Ligand: EMU

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4QP1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 4QP1A P28482 12 360 360.0 EMU:401 Type1 Inactive DFGin 6.9626 16.2282 BLAminus -131.47, 175.74 65.18, 79.32 -100.68, 29.14 286.53, 66.72 -63.4, -33.69 out-out out 10.0382 Saltbr-out 3.9837 HRD-in -69.26, -48.17 74.21, -5.61 out-in-out SNCoio in-out ActLoopNT-in 2.698 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -61.27, 168.08 APE9-dihe-na -77.59, 175.7 APE8-dihe-in -63.31, 118.92 APE8-rot-in 314.45 APE67-dihe-in -61.09, -22.53 -42.79, -50.97 APE12-dist-in 9.9501 APE11-dist-out 7.4936 APE10-dist-out 9.8647 APE9-dist-in 4.1107 None None NEP125 XRAY 2.7 0.206 0.255 A 369.0 343.0 0 31 31 0 [[25, 313]] 1.0 4qp1 CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4QP1B P28482 12 357 360.0 EMU:401 Type1 Inactive DFGin 6.6903 15.7386 BLAminus -124.13, -176.14 57.57, 85.87 -105.59, 31.14 285.08, 67.96 -70.32, -24.06 in-out in 9.5661 Saltbr-out 3.9932 HRD-in -75.52, -44.16 67.6, 8.01 out-in-out SNCoio in-out ActLoopNT-in 2.7216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -127.44, 102.2 APE9-dihe-na 68.05, 148.06 APE8-dihe-in -61.45, 136.17 APE8-rot-in 303.04 APE67-dihe-in -60.44, -20.34 -48.19, -50.72 APE12-dist-in 8.9194 APE11-dist-in 8.2741 APE10-dist-out 8.2601 APE9-dist-in 3.1613 None None NEP125 XRAY 2.7 0.206 0.255 B 369.0 344.0 2 31 31 0 [[25, 313]] 1.0 4qp1 CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1

Ligand: EMU

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 4YXSA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_BOVIN 4YXSA P00517 15 351 351.0 EMU:60401 Type1 Active DFGin 6.2857 13.5939 BLAminus -119.26, 168.5 67.4, 97.14 -108.4, 23.82 281.89, 73.4 -58.43, -25.53 in-in in 8.6608 Saltbr-in 2.6403 HRD-in -81.58, -52.24 65.52, 13.45 in-in-in SNCiii in-in ActLoopNT-in 2.9722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.78, 159.45 APE9-dihe-na 131.68, -155.75 APE8-dihe-in -118.67, 131.09 APE8-rot-in 300.67 APE67-dihe-in -60.75, -29.57 -37.55, -53.5 APE12-dist-in 7.9379 APE11-dist-in 11.2743 APE10-dist-in 5.702 APE9-dist-in 3.6169 None TPO198,SEP339 TPO198,SEP339 XRAY 2.11 0.179 0.232 A 350.0 337.0 0 25 25 0 [[44, 298]] 1.0 4yxs Bos taurus AGC_PRKACA_BOVIN AGC 1.4e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC MAPK1 MK01_HUMAN 4QP1A P28482 12 360 360.0 EMU:401 Type1 Inactive DFGin 6.9626 16.2282 BLAminus -131.47, 175.74 65.18, 79.32 -100.68, 29.14 286.53, 66.72 -63.4, -33.69 out-out out 10.0382 Saltbr-out 3.9837 HRD-in -69.26, -48.17 74.21, -5.61 out-in-out SNCoio in-out ActLoopNT-in 2.698 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -61.27, 168.08 APE9-dihe-na -77.59, 175.7 APE8-dihe-in -63.31, 118.92 APE8-rot-in 314.45 APE67-dihe-in -61.09, -22.53 -42.79, -50.97 APE12-dist-in 9.9501 APE11-dist-out 7.4936 APE10-dist-out 9.8647 APE9-dist-in 4.1107 None None NEP125 XRAY 2.7 0.206 0.255 A 369.0 343.0 0 31 31 0 [[25, 313]] 1.0 4qp1 Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4QP1B P28482 12 357 360.0 EMU:401 Type1 Inactive DFGin 6.6903 15.7386 BLAminus -124.13, -176.14 57.57, 85.87 -105.59, 31.14 285.08, 67.96 -70.32, -24.06 in-out in 9.5661 Saltbr-out 3.9932 HRD-in -75.52, -44.16 67.6, 8.01 out-in-out SNCoio in-out ActLoopNT-in 2.7216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -127.44, 102.2 APE9-dihe-na 68.05, 148.06 APE8-dihe-in -61.45, 136.17 APE8-rot-in 303.04 APE67-dihe-in -60.44, -20.34 -48.19, -50.72 APE12-dist-in 8.9194 APE11-dist-in 8.2741 APE10-dist-out 8.2601 APE9-dist-in 3.1613 None None NEP125 XRAY 2.7 0.206 0.255 B 369.0 344.0 2 31 31 0 [[25, 313]] 1.0 4qp1 Homo sapiens CMGC_MAPK1_HUMAN CMGC 1e-85 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1

Ligand: EMU

Total number of chains: 1
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 4YXSA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_BOVIN 4YXSA P00517 15 351 351.0 EMU:60401 Type1 Active DFGin 6.2857 13.5939 BLAminus -119.26, 168.5 67.4, 97.14 -108.4, 23.82 281.89, 73.4 -58.43, -25.53 in-in in 8.6608 Saltbr-in 2.6403 HRD-in -81.58, -52.24 65.52, 13.45 in-in-in SNCiii in-in ActLoopNT-in 2.9722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.78, 159.45 APE9-dihe-na 131.68, -155.75 APE8-dihe-in -118.67, 131.09 APE8-rot-in 300.67 APE67-dihe-in -60.75, -29.57 -37.55, -53.5 APE12-dist-in 7.9379 APE11-dist-in 11.2743 APE10-dist-in 5.702 APE9-dist-in 3.6169 None TPO198,SEP339 TPO198,SEP339 XRAY 2.11 0.179 0.232 A 350.0 337.0 0 25 25 0 [[44, 298]] 1.0 4yxs Bos taurus AGC_PRKACA_BOVIN AGC 1.4e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha