Ligand: 88A

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 4AQCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 4AQCA O60674 842 1132 1132.0 88A:2001 Type1 Inactive DFGin 6.1498 13.4549 ABAminus -119.36, 0.46 -148.42, 139.35 -130.52, 29.8 295.81, 93.68 -57.31, -31.29 in-in in 8.5884 Saltbr-in 2.6399 HRD-in -68.43, -50.02 76.23, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.7599 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.9, 129.7 APE9-dihe-in -107.31, 146.17 APE8-dihe-in -74.14, 67.42 APE8-rot-na 34.69 APE67-dihe-in -82.32, -4.12 -58.66, -24.6 APE12-dist-na 12.7443 APE11-dist-na 12.8375 APE10-dist-na 12.9622 APE9-dist-in 7.8157 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.178 0.217 A 301.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4aqc TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4AQCB O60674 836 1132 1132.0 88A:2001 Type1 Inactive DFGin 6.3879 13.6889 ABAminus -123.9, -2.65 -148.48, 139.47 -132.14, 28.65 294.89, 80.58 -66.71, -20.79 in-in in 8.4572 Saltbr-in 2.6381 HRD-in -71.57, -47.61 74.96, -4.96 in-in-in SNCiii in-in ActLoopNT-in 2.7435 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.78, 150.42 APE9-dihe-in -118.99, 125.24 APE8-dihe-in -80.6, 74.92 APE8-rot-na 32.88 APE67-dihe-in -80.42, -6.59 -61.14, -25.41 APE12-dist-na 7.9785 APE11-dist-na 9.4667 APE10-dist-na 10.9073 APE9-dist-in 7.6259 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.178 0.217 B 301.0 297.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4aqc TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: 88A

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 4AQCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 4AQCA O60674 842 1132 1132.0 88A:2001 Type1 Inactive DFGin 6.1498 13.4549 ABAminus -119.36, 0.46 -148.42, 139.35 -130.52, 29.8 295.81, 93.68 -57.31, -31.29 in-in in 8.5884 Saltbr-in 2.6399 HRD-in -68.43, -50.02 76.23, -1.23 in-in-in SNCiii in-in ActLoopNT-in 2.7599 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.9, 129.7 APE9-dihe-in -107.31, 146.17 APE8-dihe-in -74.14, 67.42 APE8-rot-na 34.69 APE67-dihe-in -82.32, -4.12 -58.66, -24.6 APE12-dist-na 12.7443 APE11-dist-na 12.8375 APE10-dist-na 12.9622 APE9-dist-in 7.8157 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.178 0.217 A 301.0 291.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4aqc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 4AQCB O60674 836 1132 1132.0 88A:2001 Type1 Inactive DFGin 6.3879 13.6889 ABAminus -123.9, -2.65 -148.48, 139.47 -132.14, 28.65 294.89, 80.58 -66.71, -20.79 in-in in 8.4572 Saltbr-in 2.6381 HRD-in -71.57, -47.61 74.96, -4.96 in-in-in SNCiii in-in ActLoopNT-in 2.7435 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.78, 150.42 APE9-dihe-in -118.99, 125.24 APE8-dihe-in -80.6, 74.92 APE8-rot-na 32.88 APE67-dihe-in -80.42, -6.59 -61.14, -25.41 APE12-dist-na 7.9785 APE11-dist-na 9.4667 APE10-dist-na 10.9073 APE9-dist-in 7.6259 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.9 0.178 0.217 B 301.0 297.0 0 31 31 0 [[545, 807], [849, 1125]] 2.0 4aqc Homo sapiens TYR_JAK2-2_HUMAN TYR 2.7e-87 298.4 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: 88A

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name