Ligand: 6R0

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5K7GC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 5K7GA Q9NWZ3 164 458 460.0 6R0:503 Type1 Active DFGin 6.9273 14.5789 BLAminus -130.44, 172.6 63.09, 86.67 -104.49, 18.83 308.78, 101.81 -65.52, -32.04 in-in in 8.8776 Saltbr-in 3.3007 HRD-in -67.24, -50.39 78.51, -10.38 in-in-in SNCiii in-in ActLoopNT-in 2.8499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.81, 145.66 APE9-dihe-na 138.88, -174.27 APE8-dihe-in -106.05, 110.69 APE8-rot-in 312.32 APE67-dihe-in -63.78, -20.0 -39.72, -49.62 APE12-dist-in 10.0827 APE11-dist-in 11.8705 APE10-dist-in 6.4292 APE9-dist-in 4.12 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 A 301.0 279.0 16 30 23 7 [[183, 456]] 1.0 5k7g TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7GB Q9NWZ3 165 458 460.0 6R0:503 Type1 None DFGin 6.9828 14.5764 BLAminus -125.44, 169.29 65.46, 85.11 -103.67, 20.54 309.11, 102.13 -65.88, -35.43 in-in in 8.8953 Saltbr-in 3.1333 HRD-in -66.71, -50.75 79.24, -11.2 in-in-none SNCiin in-none ActLoopNT-in 2.8554 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 145.13 APE9-dihe-na 139.01, -174.96 APE8-dihe-in -106.13, 110.24 APE8-rot-in 312.27 APE67-dihe-in -64.1, -19.47 -39.24, -50.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.428 APE9-dist-in 4.132 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 B 301.0 275.0 19 30 16 14 [[183, 456]] 1.0 5k7g TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7GC Q9NWZ3 164 458 460.0 6R0:501 Type1 Active DFGin 6.9575 14.4653 BLAminus -132.74, 161.94 65.76, 88.06 -104.31, 18.89 309.03, 102.17 -65.27, -31.9 in-in in 8.8581 Saltbr-in 2.8923 HRD-in -66.94, -50.37 77.56, -9.09 in-in-in SNCiii in-in ActLoopNT-in 2.8541 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 146.49 APE9-dihe-na 138.07, -172.84 APE8-dihe-in -106.43, 110.54 APE8-rot-in 312.48 APE67-dihe-in -63.68, -20.75 -40.38, -49.26 APE12-dist-in 10.1719 APE11-dist-in 11.746 APE10-dist-in 6.3479 APE9-dist-in 4.1262 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 C 301.0 285.0 10 30 23 7 [[183, 456]] 1.0 5k7g TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7GD Q9NWZ3 164 458 460.0 6R0:502 Type1 Active DFGin 6.9139 14.4521 BLAminus -130.04, 170.31 63.99, 86.8 -104.75, 18.86 309.06, 102.0 -64.76, -32.56 in-in in 8.818 Saltbr-in 3.1217 HRD-in -66.7, -50.93 78.39, -9.43 in-in-in SNCiii in-in ActLoopNT-in 2.8521 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.67, 145.96 APE9-dihe-na 138.88, -173.03 APE8-dihe-in -106.21, 110.06 APE8-rot-in 312.19 APE67-dihe-in -64.22, -19.64 -40.02, -49.24 APE12-dist-in 10.0286 APE11-dist-in 11.7906 APE10-dist-in 6.3793 APE9-dist-in 4.1312 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 D 301.0 285.0 10 30 23 7 [[183, 456]] 1.0 5k7g TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: 6R0

Total number of chains: 4
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 5K7GC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 5K7GA Q9NWZ3 164 458 460.0 6R0:503 Type1 Active DFGin 6.9273 14.5789 BLAminus -130.44, 172.6 63.09, 86.67 -104.49, 18.83 308.78, 101.81 -65.52, -32.04 in-in in 8.8776 Saltbr-in 3.3007 HRD-in -67.24, -50.39 78.51, -10.38 in-in-in SNCiii in-in ActLoopNT-in 2.8499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.81, 145.66 APE9-dihe-na 138.88, -174.27 APE8-dihe-in -106.05, 110.69 APE8-rot-in 312.32 APE67-dihe-in -63.78, -20.0 -39.72, -49.62 APE12-dist-in 10.0827 APE11-dist-in 11.8705 APE10-dist-in 6.4292 APE9-dist-in 4.12 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 A 301.0 279.0 16 30 23 7 [[183, 456]] 1.0 5k7g Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7GB Q9NWZ3 165 458 460.0 6R0:503 Type1 None DFGin 6.9828 14.5764 BLAminus -125.44, 169.29 65.46, 85.11 -103.67, 20.54 309.11, 102.13 -65.88, -35.43 in-in in 8.8953 Saltbr-in 3.1333 HRD-in -66.71, -50.75 79.24, -11.2 in-in-none SNCiin in-none ActLoopNT-in 2.8554 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 145.13 APE9-dihe-na 139.01, -174.96 APE8-dihe-in -106.13, 110.24 APE8-rot-in 312.27 APE67-dihe-in -64.1, -19.47 -39.24, -50.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.428 APE9-dist-in 4.132 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 B 301.0 275.0 19 30 16 14 [[183, 456]] 1.0 5k7g Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7GC Q9NWZ3 164 458 460.0 6R0:501 Type1 Active DFGin 6.9575 14.4653 BLAminus -132.74, 161.94 65.76, 88.06 -104.31, 18.89 309.03, 102.17 -65.27, -31.9 in-in in 8.8581 Saltbr-in 2.8923 HRD-in -66.94, -50.37 77.56, -9.09 in-in-in SNCiii in-in ActLoopNT-in 2.8541 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 146.49 APE9-dihe-na 138.07, -172.84 APE8-dihe-in -106.43, 110.54 APE8-rot-in 312.48 APE67-dihe-in -63.68, -20.75 -40.38, -49.26 APE12-dist-in 10.1719 APE11-dist-in 11.746 APE10-dist-in 6.3479 APE9-dist-in 4.1262 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 C 301.0 285.0 10 30 23 7 [[183, 456]] 1.0 5k7g Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7GD Q9NWZ3 164 458 460.0 6R0:502 Type1 Active DFGin 6.9139 14.4521 BLAminus -130.04, 170.31 63.99, 86.8 -104.75, 18.86 309.06, 102.0 -64.76, -32.56 in-in in 8.818 Saltbr-in 3.1217 HRD-in -66.7, -50.93 78.39, -9.43 in-in-in SNCiii in-in ActLoopNT-in 2.8521 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.67, 145.96 APE9-dihe-na 138.88, -173.03 APE8-dihe-in -106.21, 110.06 APE8-rot-in 312.19 APE67-dihe-in -64.22, -19.64 -40.02, -49.24 APE12-dist-in 10.0286 APE11-dist-in 11.7906 APE10-dist-in 6.3793 APE9-dist-in 4.1312 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 D 301.0 285.0 10 30 23 7 [[183, 456]] 1.0 5k7g Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: 6R0

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name