Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | JAK1-2 | JAK1_HUMAN | 6AAHA | P23458 | 865 | 1154 | 1154.0 | 9T6:1201 | Type1 | Inactive | DFGin | 6.319 | 13.457 | ABAminus | -111.86, -1.07 | -147.59, 142.74 | -130.77, 31.7 | 296.21, 81.89 | -59.29, -31.87 | in-in | in | 7.837 | Saltbr-in | 2.785 | HRD-in | -79.04, -51.9 | 74.79, 8.24 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.804 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -100.78, 24.87 | APE9-dihe-in | -65.36, 146.43 | APE8-dihe-in | -84.69, 80.23 | APE8-rot-na | 32.65 | APE67-dihe-in | -73.6, -4.54 | -60.24, -33.63 | APE12-dist-na | 10.501 | APE11-dist-na | 13.066 | APE10-dist-na | 9.901 | APE9-dist-in | 6.422 | None | PTR1034,PTR1035 | PTR1034,PTR1035 | XRAY | 1.83 | 0.225 | 0.255 | A | 290 | 285 | 5 | 0 | 0 | 0 | [[583, 847], [875, 1151]] | 2.0 | 6aah | TYR_JAK1-2_HUMAN | TYR | 1.9e-87 | 298.9 | 2 | 259 | 258 | 1020 | 1021 | 1022 | 1024 | 1026 | 908 | 925 | 929 | 1000 | 1002 | 1001 | 1003 | 1063 | 1051 | 1046 | 1045 | 1044 | 1043 | 1042 | 1041 | 1040 | 957 | Tyrosine-protein kinase JAK1 |
| TYR | JAK1-2 | JAK1_HUMAN | 6AAHB | P23458 | 865 | 1154 | 1154.0 | 9T6:1201 | Type1 | Inactive | DFGin | 6.462 | 13.588 | ABAminus | -114.68, 9.66 | -151.81, 133.96 | -131.35, 23.59 | 291.95, 87.28 | -61.54, -23.21 | in-in | in | 8.041 | Saltbr-in | 2.614 | HRD-in | -74.7, -48.84 | 74.08, 5.49 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.783 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -85.14, 67.65 | APE9-dihe-in | -109.05, 132.69 | APE8-dihe-in | -79.19, 76.3 | APE8-rot-na | 35.14 | APE67-dihe-in | -76.24, -3.1 | -57.7, -33.14 | APE12-dist-na | 10.191 | APE11-dist-na | 12.461 | APE10-dist-na | 9.141 | APE9-dist-in | 6.543 | None | PTR1034,PTR1035 | PTR1034,PTR1035 | XRAY | 1.83 | 0.225 | 0.255 | B | 290 | 286 | 4 | 0 | 0 | 0 | [[583, 847], [875, 1151]] | 2.0 | 6aah | TYR_JAK1-2_HUMAN | TYR | 1.9e-87 | 298.9 | 2 | 259 | 258 | 1020 | 1021 | 1022 | 1024 | 1026 | 908 | 925 | 929 | 1000 | 1002 | 1001 | 1003 | 1063 | 1051 | 1046 | 1045 | 1044 | 1043 | 1042 | 1041 | 1040 | 957 | Tyrosine-protein kinase JAK1 |
| TYR | JAK2-2 | JAK2_HUMAN | 6AAJA | O60674 | 843 | 1130 | 1132.0 | 9T6:1201 | Type1 | Active | DFGin | 6.538 | 14.489 | BLAminus | -115.63, -164.58 | 40.59, 91.02 | -103.17, 27.63 | 288.93, 89.27 | -64.3, -31.13 | in-in | in | 8.29 | Saltbr-in | 3.264 | HRD-in | -73.79, -50.75 | 76.22, -8.05 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.662 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -60.45, 121.7 | APE9-dihe-in | -116.64, 165.17 | APE8-dihe-in | -82.47, 75.26 | APE8-rot-na | 26.67 | APE67-dihe-in | -77.47, -9.05 | -66.38, -30.21 | APE12-dist-na | 11.304 | APE11-dist-na | 10.897 | APE10-dist-na | 12.893 | APE9-dist-in | 7.857 | K943A,K945A | PTR1007,PTR1008 | PTR1007,PTR1008 | XRAY | 2.37 | 0.211 | 0.262 | A | 299 | 283 | 5 | 0 | 0 | 0 | [[545, 807], [849, 1125]] | 2.0 | 6aaj | TYR_JAK2-2_HUMAN | TYR | 1.1e-86 | 296.3 | 1 | 260 | 260 | 993 | 994 | 995 | 997 | 999 | 882 | 898 | 902 | 973 | 975 | 974 | 976 | 1036 | 1024 | 1019 | 1018 | 1017 | 1016 | 1015 | 1014 | 1013 | 930 | Tyrosine-protein kinase JAK2 |
