Ligand: 7A7

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 5LXDA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTIA P49759 150 482 484.0 7A7:605 Type1 Active DFGin 7.292 14.242 BLAminus -134.7, 172.33 69.03, 94.12 -110.31, 22.0 290.95, 98.93 -72.82, -22.05 in-in in 8.645 Saltbr-in 2.617 HRD-in -68.46, -54.35 84.41, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 154.97 APE9-dihe-na 84.02, 157.2 APE8-dihe-in -78.01, 116.07 APE8-rot-in 301.91 APE67-dihe-in -65.16, -18.0 -14.75, -58.2 APE12-dist-in 13.417 APE11-dist-in 11.037 APE10-dist-in 7.456 APE9-dist-in 3.02 None None None XRAY 2.4 0.198 0.256 A 339 329 4 0 0 0 [[161, 477]] 1.0 6yti CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC DYRK2 DYRK2_HUMAN 5LXDA Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.044 15.038 BLAminus -123.98, 173.69 67.75, 85.87 -103.32, 20.02 290.69, 80.27 -60.79, -26.58 in-in in 8.985 Saltbr-in 2.718 HRD-in -78.02, -45.82 73.2, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.87, 166.87 APE9-dihe-na 75.57, 144.69 APE8-dihe-in -63.57, 135.03 APE8-rot-out 186.77 APE67-dihe-in -56.98, -18.46 -55.94, -51.68 APE12-dist-in 13.257 APE11-dist-in 12.121 APE10-dist-in 7.648 APE9-dist-in 3.33 None PTR382 PTR382 XRAY 2.58 0.2 0.253 A 408 386 0 0 0 0 [[222, 535]] 1.0 5lxd CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 5LXDB Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.017 15.002 BLAminus -125.15, 174.13 66.86, 85.87 -102.41, 18.55 290.97, 80.01 -60.53, -24.71 in-in in 8.991 Saltbr-in 2.786 HRD-in -79.02, -46.62 74.88, 2.37 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.84, 168.16 APE9-dihe-na 73.17, 145.14 APE8-dihe-in -63.72, 133.94 APE8-rot-out 182.75 APE67-dihe-in -55.28, -20.15 -52.56, -53.24 APE12-dist-in 13.282 APE11-dist-in 12.127 APE10-dist-in 7.665 APE9-dist-in 3.299 None PTR382 PTR382 XRAY 2.58 0.2 0.253 B 408 386 0 0 0 0 [[222, 535]] 1.0 5lxd CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: 7A7

Total number of chains: 3
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 5LXDA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CLK1 CLK1_HUMAN 6YTIA P49759 150 482 484.0 7A7:605 Type1 Active DFGin 7.292 14.242 BLAminus -134.7, 172.33 69.03, 94.12 -110.31, 22.0 290.95, 98.93 -72.82, -22.05 in-in in 8.645 Saltbr-in 2.617 HRD-in -68.46, -54.35 84.41, -17.31 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.78, 154.97 APE9-dihe-na 84.02, 157.2 APE8-dihe-in -78.01, 116.07 APE8-rot-in 301.91 APE67-dihe-in -65.16, -18.0 -14.75, -58.2 APE12-dist-in 13.417 APE11-dist-in 11.037 APE10-dist-in 7.456 APE9-dist-in 3.02 None None None XRAY 2.4 0.198 0.256 A 339 329 4 0 0 0 [[161, 477]] 1.0 6yti Homo sapiens CMGC_CLK1_HUMAN CMGC 2.5e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC DYRK2 DYRK2_HUMAN 5LXDA Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.044 15.038 BLAminus -123.98, 173.69 67.75, 85.87 -103.32, 20.02 290.69, 80.27 -60.79, -26.58 in-in in 8.985 Saltbr-in 2.718 HRD-in -78.02, -45.82 73.2, 0.43 in-in-out SNCiio in-out ActLoopNT-in 2.933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.87, 166.87 APE9-dihe-na 75.57, 144.69 APE8-dihe-in -63.57, 135.03 APE8-rot-out 186.77 APE67-dihe-in -56.98, -18.46 -55.94, -51.68 APE12-dist-in 13.257 APE11-dist-in 12.121 APE10-dist-in 7.648 APE9-dist-in 3.33 None PTR382 PTR382 XRAY 2.58 0.2 0.253 A 408 386 0 0 0 0 [[222, 535]] 1.0 5lxd Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC DYRK2 DYRK2_HUMAN 5LXDB Q92630 153 538 601.0 7A7:60501 Type1 Inactive DFGin 7.017 15.002 BLAminus -125.15, 174.13 66.86, 85.87 -102.41, 18.55 290.97, 80.01 -60.53, -24.71 in-in in 8.991 Saltbr-in 2.786 HRD-in -79.02, -46.62 74.88, 2.37 in-in-out SNCiio in-out ActLoopNT-in 2.867 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.84, 168.16 APE9-dihe-na 73.17, 145.14 APE8-dihe-in -63.72, 133.94 APE8-rot-out 182.75 APE67-dihe-in -55.28, -20.15 -52.56, -53.24 APE12-dist-in 13.282 APE11-dist-in 12.127 APE10-dist-in 7.665 APE9-dist-in 3.299 None PTR382 PTR382 XRAY 2.58 0.2 0.253 B 408 386 0 0 0 0 [[222, 535]] 1.0 5lxd Homo sapiens CMGC_DYRK2_HUMAN CMGC 1.2e-98 336.0 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand: 7A7

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name