Ligand: B7S

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5WP1A
DFGin None 1 50.0% 9NYTA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 5WP1A P28482 15 357 360.0 B7S:401,BEZ:403 Type1,Allosteric Inactive DFGin 6.848 16.821 BLAminus -131.08, 174.79 68.08, 80.16 -96.05, 24.08 289.54, 79.55 -65.36, -26.41 out-out out 10.283 Saltbr-out 6.666 HRD-in -74.08, -53.37 76.14, 3.14 out-in-out SNCoio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.04, -37.91 APE9-dihe-na -67.19, 159.66 APE8-dihe-in -53.56, 128.07 APE8-rot-in 309.0 APE67-dihe-in -66.9, -15.26 -56.35, -46.18 APE12-dist-out 14.188 APE11-dist-in 10.901 APE10-dist-in 7.045 APE9-dist-in 4.421 None None CME127,CME161,CME166 XRAY 1.4 0.142 0.18 A 357 343 0 0 0 0 [[25, 313]] 1.0 5wp1 CMGC_MAPK1_HUMAN CMGC 8.9e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK14 MK14_HUMAN 9NYTA Q16539 5 353 360.0 A1B7S:402,F50:404 Type1,Allosteric Inactive DFGin 4.26 13.08 None -116.13, 155.51 78.56, -1.77 -37.34, 999.0 47.87, 84.48 999.0, 999.0 in-out in 9.556 Saltbr-out 4.08 HRD-in -71.88, -52.7 83.59, -21.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.66 APE8-dihe-out -70.34, -25.73 APE8-rot-out 87.71 APE67-dihe-in -59.45, -18.84 -59.85, -29.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.539 None None None XRAY 2.16 0.195 0.24 A 384 335 14 0 0 14 [[24, 308]] 1.0 9nyt CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14

Ligand: B7S

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5WP1A
DFGin None 1 50.0% 9NYTA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK1 MK01_HUMAN 5WP1A P28482 15 357 360.0 B7S:401,BEZ:403 Type1,Allosteric Inactive DFGin 6.848 16.821 BLAminus -131.08, 174.79 68.08, 80.16 -96.05, 24.08 289.54, 79.55 -65.36, -26.41 out-out out 10.283 Saltbr-out 6.666 HRD-in -74.08, -53.37 76.14, 3.14 out-in-out SNCoio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -97.04, -37.91 APE9-dihe-na -67.19, 159.66 APE8-dihe-in -53.56, 128.07 APE8-rot-in 309.0 APE67-dihe-in -66.9, -15.26 -56.35, -46.18 APE12-dist-out 14.188 APE11-dist-in 10.901 APE10-dist-in 7.045 APE9-dist-in 4.421 None None CME127,CME161,CME166 XRAY 1.4 0.142 0.18 A 357 343 0 0 0 0 [[25, 313]] 1.0 5wp1 Homo sapiens CMGC_MAPK1_HUMAN CMGC 8.9e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK14 MK14_HUMAN 9NYTA Q16539 5 353 360.0 A1B7S:402,F50:404 Type1,Allosteric Inactive DFGin 4.26 13.08 None -116.13, 155.51 78.56, -1.77 -37.34, 999.0 47.87, 84.48 999.0, 999.0 in-out in 9.556 Saltbr-out 4.08 HRD-in -71.88, -52.7 83.59, -21.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 128.66 APE8-dihe-out -70.34, -25.73 APE8-rot-out 87.71 APE67-dihe-in -59.45, -18.84 -59.85, -29.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.539 None None None XRAY 2.16 0.195 0.24 A 384 335 14 0 0 14 [[24, 308]] 1.0 9nyt Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.3e-85 290.9 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14

Ligand: B7S

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name