20.2441 APE11-dist-out 17.6054 APE10-dist-out 18.9112 APE9-dist-out 10.2777 None None OCS177 XRAY 1.18 0.163 0.189 A 306.0 289.0 9 28 28 0 [[4, 286]] 1.0 6q3f CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: HEW

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 9ET9A
None None 1 33.3% 6Q3FA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 9ET9A P24941 1 297 298.0 HEW:60801,HEW:60802,HEW:60803,HEW:60804,HEW:60805 Allosteric,Type1,Allosteric,Allosteric,Allosteric Active DFGin 6.5721 15.4086 BLAminus -133.96, -177.38 53.45, 84.64 -98.13, 25.94 274.26, 70.21 -74.85, -27.45 in-in in 8.7348 Saltbr-in 3.0588 HRD-in -78.44, -57.38 73.64, 19.34 in-in-in SNCiii in-in ActLoopNT-in 3.0402 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.56, 159.19 APE9-dihe-na 80.63, 125.87 APE8-dihe-in -49.88, 140.65 APE8-rot-in 303.1 APE67-dihe-in -56.41, -19.57 -59.45, -45.78 APE12-dist-in 12.8944 APE11-dist-in 11.8889 APE10-dist-in 7.2502 APE9-dist-in 3.3505 None TPO160 TPO160 XRAY 2.494 0.225 0.246 A 302.0 293.0 4 28 28 0 [[4, 286]] 1.0 9et9 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ET9C P24941 1 296 298.0 HEW:60701,HEW:60702 Type1,Allosteric Active DFGin 6.7768 15.3416 BLAminus -145.5, -178.18 52.74, 79.01 -102.36, 32.74 279.23, 71.65 -77.89, -27.55 in-in in 8.5303 Saltbr-in 3.1949 HRD-in -81.68, -55.92 73.5, 13.51 in-in-in SNCiii in-in ActLoopNT-in 2.8332 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.61, 143.17 APE9-dihe-na 75.3, 125.76 APE8-dihe-in -51.4, 141.63 APE8-rot-in 308.72 APE67-dihe-in -57.1, -22.45 -43.98, -53.09 APE12-dist-in 12.7008 APE11-dist-in 9.9902 APE10-dist-in 7.1499 APE9-dist-in 3.2787 None TPO160 TPO160 XRAY 2.494 0.225 0.246 C 302.0 286.0 10 28 28 0 [[4, 286]] 1.0 9et9 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 6Q3FA P24941 1 298 298.0 HEW:60301 Allosteric Inactive None 11.3609 18.4849 None -100.23, 146.03 76.96, 22.05 -56.57, 140.57 248.16, 89.95 83.91, -13.62 out-out out 15.3636 Saltbr-out 17.7399 HRD-in -87.95, -62.63 79.68, -15.73 out-out-out SNCooo out-out ActLoopNT-out 5.7342 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.97, 126.52 APE9-dihe-na -73.61, 124.69 APE8-dihe-in -63.01, 140.77 APE8-rot-out 188.63 APE67-dihe-in -61.19, -27.7 -97.02, -5.86 APE12-dist-out 20.2441 APE11-dist-out 17.6054 APE10-dist-out 18.9112 APE9-dist-out 10.2777 None None OCS177 XRAY 1.18 0.163 0.189 A 306.0 289.0 9 28 28 0 [[4, 286]] 1.0 6q3f Homo sapiens CMGC_CDK2_HUMAN CMGC 7e-90 307.7 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2

Ligand: HEW

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name