Ligand: BI8

Total number of chains: 3
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 2VD5A
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC DMPK DMPK_HUMAN 2VD5A Q09013 11 416 629.0 BI8:1417 Type1 Active DFGin 6.454 13.714 BLAminus -135.51, 173.02 64.16, 82.57 -103.69, 18.13 299.09, 90.62 -77.9, 10.3 in-in in 8.8 Saltbr-in 2.505 HRD-in -77.17, -55.14 72.28, 14.55 in-in-in SNCiii in-in ActLoopNT-in 3.041 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.26, 159.56 APE9-dihe-na 91.29, 143.9 APE8-dihe-in -51.98, 129.25 APE8-rot-in 309.4 APE67-dihe-in -62.16, -18.51 -40.32, -51.73 APE12-dist-in 10.917 APE11-dist-in 10.832 APE10-dist-in 5.147 APE9-dist-in 3.422 None None None XRAY 2.8 0.198 0.244 A 412 390 4 0 0 0 [[71, 339]] 1.0 2vd5 AGC_DMPK_HUMAN AGC 2.1e-89 305.1 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC DMPK DMPK_HUMAN 2VD5B Q09013 11 416 629.0 BI8:1417 Type1 Active DFGin 6.584 14.066 BLAminus -121.55, -178.43 55.14, 76.32 -92.54, 18.35 300.48, 94.03 -63.79, -6.57 in-in in 8.838 Saltbr-in 2.497 HRD-in -79.22, -52.08 70.41, 5.71 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.77, 162.62 APE9-dihe-na 96.06, 164.49 APE8-dihe-in -76.33, 130.66 APE8-rot-in 327.06 APE67-dihe-in -66.1, -27.98 -47.72, -38.95 APE12-dist-in 11.28 APE11-dist-in 11.013 APE10-dist-in 5.474 APE9-dist-in 3.936 None None None XRAY 2.8 0.198 0.244 B 412 380 11 0 0 0 [[71, 339]] 1.0 2vd5 AGC_DMPK_HUMAN AGC 2.1e-89 305.1 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC PDPK1 PDPK1_HUMAN 1UVRA O15530 71 359 556.0 BI8:1372 Type1 Inactive DFGin 6.581 14.406 BLAminus -141.7, -169.27 62.75, 72.58 -105.41, 8.55 300.9, 81.55 -59.95, -35.71 in-in in 8.595 Saltbr-in 2.983 HRD-in -62.43, -49.82 76.81, -6.44 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -133.17, 120.18 APE9-dihe-na -60.87, -168.42 APE8-dihe-in -53.67, 135.35 APE8-rot-in 308.99 APE67-dihe-in -63.6, -1.85 -44.81, -56.98 APE12-dist-in 7.288 APE11-dist-out 6.643 APE10-dist-out 10.614 APE9-dist-in 4.09 None SEP241 SEP241 XRAY 2.81 0.176 0.248 A 289 285 4 0 0 4 [[82, 342]] 1.0 1uvr AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1

Ligand: BI8

Total number of chains: 3
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 2VD5A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC DMPK DMPK_HUMAN 2VD5A Q09013 11 416 629.0 BI8:1417 Type1 Active DFGin 6.454 13.714 BLAminus -135.51, 173.02 64.16, 82.57 -103.69, 18.13 299.09, 90.62 -77.9, 10.3 in-in in 8.8 Saltbr-in 2.505 HRD-in -77.17, -55.14 72.28, 14.55 in-in-in SNCiii in-in ActLoopNT-in 3.041 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.26, 159.56 APE9-dihe-na 91.29, 143.9 APE8-dihe-in -51.98, 129.25 APE8-rot-in 309.4 APE67-dihe-in -62.16, -18.51 -40.32, -51.73 APE12-dist-in 10.917 APE11-dist-in 10.832 APE10-dist-in 5.147 APE9-dist-in 3.422 None None None XRAY 2.8 0.198 0.244 A 412 390 4 0 0 0 [[71, 339]] 1.0 2vd5 Homo sapiens AGC_DMPK_HUMAN AGC 2.1e-89 305.1 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC DMPK DMPK_HUMAN 2VD5B Q09013 11 416 629.0 BI8:1417 Type1 Active DFGin 6.584 14.066 BLAminus -121.55, -178.43 55.14, 76.32 -92.54, 18.35 300.48, 94.03 -63.79, -6.57 in-in in 8.838 Saltbr-in 2.497 HRD-in -79.22, -52.08 70.41, 5.71 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.77, 162.62 APE9-dihe-na 96.06, 164.49 APE8-dihe-in -76.33, 130.66 APE8-rot-in 327.06 APE67-dihe-in -66.1, -27.98 -47.72, -38.95 APE12-dist-in 11.28 APE11-dist-in 11.013 APE10-dist-in 5.474 APE9-dist-in 3.936 None None None XRAY 2.8 0.198 0.244 B 412 380 11 0 0 0 [[71, 339]] 1.0 2vd5 Homo sapiens AGC_DMPK_HUMAN AGC 2.1e-89 305.1 1 260 260 212 213 214 216 218 100 119 123 192 194 193 195 260 241 236 235 234 233 232 231 230 149 Myotonin-protein kinase
AGC PDPK1 PDPK1_HUMAN 1UVRA O15530 71 359 556.0 BI8:1372 Type1 Inactive DFGin 6.581 14.406 BLAminus -141.7, -169.27 62.75, 72.58 -105.41, 8.55 300.9, 81.55 -59.95, -35.71 in-in in 8.595 Saltbr-in 2.983 HRD-in -62.43, -49.82 76.81, -6.44 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -133.17, 120.18 APE9-dihe-na -60.87, -168.42 APE8-dihe-in -53.67, 135.35 APE8-rot-in 308.99 APE67-dihe-in -63.6, -1.85 -44.81, -56.98 APE12-dist-in 7.288 APE11-dist-out 6.643 APE10-dist-out 10.614 APE9-dist-in 4.09 None SEP241 SEP241 XRAY 2.81 0.176 0.248 A 289 285 4 0 0 4 [[82, 342]] 1.0 1uvr Homo sapiens AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1

Ligand: BI8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name