| TYR | JAK2-2 | JAK2_HUMAN | 6AAJB | O60674 | 843 | 1131 | 1132.0 | 9T6:1201 | Type1 | Active | DFGin | 6.545 | 14.395 | BLAminus | -118.96, -159.53 | 45.76, 82.33 | -100.65, 20.72 | 287.12, 93.43 | -66.06, -21.73 | in-in | in | 8.544 | Saltbr-in | 2.844 | HRD-in | -65.44, -45.07 | 71.55, -13.22 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.882 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -115.56, 105.36 | APE9-dihe-in | -102.08, 153.39 | APE8-dihe-in | -76.19, 74.45 | APE8-rot-na | 31.79 | APE67-dihe-in | -76.6, 0.02 | -66.92, -30.87 | APE12-dist-na | 999.0 | APE11-dist-na | 12.177 | APE10-dist-na | 12.802 | APE9-dist-in | 7.814 | K943A,K945A | PTR1007,PTR1008 | PTR1007,PTR1008 | XRAY | 2.37 | 0.211 | 0.262 | B | 299 | 274 | 15 | 0 | 0 | 2 | [[545, 807], [849, 1125]] | 2.0 | 6aaj | TYR_JAK2-2_HUMAN | TYR | 1.1e-86 | 296.3 | 1 | 260 | 260 | 993 | 994 | 995 | 997 | 999 | 882 | 898 | 902 | 973 | 975 | 974 | 976 | 1036 | 1024 | 1019 | 1018 | 1017 | 1016 | 1015 | 1014 | 1013 | 930 | Tyrosine-protein kinase JAK2 |
| TYR | JAK3-2 | JAK3_HUMAN | 6AAKA | P52333 | 815 | 1098 | 1124.0 | 9T6:1201 | Type1 | Inactive | DFGin | 6.426 | 14.488 | BLAminus | -141.28, -175.48 | 60.31, 80.99 | -97.75, 30.98 | 284.74, 77.33 | -61.02, -46.05 | in-in | in | 8.525 | Saltbr-in | 2.67 | HRD-in | -75.62, -45.99 | 77.6, -18.1 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.736 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -74.2, -11.07 | APE9-dihe-in | -68.95, 155.07 | APE8-dihe-in | -47.57, 131.1 | APE8-rot-na | 329.72 | APE67-dihe-in | -73.4, -26.9 | -66.76, -22.48 | APE12-dist-na | 11.993 | APE11-dist-na | 8.673 | APE10-dist-na | 11.398 | APE9-dist-in | 7.47 | C1040S,C1048S | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.67 | 0.269 | 0.326 | A | 287 | 277 | 7 | 0 | 0 | 0 | [[521, 779], [822, 1097]] | 2.0 | 6aak | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1 | 260 | 260 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6AAKB | P52333 | 815 | 1100 | 1124.0 | 9T6:1201 | Type1 | Inactive | DFGin | 6.549 | 14.313 | BLAminus | -132.57, -171.05 | 56.03, 83.09 | -98.42, 24.6 | 281.38, 75.24 | -63.47, -40.11 | in-in | in | 8.036 | Saltbr-in | 2.755 | HRD-in | -65.5, -48.18 | 78.33, -13.38 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.907 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -123.61, -28.55 | APE9-dihe-in | -64.46, 151.35 | APE8-dihe-in | -40.19, 130.42 | APE8-rot-na | 326.93 | APE67-dihe-in | -77.17, -14.56 | -72.74, -10.57 | APE12-dist-na | 13.108 | APE11-dist-na | 9.526 | APE10-dist-na | 10.085 | APE9-dist-in | 7.203 | C1040S,C1048S | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.67 | 0.269 | 0.326 | B | 287 | 285 | 1 | 0 | 0 | 0 | [[521, 779], [822, 1097]] | 2.0 | 6aak | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1 | 260 | 260 