Ligand: 7G9

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 100.0% 5P9LA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BTK BTK_HUMAN 5P9LA Q06187 392 657 659.0 7G9:701 Type1 Inactive DFGin 6.0865 13.7982 BLBplus -122.11, 164.8 58.63, 30.82 -60.7, 123.17 37.36, 89.52 81.48, -10.88 out-none out 14.5981 Saltbr-none 999.0 HRD-in -66.82, -52.81 82.97, -17.59 none-out-out SNCnoo out-out ActLoopNT-out 8.2767 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 121.97 APE9-dihe-in -75.24, 140.2 APE8-dihe-in -82.91, 65.05 APE8-rot-na 32.95 APE67-dihe-in -69.39, -8.36 -46.7, -47.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.3777 APE9-dist-out 8.43 None None None XRAY 1.25 0.266 0.28 A 279.0 252.0 14 29 19 10 [[402, 653]] 1.0 5p9l TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR EGFR EGFR_HUMAN 7A2AA P00533 700 984 1210.0 57N:1101,7G9:1102 Type3,Type1 Inactive DFGin 4.7896 14.9811 BLBplus -131.59, 170.62 61.54, 34.7 -80.75, 149.06 48.24, 92.48 77.59, 7.85 out-out out 13.5214 Saltbr-out 11.363 HRD-in -68.93, -60.4 81.46, -8.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.16 APE8-dihe-in -83.82, 69.63 APE8-rot-na 32.14 APE67-dihe-in -69.62, -9.49 -57.3, -43.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0196 T790M,V948R None None XRAY 1.9 0.195 0.217 A 333.0 266.0 19 30 13 17 [[712, 970]] 1.0 7a2a TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A2AB P00533 699 984 1210.0 57N:1101,7G9:1102 Type3,Type1 Inactive DFGin 5.4288 14.7542 BLBplus -131.31, 171.38 59.7, 35.33 -84.58, 153.3 50.04, 92.4 77.68, 999.0 out-out out 13.1596 Saltbr-out 10.4376 HRD-in -66.1, -59.16 82.47, -6.26 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.47 APE8-dihe-in -82.95, 68.33 APE8-rot-na 32.13 APE67-dihe-in -69.29, -8.38 -57.66, -41.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1601 T790M,V948R None None XRAY 1.9 0.195 0.217 B 333.0 268.0 18 30 12 18 [[712, 970]] 1.0 7a2a TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 7G9

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 100.0% 5P9LA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BTK BTK_HUMAN 5P9LA Q06187 392 657 659.0 7G9:701 Type1 Inactive DFGin 6.0865 13.7982 BLBplus -122.11, 164.8 58.63, 30.82 -60.7, 123.17 37.36, 89.52 81.48, -10.88 out-none out 14.5981 Saltbr-none 999.0 HRD-in -66.82, -52.81 82.97, -17.59 none-out-out SNCnoo out-out ActLoopNT-out 8.2767 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 121.97 APE9-dihe-in -75.24, 140.2 APE8-dihe-in -82.91, 65.05 APE8-rot-na 32.95 APE67-dihe-in -69.39, -8.36 -46.7, -47.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.3777 APE9-dist-out 8.43 None None None XRAY 1.25 0.266 0.28 A 279.0 252.0 14 29 19 10 [[402, 653]] 1.0 5p9l Homo sapiens TYR_BTK_HUMAN TYR 6.7e-93 316.7 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR EGFR EGFR_HUMAN 7A2AA P00533 700 984 1210.0 57N:1101,7G9:1102 Type3,Type1 Inactive DFGin 4.7896 14.9811 BLBplus -131.59, 170.62 61.54, 34.7 -80.75, 149.06 48.24, 92.48 77.59, 7.85 out-out out 13.5214 Saltbr-out 11.363 HRD-in -68.93, -60.4 81.46, -8.87 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.16 APE8-dihe-in -83.82, 69.63 APE8-rot-na 32.14 APE67-dihe-in -69.62, -9.49 -57.3, -43.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0196 T790M,V948R None None XRAY 1.9 0.195 0.217 A 333.0 266.0 19 30 13 17 [[712, 970]] 1.0 7a2a Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A2AB P00533 699 984 1210.0 57N:1101,7G9:1102 Type3,Type1 Inactive DFGin 5.4288 14.7542 BLBplus -131.31, 171.38 59.7, 35.33 -84.58, 153.3 50.04, 92.4 77.68, 999.0 out-out out 13.1596 Saltbr-out 10.4376 HRD-in -66.1, -59.16 82.47, -6.26 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.47 APE8-dihe-in -82.95, 68.33 APE8-rot-na 32.13 APE67-dihe-in -69.29, -8.38 -57.66, -41.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1601 T790M,V948R None None XRAY 1.9 0.195 0.217 B 333.0 268.0 18 30 12 18 [[712, 970]] 1.0 7a2a Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 7G9

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name