Ligand: 7GT

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 5TQ7A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 5TQ7A O60674 841 1132 1132.0 7GT:4000 Type1 Inactive DFGin 6.3232 13.4468 ABAminus -112.11, 6.39 -155.17, 139.89 -132.33, 31.13 301.67, 84.4 -54.42, -34.31 in-in in 8.2272 Saltbr-in 2.5959 HRD-in -76.61, -45.66 78.1, -8.67 in-in-none SNCiin in-none ActLoopNT-in 2.8613 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.6 APE9-dihe-in -120.25, 145.22 APE8-dihe-in -82.11, 80.94 APE8-rot-na 32.95 APE67-dihe-in -75.04, -9.7 -64.29, -26.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.4218 APE9-dist-in 7.6808 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.229 0.286 A 304.0 277.0 15 31 27 4 [[545, 807], [849, 1125]] 2.0 5tq7 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5TQ7B O60674 843 1132 1132.0 7GT:4000 Type1 Inactive DFGin 6.1068 13.5025 ABAminus -110.47, 5.32 -145.71, 141.14 -137.73, 43.09 299.27, 79.83 -87.98, -15.69 in-in in 8.5743 Saltbr-in 2.5589 HRD-in -74.7, -41.33 71.59, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.8594 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.68, 157.9 APE9-dihe-in -122.63, 153.25 APE8-dihe-in -77.9, 72.47 APE8-rot-na 30.75 APE67-dihe-in -86.98, 6.22 -56.6, -25.3 APE12-dist-na 999.0 APE11-dist-na 11.751 APE10-dist-na 12.4517 APE9-dist-in 7.7775 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.229 0.286 B 304.0 271.0 19 31 28 3 [[545, 807], [849, 1125]] 2.0 5tq7 TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: 7GT

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 5TQ7A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_HUMAN 5TQ7A O60674 841 1132 1132.0 7GT:4000 Type1 Inactive DFGin 6.3232 13.4468 ABAminus -112.11, 6.39 -155.17, 139.89 -132.33, 31.13 301.67, 84.4 -54.42, -34.31 in-in in 8.2272 Saltbr-in 2.5959 HRD-in -76.61, -45.66 78.1, -8.67 in-in-none SNCiin in-none ActLoopNT-in 2.8613 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 130.6 APE9-dihe-in -120.25, 145.22 APE8-dihe-in -82.11, 80.94 APE8-rot-na 32.95 APE67-dihe-in -75.04, -9.7 -64.29, -26.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.4218 APE9-dist-in 7.6808 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.229 0.286 A 304.0 277.0 15 31 27 4 [[545, 807], [849, 1125]] 2.0 5tq7 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5TQ7B O60674 843 1132 1132.0 7GT:4000 Type1 Inactive DFGin 6.1068 13.5025 ABAminus -110.47, 5.32 -145.71, 141.14 -137.73, 43.09 299.27, 79.83 -87.98, -15.69 in-in in 8.5743 Saltbr-in 2.5589 HRD-in -74.7, -41.33 71.59, -12.66 in-in-in SNCiii in-in ActLoopNT-in 2.8594 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.68, 157.9 APE9-dihe-in -122.63, 153.25 APE8-dihe-in -77.9, 72.47 APE8-rot-na 30.75 APE67-dihe-in -86.98, 6.22 -56.6, -25.3 APE12-dist-na 999.0 APE11-dist-na 11.751 APE10-dist-na 12.4517 APE9-dist-in 7.7775 M1073S,F1076T,I1126V PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.1 0.229 0.286 B 304.0 271.0 19 31 28 3 [[545, 807], [849, 1125]] 2.0 5tq7 Homo sapiens TYR_JAK2-2_HUMAN TYR 6.6e-87 297.1 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2

Ligand: 7GT

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name