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6AAKC | P52333 | 814 | 1099 | 1124.0 | 9T6:1201 | Type1 | Active | DFGin | 6.788 | 14.635 | BLAminus | -114.47, 172.4 | 69.03, 86.81 | -107.19, 29.58 | 286.76, 78.99 | -58.47, -55.72 | in-in | in | 8.241 | Saltbr-in | 2.724 | HRD-in | -89.94, -41.82 | 71.73, -3.81 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.783 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -68.85, 76.94 | APE9-dihe-in | -171.36, 163.86 | APE8-dihe-in | -58.47, 128.31 | APE8-rot-na | 338.62 | APE67-dihe-in | -73.56, -5.95 | -79.88, -15.99 | APE12-dist-na | 12.975 | APE11-dist-na | 9.218 | APE10-dist-na | 10.399 | APE9-dist-in | 7.751 | C1040S,C1048S | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.67 | 0.269 | 0.326 | C | 287 | 276 | 10 | 0 | 0 | 0 | [[521, 779], [822, 1097]] | 2.0 | 6aak | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1 | 260 | 260 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6AAKD | P52333 | 814 | 1098 | 1124.0 | 9T6:1201 | Type1 | None | DFGin | 6.331 | 14.138 | BLAminus | -145.03, 168.99 | 56.55, 97.11 | -103.75, 32.24 | 293.47, 81.71 | -62.01, -33.71 | in-in | in | 8.018 | Saltbr-in | 2.856 | HRD-in | -76.49, -42.81 | 76.74, -36.27 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.766 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 72.65 | APE8-dihe-in | -50.29, 134.06 | APE8-rot-na | 332.19 | APE67-dihe-in | -63.85, -16.03 | -70.13, -20.9 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.384 | C1040S,C1048S | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.67 | 0.269 | 0.326 | D | 287 | 268 | 17 | 0 | 0 | 5 | [[521, 779], [822, 1097]] | 2.0 | 6aak | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1 | 260 | 260 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | TYK2-2 | TYK2_HUMAN | 6AAMA | P29597 | 888 | 1178 | 1187.0 | 9T6:1201 | Type1 | None | DFGin | 6.808 | 13.614 | BLAminus | -114.96, -166.83 | 46.97, 77.56 | -91.7, 20.81 | 290.41, 78.57 | -55.84, -27.39 | in-in | in | 7.95 | Saltbr-in | 2.732 | HRD-in | -93.28, -50.85 | 70.68, 8.06 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.803 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, 25.87 | APE8-rot-na | 15.0 | APE67-dihe-in | -73.41, -4.27 | -60.18, -33.47 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | C936A,Q969A,E971A,K972A,D1023N,I1114L,C1142A | None | None | XRAY | 1.98 | 0.204 | 0.238 | A | 298 | 269 | 22 | 0 | 0 | 14 | [[589, 868], [897, 1171]] | 2.0 | 6aam | TYR_TYK2-2_HUMAN | TYR | 3.4e-81 | 278.3 | 2 | 260 | 259 | 1040 | 1041 | 1042 | 1044 | 1046 | 930 | 947 | 951 | 1020 | 1022 | 1021 | 1023 | 1083 | 1071 | 1066 | 1065 | 1064 | 1063 | 1062 | 1061 | 1060 | 979 | Non-receptor tyrosine-protein kinase TYK2 |
