Ligand: 9ZS

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 5WALA
DFGin BLAminus 1 50.0% 5WEVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 5WEVA O60674 833 1130 1132.0 9ZS:1201 Type1 Active DFGin 6.3363 14.3388 BLAminus -124.44, -159.19 59.63, 63.05 -90.04, 11.06 293.07, 100.36 -64.94, -15.33 in-in in 8.5125 Saltbr-in 3.0996 HRD-in -69.99, -46.25 71.47, -5.34 in-in-in SNCiii in-in ActLoopNT-in 2.8106 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.7, 140.81 APE9-dihe-in -115.07, 150.19 APE8-dihe-in -75.39, 69.78 APE8-rot-na 28.35 APE67-dihe-in -78.28, -1.86 -59.75, -29.31 APE12-dist-na 13.5331 APE11-dist-na 13.1171 APE10-dist-na 13.0383 APE9-dist-in 7.9293 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.854 0.167 0.194 A 319.0 295.0 3 31 31 0 [[545, 807], [849, 1125]] 2.0 5wev TYR_JAK2-2_HUMAN TYR 3.3e-87 298.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 5WALA P29597 890 1176 1187.0 9ZS:61201 Type1 Inactive DFGin 7.181 13.6984 ABAminus -97.25, -15.9 -129.26, 145.58 -139.57, 26.94 290.86, 91.28 -60.49, -34.49 in-in in 8.1858 Saltbr-in 2.7952 HRD-in -78.43, -50.76 68.0, 1.52 in-in-out SNCiio in-out ActLoopNT-in 2.8064 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.25, 6.21 APE9-dihe-in -66.75, 134.63 APE8-dihe-in -82.22, 67.92 APE8-rot-na 22.08 APE67-dihe-in -76.18, -11.03 -54.12, -29.65 APE12-dist-na 9.8359 APE11-dist-na 12.9188 APE10-dist-na 9.4664 APE9-dist-in 6.6126 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.45 0.185 0.243 A 302.0 285.0 2 31 29 2 [[589, 868], [897, 1171]] 2.0 5wal TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: 9ZS

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 5WALA
DFGin BLAminus 1 50.0% 5WEVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 5WEVA O60674 833 1130 1132.0 9ZS:1201 Type1 Active DFGin 6.3363 14.3388 BLAminus -124.44, -159.19 59.63, 63.05 -90.04, 11.06 293.07, 100.36 -64.94, -15.33 in-in in 8.5125 Saltbr-in 3.0996 HRD-in -69.99, -46.25 71.47, -5.34 in-in-in SNCiii in-in ActLoopNT-in 2.8106 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.7, 140.81 APE9-dihe-in -115.07, 150.19 APE8-dihe-in -75.39, 69.78 APE8-rot-na 28.35 APE67-dihe-in -78.28, -1.86 -59.75, -29.31 APE12-dist-na 13.5331 APE11-dist-na 13.1171 APE10-dist-na 13.0383 APE9-dist-in 7.9293 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.854 0.167 0.194 A 319.0 295.0 3 31 31 0 [[545, 807], [849, 1125]] 2.0 5wev Homo sapiens TYR_JAK2-2_HUMAN TYR 3.3e-87 298.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR TYK2-2 TYK2_HUMAN 5WALA P29597 890 1176 1187.0 9ZS:61201 Type1 Inactive DFGin 7.181 13.6984 ABAminus -97.25, -15.9 -129.26, 145.58 -139.57, 26.94 290.86, 91.28 -60.49, -34.49 in-in in 8.1858 Saltbr-in 2.7952 HRD-in -78.43, -50.76 68.0, 1.52 in-in-out SNCiio in-out ActLoopNT-in 2.8064 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.25, 6.21 APE9-dihe-in -66.75, 134.63 APE8-dihe-in -82.22, 67.92 APE8-rot-na 22.08 APE67-dihe-in -76.18, -11.03 -54.12, -29.65 APE12-dist-na 9.8359 APE11-dist-na 12.9188 APE10-dist-na 9.4664 APE9-dist-in 6.6126 C936A,Q969A,E971A,K972A,D1023N,C1142A None None XRAY 2.45 0.185 0.243 A 302.0 285.0 2 31 29 2 [[589, 868], [897, 1171]] 2.0 5wal Homo sapiens TYR_TYK2-2_HUMAN TYR 3.6e-81 278.3 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: 9ZS

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name