Ligand: G4J

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6DBNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK1-2 JAK1_HUMAN 6DBNA P23458 867 1154 1154.0 G4J:4000 Type1 Inactive DFGin 6.3393 13.2699 ABAminus -106.28, 2.12 -151.4, 144.25 -137.1, 32.6 295.8, 96.91 -66.86, -18.69 in-in in 7.5962 Saltbr-in 2.792 HRD-in -66.34, -50.63 70.35, -1.99 in-in-in SNCiii in-in ActLoopNT-in 2.8102 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -142.87, 84.26 APE9-dihe-in -94.42, 151.25 APE8-dihe-in -77.55, 83.04 APE8-rot-na 28.37 APE67-dihe-in -75.2, -10.39 -60.86, -28.98 APE12-dist-na 9.3019 APE11-dist-na 11.0309 APE10-dist-na 10.8091 APE9-dist-in 6.0103 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.48 0.19 0.262 A 316.0 281.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 6dbn TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR TYK2-2 TYK2_HUMAN 6DBMA P29597 889 1178 1187.0 G4J:4000 Type1 Inactive DFGin 6.4024 13.381 ABAminus -104.02, 1.7 -152.49, 145.86 -137.95, 42.02 302.25, 86.41 -67.57, -26.89 in-in in 8.8512 Saltbr-in 2.6986 HRD-in -93.72, -57.81 77.91, 10.17 in-in-out SNCiio in-out ActLoopNT-in 2.8689 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.24, 0.6 APE9-dihe-in -73.63, 132.77 APE8-dihe-in -74.36, 72.39 APE8-rot-na 28.5 APE67-dihe-in -74.28, -1.08 -60.7, -31.84 APE12-dist-na 10.0783 APE11-dist-na 13.1856 APE10-dist-na 9.6852 APE9-dist-in 6.4209 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.368 0.204 0.264 A 318.0 274.0 16 31 28 3 [[589, 868], [897, 1171]] 2.0 6dbm TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: G4J

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 6DBNA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK1-2 JAK1_HUMAN 6DBNA P23458 867 1154 1154.0 G4J:4000 Type1 Inactive DFGin 6.3393 13.2699 ABAminus -106.28, 2.12 -151.4, 144.25 -137.1, 32.6 295.8, 96.91 -66.86, -18.69 in-in in 7.5962 Saltbr-in 2.792 HRD-in -66.34, -50.63 70.35, -1.99 in-in-in SNCiii in-in ActLoopNT-in 2.8102 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -142.87, 84.26 APE9-dihe-in -94.42, 151.25 APE8-dihe-in -77.55, 83.04 APE8-rot-na 28.37 APE67-dihe-in -75.2, -10.39 -60.86, -28.98 APE12-dist-na 9.3019 APE11-dist-na 11.0309 APE10-dist-na 10.8091 APE9-dist-in 6.0103 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.48 0.19 0.262 A 316.0 281.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 6dbn Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR TYK2-2 TYK2_HUMAN 6DBMA P29597 889 1178 1187.0 G4J:4000 Type1 Inactive DFGin 6.4024 13.381 ABAminus -104.02, 1.7 -152.49, 145.86 -137.95, 42.02 302.25, 86.41 -67.57, -26.89 in-in in 8.8512 Saltbr-in 2.6986 HRD-in -93.72, -57.81 77.91, 10.17 in-in-out SNCiio in-out ActLoopNT-in 2.8689 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -82.24, 0.6 APE9-dihe-in -73.63, 132.77 APE8-dihe-in -74.36, 72.39 APE8-rot-na 28.5 APE67-dihe-in -74.28, -1.08 -60.7, -31.84 APE12-dist-na 10.0783 APE11-dist-na 13.1856 APE10-dist-na 9.6852 APE9-dist-in 6.4209 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 2.368 0.204 0.264 A 318.0 274.0 16 31 28 3 [[589, 868], [897, 1171]] 2.0 6dbm Homo sapiens TYR_TYK2-2_HUMAN TYR 5.1e-82 281.0 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: G4J

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name