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TYR | JAK1-2 | JAK1_HUMAN | 6AAHA | P23458 | 865 | 1154 | 1154.0 | 9T6:1201 | Type1 | Inactive | DFGin | 6.319 | 13.457 | ABAminus | -111.86, -1.07 | -147.59, 142.74 | -130.77, 31.7 | 296.21, 81.89 | -59.29, -31.87 | in-in | in | 7.837 | Saltbr-in | 2.785 | HRD-in | -79.04, -51.9 | 74.79, 8.24 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.804 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -100.78, 24.87 | APE9-dihe-in | -65.36, 146.43 | APE8-dihe-in | -84.69, 80.23 | APE8-rot-na | 32.65 | APE67-dihe-in | -73.6, -4.54 | -60.24, -33.63 | APE12-dist-na | 10.501 | APE11-dist-na | 13.066 | APE10-dist-na | 9.901 | APE9-dist-in | 6.422 | None | PTR1034,PTR1035 | PTR1034,PTR1035 | XRAY | 1.83 | 0.225 | 0.255 | A | 290 | 285 | 5 | 0 | 0 | 0 | [[583, 847], [875, 1151]] | 2.0 | 6aah | Homo sapiens | TYR_JAK1-2_HUMAN | TYR | 1.9e-87 | 298.9 | 2 | 259 | 258 | 1020 | 1021 | 1022 | 1024 | 1026 | 908 | 925 | 929 | 1000 | 1002 | 1001 | 1003 | 1063 | 1051 | 1046 | 1045 | 1044 | 1043 | 1042 | 1041 | 1040 | 957 | Tyrosine-protein kinase JAK1 |
| TYR | JAK1-2 | JAK1_HUMAN | 6AAHB | P23458 | 865 | 1154 | 1154.0 | 9T6:1201 | Type1 | Inactive | DFGin | 6.462 | 13.588 | ABAminus | -114.68, 9.66 | -151.81, 133.96 | -131.35, 23.59 | 291.95, 87.28 | -61.54, -23.21 | in-in | in | 8.041 | Saltbr-in | 2.614 | HRD-in | -74.7, -48.84 | 74.08, 5.49 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.783 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -85.14, 67.65 | APE9-dihe-in | -109.05, 132.69 | APE8-dihe-in | -79.19, 76.3 | APE8-rot-na | 35.14 | APE67-dihe-in | -76.24, -3.1 | -57.7, -33.14 | APE12-dist-na | 10.191 | APE11-dist-na | 12.461 | APE10-dist-na | 9.141 | APE9-dist-in | 6.543 | None | PTR1034,PTR1035 | PTR1034,PTR1035 | XRAY | 1.83 | 0.225 | 0.255 | B | 290 | 286 | 4 | 0 | 0 | 0 | [[583, 847], [875, 1151]] | 2.0 | 6aah | Homo sapiens | TYR_JAK1-2_HUMAN | TYR | 1.9e-87 | 298.9 | 2 | 259 | 258 | 1020 | 1021 | 1022 | 1024 | 1026 | 908 | 925 | 929 | 1000 | 1002 | 1001 | 1003 | 1063 | 1051 | 1046 | 1045 | 1044 | 1043 | 1042 | 1041 | 1040 | 957 | Tyrosine-protein kinase JAK1 |
| TYR | JAK2-2 | JAK2_HUMAN | 6AAJA | O60674 | 843 | 1130 | 1132.0 | 9T6:1201 | Type1 | Active | DFGin | 6.538 | 14.489 | BLAminus | -115.63, -164.58 | 40.59, 91.02 | -103.17, 27.63 | 288.93, 89.27 | -64.3, -31.13 | in-in | in | 8.29 | Saltbr-in | 3.264 | HRD-in | -73.79, -50.75 | 76.22, -8.05 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.662 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -60.45, 121.7 | APE9-dihe-in | -116.64, 165.17 | APE8-dihe-in | -82.47, 75.26 | APE8-rot-na | 26.67 | APE67-dihe-in | -77.47, -9.05 | -66.38, -30.21 | APE12-dist-na | 11.304 | APE11-dist-na | 10.897 | APE10-dist-na | 12.893 | APE9-dist-in | 7.857 | K943A,K945A | PTR1007,PTR1008 | PTR1007,PTR1008 | XRAY | 2.37 | 0.211 | 0.262 | A | 299 | 283 | 5 | 0 | 0 | 0 | [[545, 807], [849, 1125]] | 2.0 | 6aaj | Homo sapiens | TYR_JAK2-2_HUMAN | TYR | 1.1e-86 | 296.3 | 1 | 260 | 260 | 993 | 994 | 995 | 997 | 999 | 882 | 898 | 902 | 973 | 975 | 974 | 976 | 1036 | 1024 | 1019 | 1018 | 1017 | 1016 | 1015 | 1014 | 1013 | 930 | Tyrosine-protein kinase JAK2 |
