Ligand: 6QZ

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 5K7IA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 5K7IA Q9NWZ3 164 458 460.0 6QZ:501 Type1 Active DFGin 6.8482 14.706 BLAminus -122.1, 174.72 61.52, 86.0 -106.72, 22.05 309.28, 97.65 -66.92, -32.98 in-in in 8.6948 Saltbr-in 3.1305 HRD-in -68.39, -48.54 78.53, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.8118 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.35, 153.63 APE9-dihe-na 131.32, 179.82 APE8-dihe-in -93.7, 123.26 APE8-rot-in 312.64 APE67-dihe-in -64.14, -19.99 -53.75, -46.67 APE12-dist-in 10.1861 APE11-dist-in 11.8474 APE10-dist-in 6.4429 APE9-dist-in 4.0857 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.221 0.257 A 301.0 274.0 21 30 23 7 [[183, 456]] 1.0 5k7i TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7IB Q9NWZ3 164 458 460.0 6QZ:502 Type1 Active DFGin 6.8645 14.5179 BLAminus -124.19, 174.89 61.8, 86.03 -106.67, 22.39 309.0, 97.79 -67.01, -31.74 in-in in 8.7394 Saltbr-in 2.7998 HRD-in -68.08, -49.13 78.29, -7.61 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.12, 153.82 APE9-dihe-na 132.9, -179.87 APE8-dihe-in -93.91, 123.35 APE8-rot-in 313.14 APE67-dihe-in -65.54, -19.28 -54.52, -46.07 APE12-dist-in 10.1598 APE11-dist-in 11.6579 APE10-dist-in 6.3434 APE9-dist-in 4.1334 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.221 0.257 B 301.0 273.0 22 30 23 7 [[183, 456]] 1.0 5k7i TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: 6QZ

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 5K7IA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL IRAK4 IRAK4_HUMAN 5K7IA Q9NWZ3 164 458 460.0 6QZ:501 Type1 Active DFGin 6.8482 14.706 BLAminus -122.1, 174.72 61.52, 86.0 -106.72, 22.05 309.28, 97.65 -66.92, -32.98 in-in in 8.6948 Saltbr-in 3.1305 HRD-in -68.39, -48.54 78.53, -8.67 in-in-in SNCiii in-in ActLoopNT-in 2.8118 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.35, 153.63 APE9-dihe-na 131.32, 179.82 APE8-dihe-in -93.7, 123.26 APE8-rot-in 312.64 APE67-dihe-in -64.14, -19.99 -53.75, -46.67 APE12-dist-in 10.1861 APE11-dist-in 11.8474 APE10-dist-in 6.4429 APE9-dist-in 4.0857 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.221 0.257 A 301.0 274.0 21 30 23 7 [[183, 456]] 1.0 5k7i Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7IB Q9NWZ3 164 458 460.0 6QZ:502 Type1 Active DFGin 6.8645 14.5179 BLAminus -124.19, 174.89 61.8, 86.03 -106.67, 22.39 309.0, 97.79 -67.01, -31.74 in-in in 8.7394 Saltbr-in 2.7998 HRD-in -68.08, -49.13 78.29, -7.61 in-in-in SNCiii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.12, 153.82 APE9-dihe-na 132.9, -179.87 APE8-dihe-in -93.91, 123.35 APE8-rot-in 313.14 APE67-dihe-in -65.54, -19.28 -54.52, -46.07 APE12-dist-in 10.1598 APE11-dist-in 11.6579 APE10-dist-in 6.3434 APE9-dist-in 4.1334 None TPO345,SEP346 TPO345,SEP346 XRAY 2.31 0.221 0.257 B 301.0 273.0 22 30 23 7 [[183, 456]] 1.0 5k7i Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4

Ligand: 6QZ

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name