Ligand: CUE

Total number of chains: 3
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6HNWA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CSNK2A1 CSK21_HUMAN 6HNWA P68400 3 330 391.0 CUE:401 Type1 Active DFGin 7.5658 16.0949 BLAminus -123.68, -178.88 50.26, 79.04 -93.91, 23.5 295.35, 80.6 -71.85, -15.46 in-in in 9.116 Saltbr-in 2.7405 HRD-in -75.34, -47.51 67.24, 12.01 in-in-in SNCiii in-in ActLoopNT-in 2.9996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.35, 175.74 APE9-dihe-na 59.54, 171.51 APE8-dihe-in -93.9, 154.31 APE8-rot-in 300.12 APE67-dihe-in -68.85, -15.18 -46.41, -51.19 APE12-dist-in 12.7485 APE11-dist-in 10.5081 APE10-dist-in 6.1628 APE9-dist-in 3.2083 None None None XRAY 2.0 0.19 0.225 A 336.0 328.0 0 27 27 0 [[39, 324]] 1.0 6hnw CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC DYRK1A DYR1A_HUMAN 8YEVA Q13627 135 480 763.0 CUE:501 Type1 Active DFGin 7.4342 14.7861 BLAminus -118.94, 172.54 64.6, 78.63 -91.29, 26.52 288.98, 71.88 -65.34, -22.12 in-in in 8.5216 Saltbr-in 2.577 HRD-in -68.73, -47.85 77.13, 4.82 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.05, 170.5 APE9-dihe-na 69.2, 142.92 APE8-dihe-in -70.94, 147.42 APE8-rot-in 313.88 APE67-dihe-in -60.8, -23.15 -60.0, -43.7 APE12-dist-in 12.5559 APE11-dist-in 11.3833 APE10-dist-in 7.2942 APE9-dist-in 3.1518 None PTR321 PTR321 XRAY 2.252 0.187 0.239 A 360.0 346.0 0 25 25 0 [[159, 479]] 1.0 8yev CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8YEVB Q13627 135 480 763.0 CUE:501 Type1 Active DFGin 7.1597 14.7233 BLAminus -120.23, 173.78 62.44, 74.7 -88.8, 24.95 292.77, 72.65 -67.21, -11.0 in-in in 8.4978 Saltbr-in 2.8726 HRD-in -63.02, -42.24 73.2, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.6626 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.96, 167.57 APE9-dihe-na 75.54, 148.76 APE8-dihe-in -70.82, 139.27 APE8-rot-in 281.75 APE67-dihe-in -60.51, -21.18 -55.07, -44.69 APE12-dist-in 12.7955 APE11-dist-in 11.4333 APE10-dist-in 7.2666 APE9-dist-in 3.1346 None PTR321 PTR321 XRAY 2.252 0.187 0.239 B 360.0 341.0 5 25 25 0 [[159, 479]] 1.0 8yev CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: CUE

Total number of chains: 3
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 6HNWA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CSNK2A1 CSK21_HUMAN 6HNWA P68400 3 330 391.0 CUE:401 Type1 Active DFGin 7.5658 16.0949 BLAminus -123.68, -178.88 50.26, 79.04 -93.91, 23.5 295.35, 80.6 -71.85, -15.46 in-in in 9.116 Saltbr-in 2.7405 HRD-in -75.34, -47.51 67.24, 12.01 in-in-in SNCiii in-in ActLoopNT-in 2.9996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.35, 175.74 APE9-dihe-na 59.54, 171.51 APE8-dihe-in -93.9, 154.31 APE8-rot-in 300.12 APE67-dihe-in -68.85, -15.18 -46.41, -51.19 APE12-dist-in 12.7485 APE11-dist-in 10.5081 APE10-dist-in 6.1628 APE9-dist-in 3.2083 None None None XRAY 2.0 0.19 0.225 A 336.0 328.0 0 27 27 0 [[39, 324]] 1.0 6hnw Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC DYRK1A DYR1A_HUMAN 8YEVA Q13627 135 480 763.0 CUE:501 Type1 Active DFGin 7.4342 14.7861 BLAminus -118.94, 172.54 64.6, 78.63 -91.29, 26.52 288.98, 71.88 -65.34, -22.12 in-in in 8.5216 Saltbr-in 2.577 HRD-in -68.73, -47.85 77.13, 4.82 in-in-in SNCiii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.05, 170.5 APE9-dihe-na 69.2, 142.92 APE8-dihe-in -70.94, 147.42 APE8-rot-in 313.88 APE67-dihe-in -60.8, -23.15 -60.0, -43.7 APE12-dist-in 12.5559 APE11-dist-in 11.3833 APE10-dist-in 7.2942 APE9-dist-in 3.1518 None PTR321 PTR321 XRAY 2.252 0.187 0.239 A 360.0 346.0 0 25 25 0 [[159, 479]] 1.0 8yev Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 8YEVB Q13627 135 480 763.0 CUE:501 Type1 Active DFGin 7.1597 14.7233 BLAminus -120.23, 173.78 62.44, 74.7 -88.8, 24.95 292.77, 72.65 -67.21, -11.0 in-in in 8.4978 Saltbr-in 2.8726 HRD-in -63.02, -42.24 73.2, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.6626 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.96, 167.57 APE9-dihe-na 75.54, 148.76 APE8-dihe-in -70.82, 139.27 APE8-rot-in 281.75 APE67-dihe-in -60.51, -21.18 -55.07, -44.69 APE12-dist-in 12.7955 APE11-dist-in 11.4333 APE10-dist-in 7.2666 APE9-dist-in 3.1346 None PTR321 PTR321 XRAY 2.252 0.187 0.239 B 360.0 341.0 5 25 25 0 [[159, 479]] 1.0 8yev Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Ligand: CUE

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name