Ligand: 85X

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5XGNA
DFGin BLAplus 1 50.0% 5XGMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 5XGNA P00533 697 1020 1210.0 85X:1101 Type1 Inactive DFGin 5.5816 13.6442 BLAminus -153.26, 170.97 58.79, 71.97 -87.87, 19.38 306.48, 67.69 -60.62, -38.74 in-in in 8.8473 Saltbr-in 2.822 HRD-in -68.76, -41.85 71.08, 4.38 in-in-out SNCiio in-out ActLoopNT-in 3.0971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -65.98, -39.97 APE9-dihe-in -71.67, 158.09 APE8-dihe-in -63.95, 139.95 APE8-rot-na 31.68 APE67-dihe-in -61.46, -41.98 -63.96, -39.37 APE12-dist-na 11.9898 APE11-dist-na 9.8526 APE10-dist-na 6.7363 APE9-dist-in 5.7737 T790M,C797S None None XRAY 3.0 0.222 0.251 A 331.0 302.0 0 30 30 0 [[712, 970]] 1.0 5xgn TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5XGMA P00533 696 1019 1210.0 85X:1101 Type1 Inactive DFGin 4.7927 14.7413 BLAplus -144.29, 167.69 73.25, 26.11 -72.78, -33.2 21.91, 88.3 -70.25, 109.4 in-in in 8.876 Saltbr-in 2.9877 HRD-in -64.53, -47.15 68.98, -5.48 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 146.56 APE9-dihe-in -67.52, 143.4 APE8-dihe-in -85.81, 75.7 APE8-rot-na 32.24 APE67-dihe-in -60.03, -28.56 -62.99, -40.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.6171 APE9-dist-out 8.5016 T790M None None XRAY 2.952 0.204 0.232 A 331.0 288.0 20 30 14 16 [[712, 970]] 1.0 5xgm TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 85X

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 5XGNA
DFGin BLAplus 1 50.0% 5XGMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 5XGNA P00533 697 1020 1210.0 85X:1101 Type1 Inactive DFGin 5.5816 13.6442 BLAminus -153.26, 170.97 58.79, 71.97 -87.87, 19.38 306.48, 67.69 -60.62, -38.74 in-in in 8.8473 Saltbr-in 2.822 HRD-in -68.76, -41.85 71.08, 4.38 in-in-out SNCiio in-out ActLoopNT-in 3.0971 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -65.98, -39.97 APE9-dihe-in -71.67, 158.09 APE8-dihe-in -63.95, 139.95 APE8-rot-na 31.68 APE67-dihe-in -61.46, -41.98 -63.96, -39.37 APE12-dist-na 11.9898 APE11-dist-na 9.8526 APE10-dist-na 6.7363 APE9-dist-in 5.7737 T790M,C797S None None XRAY 3.0 0.222 0.251 A 331.0 302.0 0 30 30 0 [[712, 970]] 1.0 5xgn Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5XGMA P00533 696 1019 1210.0 85X:1101 Type1 Inactive DFGin 4.7927 14.7413 BLAplus -144.29, 167.69 73.25, 26.11 -72.78, -33.2 21.91, 88.3 -70.25, 109.4 in-in in 8.876 Saltbr-in 2.9877 HRD-in -64.53, -47.15 68.98, -5.48 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 146.56 APE9-dihe-in -67.52, 143.4 APE8-dihe-in -85.81, 75.7 APE8-rot-na 32.24 APE67-dihe-in -60.03, -28.56 -62.99, -40.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.6171 APE9-dist-out 8.5016 T790M None None XRAY 2.952 0.204 0.232 A 331.0 288.0 20 30 14 16 [[712, 970]] 1.0 5xgm Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 85X

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name