Ligand: 7A7

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 5LXDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTIA P49759 150 482 484.0 7A7:605 Type1 Active DFGin 7.2921 14.242 BLAminus -134.7, 172.33 69.03, 94.12 -110.31, 22.0 290.95, 98.93 -72.82, -22.05 in-in in 8.6449 Saltbr-in 2.6167 HRD-in -68.46, -54.35 84.41, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.8883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 154.97 APE9-dihe-na 84.02, 157.2 APE8-dihe-in -78.01, 116.07 APE8-rot-in 301.91 APE67-dihe-in -65.16, -18.0 -14.75, -58.2 APE12-dist-in 13.4174 APE11-dist-in 11.0368 APE10-dist-in 7.4563 APE9-dist-in 3.0199 None None None XRAY 2.4 0.198 0.256 A 339.0 329.0 4 25 25 0 [[161, 477]] 1.0 6yti CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC DYRK2 DYRK2_HUMAN 5LXDA Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.0444 15.0379 BLAminus -123.98, 173.69 67.75, 85.87 -103.32, 20.02 290.69, 80.27 -60.79, -26.58 in-in in 8.9847 Saltbr-in 2.7177 HRD-in -78.02, -45.82 73.2, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.9329 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.87, 166.87 APE9-dihe-na 75.57, 144.69 APE8-dihe-in -63.57, 135.03 APE8-rot-out 186.77 APE67-dihe-in -56.98, -18.46 -55.94, -51.68 APE12-dist-in 13.2571 APE11-dist-in 12.1214 APE10-dist-in 7.6479 APE9-dist-in 3.3298 None PTR382 PTR382 XRAY 2.58 0.2 0.253 A 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxd CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 5LXDB Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.0169 15.0025 BLAminus -125.15, 174.13 66.86, 85.87 -102.41, 18.55 290.97, 80.01 -60.53, -24.71 in-in in 8.9909 Saltbr-in 2.7861 HRD-in -79.02, -46.62 74.88, 2.37 in-in-out SNCiio in-out ActLoopNT-in 2.8668 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.84, 168.16 APE9-dihe-na 73.17, 145.14 APE8-dihe-in -63.72, 133.94 APE8-rot-out 182.75 APE67-dihe-in -55.28, -20.15 -52.56, -53.24 APE12-dist-in 13.2821 APE11-dist-in 12.1273 APE10-dist-in 7.6646 APE9-dist-in 3.299 None PTR382 PTR382 XRAY 2.58 0.2 0.253 B 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxd CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: 7A7

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 5LXDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTIA P49759 150 482 484.0 7A7:605 Type1 Active DFGin 7.2921 14.242 BLAminus -134.7, 172.33 69.03, 94.12 -110.31, 22.0 290.95, 98.93 -72.82, -22.05 in-in in 8.6449 Saltbr-in 2.6167 HRD-in -68.46, -54.35 84.41, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.8883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 154.97 APE9-dihe-na 84.02, 157.2 APE8-dihe-in -78.01, 116.07 APE8-rot-in 301.91 APE67-dihe-in -65.16, -18.0 -14.75, -58.2 APE12-dist-in 13.4174 APE11-dist-in 11.0368 APE10-dist-in 7.4563 APE9-dist-in 3.0199 None None None XRAY 2.4 0.198 0.256 A 339.0 329.0 4 25 25 0 [[161, 477]] 1.0 6yti Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1.0 301.0 301.0 324 325 326 328 330 191 206 210 285 287 286 288.0 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC DYRK2 DYRK2_HUMAN 5LXDA Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.0444 15.0379 BLAminus -123.98, 173.69 67.75, 85.87 -103.32, 20.02 290.69, 80.27 -60.79, -26.58 in-in in 8.9847 Saltbr-in 2.7177 HRD-in -78.02, -45.82 73.2, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.9329 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.87, 166.87 APE9-dihe-na 75.57, 144.69 APE8-dihe-in -63.57, 135.03 APE8-rot-out 186.77 APE67-dihe-in -56.98, -18.46 -55.94, -51.68 APE12-dist-in 13.2571 APE11-dist-in 12.1214 APE10-dist-in 7.6479 APE9-dist-in 3.3298 None PTR382 PTR382 XRAY 2.58 0.2 0.253 A 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxd Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 5LXDB Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.0169 15.0025 BLAminus -125.15, 174.13 66.86, 85.87 -102.41, 18.55 290.97, 80.01 -60.53, -24.71 in-in in 8.9909 Saltbr-in 2.7861 HRD-in -79.02, -46.62 74.88, 2.37 in-in-out SNCiio in-out ActLoopNT-in 2.8668 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.84, 168.16 APE9-dihe-na 73.17, 145.14 APE8-dihe-in -63.72, 133.94 APE8-rot-out 182.75 APE67-dihe-in -55.28, -20.15 -52.56, -53.24 APE12-dist-in 13.2821 APE11-dist-in 12.1273 APE10-dist-in 7.6646 APE9-dist-in 3.299 None PTR382 PTR382 XRAY 2.58 0.2 0.253 B 408.0 386.0 0 25 25 0 [[222, 535]] 1.0 5lxd Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: 7A7

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name