| TYR | JAK2-2 | JAK2_HUMAN | 6AAJB | O60674 | 843 | 1131 | 1132.0 | 9T6:1201 | Type1 | Active | DFGin | 6.545 | 14.395 | BLAminus | -118.96, -159.53 | 45.76, 82.33 | -100.65, 20.72 | 287.12, 93.43 | -66.06, -21.73 | in-in | in | 8.544 | Saltbr-in | 2.844 | HRD-in | -65.44, -45.07 | 71.55, -13.22 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.882 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -115.56, 105.36 | APE9-dihe-in | -102.08, 153.39 | APE8-dihe-in | -76.19, 74.45 | APE8-rot-na | 31.79 | APE67-dihe-in | -76.6, 0.02 | -66.92, -30.87 | APE12-dist-na | 999.0 | APE11-dist-na | 12.177 | APE10-dist-na | 12.802 | APE9-dist-in | 7.814 | K943A,K945A | PTR1007,PTR1008 | PTR1007,PTR1008 | XRAY | 2.37 | 0.211 | 0.262 | B | 299 | 274 | 15 | 0 | 0 | 2 | [[545, 807], [849, 1125]] | 2.0 | 6aaj | Homo sapiens | TYR_JAK2-2_HUMAN | TYR | 1.1e-86 | 296.3 | 1 | 260 | 260 | 993 | 994 | 995 | 997 | 999 | 882 | 898 | 902 | 973 | 975 | 974 | 976 | 1036 | 1024 | 1019 | 1018 | 1017 | 1016 | 1015 | 1014 | 1013 | 930 | Tyrosine-protein kinase JAK2 |
| TYR | JAK3-2 | JAK3_HUMAN | 6AAKA | P52333 | 815 | 1098 | 1124.0 | 9T6:1201 | Type1 | Inactive | DFGin | 6.426 | 14.488 | BLAminus | -141.28, -175.48 | 60.31, 80.99 | -97.75, 30.98 | 284.74, 77.33 | -61.02, -46.05 | in-in | in | 8.525 | Saltbr-in | 2.67 | HRD-in | -75.62, -45.99 | 77.6, -18.1 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.736 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -74.2, -11.07 | APE9-dihe-in | -68.95, 155.07 | APE8-dihe-in | -47.57, 131.1 | APE8-rot-na | 329.72 | APE67-dihe-in | -73.4, -26.9 | -66.76, -22.48 | APE12-dist-na | 11.993 | APE11-dist-na | 8.673 | APE10-dist-na | 11.398 | APE9-dist-in | 7.47 | C1040S,C1048S | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.67 | 0.269 | 0.326 | A | 287 | 277 | 7 | 0 | 0 | 0 | [[521, 779], [822, 1097]] | 2.0 | 6aak | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1 | 260 | 260 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6AAKB | P52333 | 815 | 1100 | 1124.0 | 9T6:1201 | Type1 | Inactive | DFGin | 6.549 | 14.313 | BLAminus | -132.57, -171.05 | 56.03, 83.09 | -98.42, 24.6 | 281.38, 75.24 | -63.47, -40.11 | in-in | in | 8.036 | Saltbr-in | 2.755 | HRD-in | -65.5, -48.18 | 78.33, -13.38 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.907 | ActLoopCT-out | TYR | APEdihe_oiiai | APEdist_aaai | APE10-dihe-out | -123.61, -28.55 | APE9-dihe-in | -64.46, 151.35 | APE8-dihe-in | -40.19, 130.42 | APE8-rot-na | 326.93 | APE67-dihe-in | -77.17, -14.56 | -72.74, -10.57 | APE12-dist-na | 13.108 | APE11-dist-na | 9.526 | APE10-dist-na | 10.085 | APE9-dist-in | 7.203 | C1040S,C1048S | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.67 | 0.269 | 0.326 | B | 287 | 285 | 1 | 0 | 0 | 0 | [[521, 779], [822, 1097]] | 2.0 | 6aak | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1 | 260 | 260 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6AAKC | P52333 | 814 | 1099 | 1124.0 | 9T6:1201 | Type1 | Active | DFGin | 6.788 | 14.635 | BLAminus | -114.47, 172.4 | 69.03, 86.81 | -107.19, 29.58 | 286.76, 78.99 | -58.47, -55.72 | in-in | in | 8.241 | Saltbr-in | 2.724 | HRD-in | -89.94, -41.82 | 71.73, -3.81 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.783 | ActLoopCT-in | TYR | APEdihe_iiiai | APEdist_aaai | APE10-dihe-in | -68.85, 76.94 | APE9-dihe-in | -171.36, 163.86 | APE8-dihe-in | -58.47, 128.31 | APE8-rot-na | 338.62 | APE67-dihe-in | -73.56, -5.95 | -79.88, -15.99 | APE12-dist-na | 12.975 | APE11-dist-na | 9.218 | APE10-dist-na | 10.399 | APE9-dist-in | 7.751 | C1040S,C1048S | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.67 | 0.269 | 0.326 | C | 287 | 276 | 10 | 0 | 0 | 0 | [[521, 779], [822, 1097]] | 2.0 | 6aak | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1 | 260 | 260 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | JAK3-2 | JAK3_HUMAN | 6AAKD | P52333 | 814 | 1098 | 1124.0 | 9T6:1201 | Type1 | None | DFGin | 6.331 | 14.138 | BLAminus | -145.03, 168.99 | 56.55, 97.11 | -103.75, 32.24 | 293.47, 81.71 | -62.01, -33.71 | in-in | in | 8.018 | Saltbr-in | 2.856 | HRD-in | -76.49, -42.81 | 76.74, -36.27 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.766 | ActLoopCT-none | TYR | APEdihe_nniai | APEdist_aaai | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 72.65 | APE8-dihe-in | -50.29, 134.06 | APE8-rot-na | 332.19 | APE67-dihe-in | -63.85, -16.03 | -70.13, -20.9 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-in | 7.384 | C1040S,C1048S | PTR980,PTR981 | PTR980,PTR981 | XRAY | 2.67 | 0.269 | 0.326 | D | 287 | 268 | 17 | 0 | 0 | 5 | [[521, 779], [822, 1097]] | 2.0 | 6aak | Homo sapiens | TYR_JAK3-2_HUMAN | TYR | 1.9e-81 | 279.1 | 1 | 260 | 260 | 966 | 967 | 968 | 970 | 972 | 855 | 871 | 875 | 946 | 948 | 947 | 949 | 1009 | 997 | 992 | 991 | 990 | 989 | 988 | 987 | 986 | 903 | Tyrosine-protein kinase JAK3 |
| TYR | TYK2-2 | TYK2_HUMAN | 6AAMA | P29597 | 888 | 1178 | 1187.0 | 9T6:1201 | Type1 | None | DFGin | 6.808 | 13.614 | BLAminus | -114.96, -166.83 | 46.97, 77.56 | -91.7, 20.81 | 290.41, 78.57 | -55.84, -27.39 | in-in | in | 7.95 | Saltbr-in | 2.732 | HRD-in | -93.28, -50.85 | 70.68, 8.06 | in-in-none | SNCiin | in-none | ActLoopNT-in | 2.803 | ActLoopCT-none | TYR | APEdihe_nnnai | APEdist_aaan | APE10-dihe-none | 999.0, 999.0 | APE9-dihe-none | 999.0, 999.0 | APE8-dihe-none | 999.0, 25.87 | APE8-rot-na | 15.0 | APE67-dihe-in | -73.41, -4.27 | -60.18, -33.47 | APE12-dist-na | 999.0 | APE11-dist-na | 999.0 | APE10-dist-na | 999.0 | APE9-dist-none | 999.0 | C936A,Q969A,E971A,K972A,D1023N,I1114L,C1142A | None | None | XRAY | 1.98 | 0.204 | 0.238 | A | 298 | 269 | 22 | 0 | 0 | 14 | [[589, 868], [897, 1171]] | 2.0 | 6aam | Homo sapiens | TYR_TYK2-2_HUMAN | TYR | 3.4e-81 | 278.3 | 2 | 260 | 259 | 1040 | 1041 | 1042 | 1044 | 1046 | 930 | 947 | 951 | 1020 | 1022 | 1021 | 1023 | 1083 | 1071 | 1066 | 1065 | 1064 | 1063 | 1062 | 1061 | 1060 | 979 | Non-receptor tyrosine-protein kinase TYK2 |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
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